TY - JOUR ID - 13465 TI - In vitro antibacterial activity of curcumin-meropenem combination against extensively drug-resistant (XDR) bacteria isolated from burn wound infections JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Yasbolaghy sharahi, javad AU - Ahovan, zahra AU - Taghizadeh Maleki, Donya AU - Riahi Rad, Zahra AU - Riahi Rad, Zohreh AU - Goudarzi, Mehdi AU - Shariati, Aref AU - Bostanghadiri, Narjess AU - Abbasi, Elham AU - Hashemi, Ali AD - Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. AD - Depratment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Y1 - 2020 PY - 2020 VL - 10 IS - 1 SP - 3 EP - 10 KW - Curcumin KW - Meropenem KW - Extensively drug-resistant (XDR) KW - Antibacterial KW - Wound KW - Infections DO - 10.22038/ajp.2019.13465 N2 - Objective: Burn wound infection is a severe complication of thermal injury. Patients with severe burn injuries need urgent care to diminish complications after severe burns. Wound infections are commonly considered one of the most serious burn complications, particularly those that are caused by extensively drug-resistant (XDR) bacteria with few therapeutic choices. The objective of this study was to determine in vitro activity of meropenem and curcumin, alone and in combination, against antibiotic-susceptible Gram-positive, and antibiotic-resistant and antibiotic susceptible gram-negative bacteria isolated from burn wound infections. Materials and Methods: The antimicrobial activity of meropenem and curcumin was investigated alone and in combination, against antibiotic-susceptible and antibiotic-resistant bacterial (XDR) strains isolated from burn patients. In addition, the cytotoxic effect of curcumin on human’s epithelial cell lines, was determined. Results: In this study, minimum inhibitory concentrations of meropenem decreased considerably in the presence of curcumin (2- to 16-fold reductions), with synergy observed. Curcumin exerted no cytotoxic effect at concentrations 256-512 µg/ml on human epithelial cell lines. Conclusion: We suggest that curcumin-antibiotic combinations may provide an alternative approach for treating infections with multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacteria. UR - https://ajp.mums.ac.ir/article_13465.html L1 - https://ajp.mums.ac.ir/article_13465_a625c074febc1f42afd489928be717e5.pdf ER -