Abdul H, Ataur R, Abdullah Al M Sohag, J,
Raju D, Mahmudul H. 2021. Black
Cumin (Nigella sativa L.): A
Comprehensive Review on
Phytochemistry, Health Benefits,
Molecular Pharmacology, and Safety.
Nutrients, 13: 1784-1794.
Abouzaripour M, Hosaini Bae M, Rezaie
MJ, Nikkho B, Allahveisi A, Roshani D,
Khalesro SH, Daneshi E. 2019. Protective
effect of Nigella sativa on sperm
parameters in mice exposed to titanium
dioxide during embryonic development.
Sci J Kurd Univ Med Sci, 100: 66-73.
Ahmad A, Husain A, Mujeeb M, Khan SA,
Najmi AK, Siddique NA, Damanhouri
ZA, Anwar F. 2013. A review on
therapeutic potential of Nigella sativa: A
miracle herb. Asian Pac J Trop Biomed,
3: 337-352.
Akram Khan M, Afzal M. 2016. Chemical
Nigella sativa on the testicular function
AJP, Vol. 13, No. 5, Sep-Oct 2023 549
composition of Nigella sativa Linn: Part
2 Recent advances. Inflammopharmacol,
24: 67-79.
Alkilany AM, Murphy CJ. 2010. Toxicity and
cellular uptake of gold nanoparticles.
Nanopart Res, 12: 2313-2333.
Cho Ping N, Hashim NH, Hasan Adli DS.
2014. Effects of Nigella sativa Habbatus
sauda oil and nicotine chronic treatments
on sperm parameters and testis
histological features of rats. Evid Based
Complement Alternat Med, 2014:
218293.
De França LR, Ghosh S, Ye S J, Russell LD.
1993. Surface and surface-to-volume
relationships of the Sertoli cell during the
cycle of the seminiferous epithelium in
the rat. Biol Rerprod, 49: 1215-1228.
Esmaili-Nejad MR, Babaei H, Kheirandish
R. 2015. The effects of long-term leptin
administration on morphometrical
changes of mice testicular tissue. Iran J
Basic Med Sci, 18: 1176-1182.
Gurr JR, Wang ASS, Chen CH, Jan KY.
2005. Ultrafine titanium dioxide particles
in the absence of photoactivation can
induce oxidative damage to human
bronchial epithelial cells. Toxicology,
213: 66-73.
Hajshafiha M, Ghareaghaji R, Salemi S,
Sadegh-Asadi N, Sadeghi-Bazargani H.
2013. Association of body mass index
with some fertility markers among male
partners of infertile couples. Int J Gen
Med, 6: 447-451.
Han JW, Jeong JK , Gurunathan S, Choi YJ,
Das J, Kwon DN, Cho SG, Park C, Seo
HG, Park JK, Kim JH. 2016. Male- and
female-derived somatic and germ cellspecific toxicity of silver nanoparticles in
mouse. Nanotoxicology, 10: 361-373.
Hannan MA, Rahman MA, Sohag AM, Uddin
MJ, Dash R, Sikder MH, Rahman MS,
Timalsina B, Munni YA, Sarker PP,
Alam M, Mohibbullah M, Haque MN,
Jahan I, Hossain MT, Afrin T, Rahman
MM, Tahjib-Ul-Arif M, Mitra S,
Oktaviani DF, Khan MK, Choi HJ, Moon
IS, Ki B. 2021. Black cumin (Nigella
sativa L.): A comprehensive review on
phytochemistry, health benefits,
molecular pharmacology, and safety.
Nutrients, 13: 17-24.
Hasan S. 2015. A Review on nanoparticles:
Their synthesis and types. Res J Recent
Sci, 4: 9-11.
Hooley RP, Paterson M, Brown P, Kerr K,
Saunders PT. 2009. Intra-testicular
injection of adenoviral constructs results
in Sertoli cell-specific gene expression
and disruption of the seminiferous
epithelium. Reproduction, 137: 361-370.
Jiang XH, Bukhari I, Zheng W, Yin S, Wang
Z, Cooke H, Shi QH. 2014. Blood-testis
barrier and spermatogenesis: lessons
from genetically-modified mice. Asian J
Androl, 16: 572-580.
Karunamoorthi K, Jegajeevanram K,
Vijayalakshmi J, Mengistie E. 2013.
Traditional medicinal plants:A source of
phytotherapeutic modality in resourceconstrained health care settings. ECAM,
18: 67-74.
