Adeneye AA, Adeyemi OO, Agbaje EO. 2010.
Anti-obesity and antihyperlipidemic effect
of hunteriaumbellata seed extract in
experimental hyperlipidemia. J
Ethnopharmacol, 130: 307-314.
Afiq AMJ, Rahman RA, Man YBC, ALKahtani HA, Mansor TST. 2013. Date
seed and date seed oil. Int Food Res J, 20:
2035-2043.
Ahmed J, Al‐Jasass FM, Siddiq M. 2014. Date
fruit composition and
nutrition. Dates: Postharvest Science, p,
261-283. Processing Technology and
Health Benefits.
Alamgir MA, Khan MA, Khan M, Alamgir I.
Ajwa dates and hyperlipidemia
AJP, Vol. 13, No. 2, Mar-Apr 2023 151
2022. Facts revealed; Total/high density
lipoprotein cholesterol values and their
ratios among macro-vascular
complications of diabetes. Pak Heart J, 55:
157-161.
Al-Farsi M, Alasalvar C, Morris A, Baron M,
Shahidi F. 2005. Comparison of
antioxidant activity, anthocyanins,
carotenoids and phenolics of three native
fresh and sun-dried date (Phoenix
dactylifera L.) varieties grown in Oman. J
Agric Food Chem, 53: 7592-7599.
Al-Farsi MA, Lee CY. 2008. Nutritional and
functional properties of dates: A review.
Crit Rev Food Sci Nutr, 48: 877-887.
Ali A, Abdu S. 2011. Antioxidant protection
against pathological mycotoxins
alterations on proximal tubules in rat
kidney. Funct Foods Health Dis, 1: 118-
134.
Al-Turki S, Shahba MA, Stushnoff C. 2010.
Diversity of antioxidant
properties and phenolic content of date
palm (Phoenix dactylifera L.) fruits as
affected by cultivar and location. J Food
Agric Environ, 8: 253-260.
Aludhaib R. 2015. Solvent extraction of
antioxidants, phenols and flavonoids from
Saudi Arabia dates. Dalhousie University
Halifax, Nova Scotia.
Amany MMB, Shaker MA, Abeer AK. 2012.
Antioxidant activities of date pits in a
model meat system. Int Food Res J, 19:
223-227.
Appel LJ, Moore TJ, Obarzanek EW, Vollmer
M, Svetkey LP, Sacks FM, Bray GA, Vogt
TM, Cutler JA, Windhauser MM. 1997. A
clinical trial of the effects of dietary
patterns on blood pressure. N Engl J Med,
336: 1117–1124.
Ardekani MRS, Khanavi M, Hajimahmoodi M,
Jahangiri M, Hadjiakhoondi A. 2010.
Comparison of antioxidant activity and
total phenol contents of some date seed
varieties from Iran. Iran J Pharm Sci, 9:
141-146.
Assirey EAR. 2015. Nutritional composition of
fruit of 10 date palm (Phoenix
dactylifera L.) cultivars grown in Saudi
Arabia. J Taibah Univ
Sci, 9: 75-79.
Baliga MS, Baliga BRV, Kandathilc SM, Bhatd
HP, Vayalil PK. 2011. A review of the
chemistry and pharmacology of the date
fruits (Phoenix dactylifera L.). Food Res
Int, 44: 1812-1822.
Bearlieu KE, McBurney MI. 1992. Changes in
pig serum lipids, nutrient digestibility and
sterol excretion during cecal infusion of
propionate. J Nutr, 122: 241–245.
Besbes S, Blecker C, Deroanne C, Drira NE,
Attia H. 2004. Date seeds: Chemical
composition and characteristic profiles of
the lipid fraction. Food Chem, 84: 577-
584.
Ekmekcioglu C, Elmadfa I, Meyer AL,
Moeslinger T. 2016. The role
of dietary potassium in hypertension and
diabetes. J Physiol Biochem, 72: 93-106.
Freha G, Henchiri C. 2013. Study of the effect
of dates on blood glucose and lipid profile
in healthy human subjects. Int J Pharm
Chem Biol Sci, 3: 826-833.
Gilmore LA, Walzem RL, Crouse SF, Smith
DR, Adams TH, Vaidyanathan V, Cao X,
Smith SB. 2011. Consumption of higholeic acid ground beef increases HDLcholesterol concentration but both highand low-oleic acid ground beef decrease
HDL particle diameter in
normocholesterolemic men. J Nutr, 141:
1188-1194.
Guo M, Liu Y, Gao ZY, Shi DZ. 2014. Chinese
herbal medicine on dyslipidemia: Progress
and perspective. Evid Based
Complementary Altern Med, 2014:
163036.
Hamada JS, Hashim IB, Sharif FA. 2002.
Preliminary analysis and potential uses of
date pits in foods. Food Chem., 76: 135-
137.
Hasan NS, Amon ZH, Nor AI, Mokhtarrudin N,
Esa NM. 2010.
Nutritional composition and in vitro
evaluation of the antioxidants properties of
various dates extracts (Phoenix dactylifera
L.) from Libya.’ Asian J
Clin Nutr, 2: 208-214.
Hertog MGL, Kromhout D, Aravanis C. 1995.
Flavonoid intake and long-term risk of
coronary heart disease and cancer in the
seven countries study. Arch Intern Med,
155: 381-386.
Hong YJ, Tomas-Barberan FA, Kader AA,
Mitchell AE. 2006. The flavonoid
glycosides and procyanidin composition of
Deglet Noor dates (Phoenix dactylifera). J
Agric Food Chem, 54: 2405-2411.
Ishurd O, Zgheel F, Kermagi A, Flefla M,
Elmabruk M. 2004. Antitumor activity of
Nasrullah et al.
AJP, Vol. 13, No. 2, Mar-Apr 2023 152
D-glucan from Libyan dates. J Med Food,
7: 252-255.
Juárez-Rojop IE, Díaz-Zagoya JC, Ble-Castillo
JL, Miranda-Osorio PH, CastellRodríguez AE. 2012. Hypoglycemic effect
of Carica papaya leaves in streptozotocininduced diabetic rats. BMC Complement
Altern Med, 12: 236.
Jung UJ, Lee MK, Park YB, Kang MA, Choi
MS. 2006. Effect of
citrus flavonoids on lipid metabolism and
glucose-regulating enzyme mRNA
levels in type-2 diabetic mice. Int J
Biochem Cell Bio, 38: A1134-A1145.
Khalid S, Ahmad A, Masud T, Asad MJ,
Sandhu M. 2016. Nutritional assessment
of ajwa date flesh and pits in comparison
to local varieties. J Anim Plant Sci, 26:
1072-1080.
Khan MA, Hassan M, Hafizullah M. 2006.
Coronary artery disease, is it more
frequently effecting younger age group
and women? Pakistan Heart Journal, 39: 1-
2.
Kim JH, Hahm DH, Yang DC, Kim JH, Lee HJ,
Shim I. 2005. Effect of crude saponin of
Korean red ginseng on high-fat dietinduced obesity in the rat. J Pharmacol Sci,
97: 124-131.
Kimura H, Ogawa S, Jisaka M, Kimura Y,
Katsube T, Yokota K. 2006. Identification
of novel saponins from edible seeds of
Japanese horse chestnut (Aesculus
turbinata Blume) after treatment with
wooden ashes and their nutraceutical
activity. J Pharm Biomed, 41: 1657-1665.
Megalli S, