Adewale OO, Samuel ES, Manubolu M,
Pathakoti K. 2019. Curcumin protects
sodium nitrite-induced hepatotoxicity in
Wistar rats. Toxicol Rep, 21: 1006-1011.
Akhzari M, Shafiee SM, Rashno S, Akmali M.
2019. Berberine attenuated oxidative stress
induced by sodium nitrite in rat liver.
Jundishapur J Nat Pharm Prod, 14: e68532.
Alavinezhad A, Hedayati M, Boskabady M.
2017. The effect of Zataria multiflora and
carvacrol on wheezing, FEV1 and plasma
levels of nitrite in asthmatic patients.
Avicenna J Phytomed, 7: 531-541.
Alexander J, Benford D, Cockburn A, Cravedi
JP, Dogliotti E, Domenico AD, FérnandezCruz ML, Fürst P, Fink-Gremmels J, Galli
CL, Grandjean P, Gzyl J, Heinemeyer G,
Johansson N, Mutti A, Schlatter J,
Leeuwen R, Van Peteghem C, Verger P.
2009. Scientific opinion nitrite as
undesirable substances in animal feed.
EFSAJ, 1017: 1-47.
Amin F, Roohbakhsh A, Memarzia A,
Kazerani H, Boskabady M. 2020. Paraquatinduced systemic inflammation and
increased oxidative markers in rats
improved by Zataria multiflora extract and
carvacrol. Avicenna J Phytomed, 10: 513-
522.
Blumenthal M, Editor. 2000. Herbal medicine.
First ed. USA: Integrative Medicine
Communications, 519.
Chatterjee S. 2016. Oxidative stress,
inflammation, and disease. In: Dziubla, T
Butterfield DA, editors. Oxidative stress
and biomaterials. Academic Press,
Cambridge; 35-58.
Chattopadhyay N, Maurya R. 2015. Herbal
medicine, reference module in biomedical
sciences, Elsevier.
Denicola A, Radi R. 2005. Peroxynitrite and
Ahmadi et al.
AJP, Vol. 12, No. 3, May-Jun 2022 222
drug-dependent toxicity. Toxicol, 208: 273-
288.
Eyiler E, Oztan A. 2011. Production of
frankfurters with tomato powder as a
natural additive. Food Sci Technol, 44:
307-311.
Fadda LM, Attia HA, Al-Rasheed NM, Ali
HM, Al-Rasheed NM. 2018. Roles of some
antioxidants in modulation of cardiac
myopathy induced by sodium nitrite via
down-regulation of mRNA expression of
NF-κB, Bax, and flt-1 and suppressing
DNA damage. Saudi Pharm J, 26: 217-223.
Golkar P, Mosavat N, Jalali SAH. 2020.
Essential oils, chemical constituents,
antioxidant, antibacterial and in vitro
cytotoxic activity of different Thymus
species and Zataria multiflora collected
from Iran. S Afr J Bot, 130: 250-258.
Hajihashemi S, Jafarian T, Ahmadi M,
Rahbari A, Hosseini N. 2015. The effects
of Zataria Multiflora hydroalcoholic
extract on gentamicin induced
nephrotoxicity in rats. J Arak Uni Med Sci,
18: 35-48.
Karwowska M, Kononiuk A. 2020.
Nitrates/nitrites in food-risk for nitrosative
stress and benefits. Antioxidants (Basel,
Switzerland), 9: 241.
Kavoosi G, Mohammadi Purfard A, Aram F.
2012. Radical scavenging properties of
essential oils from Zataria multiflora and
Ferula assafoetida. Asian Pac J Trop
Biomed, 2: S1351-S1356.
Khazdair MR, Alavinezhad A, Boskabady
MH. 2018. Carvacrol ameliorates
haematological parameters,
oxidant/antioxidant biomarkers and
pulmonary function tests in patients with
sulphur mustard-induced lung disorders: A
randomized double-blind clinical trial. J
Clin Pharm Ther, 43: 664-674.
Khazdair MR, Boskabady MH. 2019. A
double-blind, randomized, placebocontrolled clinical trial on the effect of
carvacrol on serum cytokine levels and
pulmonary function tests in sulfur mustard
induced lung injury. Cytokine, 113: 311-
318.
Khazdair MR, Ghorani V, Alavinezhad A,
Boskabady MH. 2018. Pharmacological
effects of Zataria multiflora Boiss L. and
its constituents focus on their antiinflammatory, antioxidant, and
immunomodulatory effects. Fundam Clin
Pharmacol, 32: 26-50.
Khazdair MR, Rajabi O, Balali-Mood M,
Beheshti F, Boskabady MH. 2018. The
effect of Zataria multiflora on pulmonary
function tests, hematological and
oxidant/antioxidant parameters in sulfur
mustard exposed veterans, a randomized
doubled-blind clinical trial. Environ
Toxicol Pharmacol, 58: 180-188.
Khazdair MR, Rezaeetalab F, Rafatpanah H,
Boskabady MH. 2020. The effect of
Zataria multiflora on inflammatory
cytokine and respiratory symptoms in
veterans exposed to sulfur mustard.
Environ Sci Pollut Res Int, 27: 22451-
22460.