Koeneman BA, Zhang Y, Westerhoff P, Chen
Y, Crittenden JC, Capco DG. 2010.
Toxicity and cellular responses of
intestinal cells exposed to titanium
dioxide. Cell Biol Toxicol, 26: 225-238.
Kopera IA, Bilinska B, Cheng CY, Mruk DD.
2010. Sertoli-germ cell junctions in the
testis: a review of recent data. Philos
Trans R Soc Lond B Biol Sci, 365: 1593-
1605.
Krzastek SC, Farhi J, Gray M, Smith RP.
2020. Impact of environmental toxin
exposure on male fertility potential.
Transl Androl Urol, 9: 2797-2813.
Lee J, Mahendra S, Alvarez PJ. 2010.
Nanomaterials in the construction
industry: a review of their applications
and environmental health and safety
considerations. ACS Nano, 4: 3580-3590.
McCarthy D, Malhotra M, O'Mahony A,
Cryan J, O'Driscoll C. 2015.
Nanoparticles and the blood-brain
barrier: Advancing from in-vitro models
towards therapeutic significance. Pharm
Res, 32: 1161-1185.
Miri S, Abouzarypor M, Rezaie MJ, Fathi F,
Nikkho B, Roshani D, Khalesro Sh,
Daneshi E. 2020. The protective effect of
Nigella sativa on sperm parameter in
mice treated with dexamethasone. SJKU,
25: 99-105.
Najahi-Missaoui W, Arnold RD, Cummings
BS. 2021. Safe nanoparticles: Are we
there yet? Int J Mol Sci, 22: 385.
Oatley JM, Tibary A, de Avila DM, Wheaton
JE, McLean DJ, Reeves JJ. 2005.
Changes in spermatogenesis and
Abouzaripour et al.
AJP, Vol. 13, No. 5, Sep-Oct 2023 550
endocrine function in the ram testis due
to irradiation and active immunization
against luteinizing hormone-releasing
hormone. J Anim Sci, 83: 604-612.
Orazizadeh M, Khorsandi L, Absalan F,
Hashemitabar M, Daneshi E. 2014.
Effect of beta-carotene on titanium oxide
nanoparticles-induced testicular toxicity
in mice. J Assist Reprod Genet, 31: 561-
568.
Parhizkar S, Latiff LA, Parsa A. 2016. Effect
of Nigella sativa on reproductive system
in experimental menopause rat model.
Avicenna J Phytomed, 6: 95-103.
Rachid M, Ibrahim Yousef M, Maranghi F,
Mantovani A. 2014. Protective role of
Nigella sativa oil against reproductive
toxicity, hormonal alterations, and
oxidative damage induced by
chlorpyrifos in male rats. Toxicol Ind
Health, 32: 456-462.
Soleimani MM, Shariatzadeh S, Azadpour M.
2015. Protective effect of Nigella sativa
oil on the Bisphenol A induced -testicular
toxicity in adult mice NMRI. Cell Tissue
Res, 6: 87-96.
Talebi AR, Khorsandi L, Moridian M. 2013.
The effect of zinc oxide nanoparticles on
mouse spermatogenesis. J Assist Reprod
Genet, 30: 1203-1209.
Thakur M, Gupta H, Singh D, Mohanty IR,
Maheswari U, Vanage G, Joshi DS.
2014. Histopathological and ultra
structural effects of nanoparticles on rat
testis following 90 days (Chronic study)
of repeated oral administration. J
Nanobiotechnology, 12: 42.
Tongnuanchan P, Benjakul S. 2014. Essential
oils: Extraction, bioactivities, and their
uses for food preservation. J Food Sci,
79: 1231-1249.
Vasyukova I, Gusev A, Tkachev A. 2015.
Reproductive toxicity of carbon
nanomaterials: a review. IOP Conf Ser:
Mater Sci Eng, 98: 123-132.
Yamagishi N, Ito Y, Ramdhan DH, Nakajima
T. 2011. Effects of nanoparticle-rich-diesel
exhaust on steroidogenesis in rats and the
mechanism underlying such effects. Nihon
Eiseigaku Zasshi, 66: 634-637.
Yin J, Sun K, Chen B. 2015. Time-dependent
toxic effects of N-ethyl-N-nitrosourea on
the testes of male C57BL/6J mice: a
histological and ultrastructural study. Int
J Clin Exp Pathol, 8: 1830-1843.
)