Kiani A, Yousefsani BS, Doroudian P, Seydi
E, Pourahmad J. 2017. The mechanism of
hepatotoxic effects of sodium nitrite on
isolated rat hepatocytes. Toxicol Environ
Health Sci, 9: 244-250.
Knowles RG, Merrett M, Salter M, Moncada
S. 1990. Differential induction of brain,
lung and liver nitric oxide synthase by
endotoxin in the rat. Biochem J, 270: 833-
836.
Kroupova H, Machova J, Svobodova Z. 2005.
Nitrite influence on fish: a review. Vet Med
Czech, 50: 461-471.
Li J, Li W, Su J, Liu W, Altura BT, Altura
BM. 2004. Peroxynitrite induces apoptosis
in rat aortic smooth muscle cells: possible
relation to vascular diseases. Exp Biol Med
(Maywood), 229: 264-269.
Li D, Liu S. 2019. Water quality monitoring
and management: basis, technology and
case studies. Chapter 13-Detection of
industrial water quality, 1st Edition,
Academic Press, 329-349.
Lundberg JO, Weitzber E, Gladwin MT. 2008.
The nitrate-nitrite-nitric oxide pathway in
physiology and therapeutics. Nat Rev Drug
Discov, 7: 156-167.
Mahmoodi M, Koohpeyma F, Saki F,
Maleksabet A, Zare M. 2019. The
protective effect of Zataria multiflora
Boiss. hydroalcoholic extract on TNF-α
production, oxidative stress, and insulin
level in streptozotocin-induced diabetic
rats. Avicenna J Phytomed, 9: 72-83.
Mahmoudvand H, Tavakoli Kareshk A,
Moradi MN, Mirbadi SR, Niazi M,
Khatami M. 2020. Efficacy and safety of
Zataria multiflora Boiss essential oil
against acute toxoplasmosis in mice. Iran J
Effect of Zataria multiflora Boiss against sodium nitrite-induced hepatotoxicity
AJP, Vol. 12, No. 3, May-Jun 2022 223
Parasitol, 15: 22-30.
Marouf BH, Zalzala MH, Al-Khalifa II, Aziz
TA, Hussain SA. 2011. Free radical
scavenging activity of silibinin in nitriteinduced hemoglobin oxidation and
membrane fragility models. Saudi Pharm J,
3: 177-183.
Mehdipour Z, Afsharmanesh M, Sami M.
2013. Effects of supplemental thyme
extract (Thymus vulgaris L.) on growth
performance, intestinal microbial
populations, and meat quality in Japanese
quails. Comp Clin Pathol, 23: 1503-1508.
Mohebbati R, Paseban M, Soukhtanloo M,
Jalili-Nik M, Shafei MN, Yazdi AJ, Rad
AK. 2018. Effects of standardized Zataria
multiflora extract and its major ingredient,
Carvacrol, on Adriamycin-induced
hepatotoxicity in rat. Biomed J, 41: 340-
347.
Mostafa Mohamed Ali E, Adnan Zeyadi M.
2020. Impact of caffeic acid phenylester on
nitric oxide synthase and arginase in rats
intoxicated with nitrites. J King Saud Univ
Sci, 32: 2454-2461.
Müller C, Musolff A, Strachauer U, Brauns M,
Tarasova L, Merz R, Knöller K. 2018.
Tomography of anthropogenic nitrate
contribution along a mesoscale river. Sci
Total Environ, 615: 773-783.
Ohkawa H, Ohishi N, Yagi K. 1979. Assay for
lipid peroxides in animal tissues by
thiobarbituric acid reaction. Anal Biochem,
95: 351-358.
Padmavathi M. 2013. Drug delivery system in
nano greens. Int J Herbal Med, 1: 56-60.
Pek NMQ, Liu KJ, Nichane M, Ang LT. 2021.
Controversies surrounding the origin of
hepatocytes in adult livers and the in vitro
generation or propagation of hepatocytes.
Cell Mol Gastroenterol Hepatol, 11: 273-
290.
Rana P, Soni G. 2008. Antioxidant potential of
thyme extract: alleviation of N-nitrosodie
thylamine - induced oxidative stress. Hum
Experiment Toxicol, 27: 215-221.
Sakhaee E, Ladan E, Azari O, Sistani F. 2011.
Evaluation of the beneficial effects of
zataria multiflora Boiss in halothaneinduced hepatotoxicity in rats, Adv Clin
Exp Med, 20: 23-29.
Sharififar F, Derakhshanfar A, DehghanNudeh G, Abbasi N, Abbasi R, Rezaei
Gharaei R, Koohpayeh A, Daneshpajouh,
M. 2011. In vivo antioxidant activity of
Zataria multiflora Boiss essential oil. Pak J
Pharm Sci, 24: 221-225.
Sheibani V, Mandegary A, Vazifekhahan E,
Kasbzade Z, Asadi A, Sharififar F. 2019.
Zataria multiflora Boiss extract improves
spatial memory and learning capacity in
scopolamine-induced amnesic rats.
Avicenna J Phytomed, 9: 587-596.
Yap CYF, Choon AW. 2010. Liver function
tests (LFts). Proceedings of Singapoor
Healthcare, 19: 80-82.
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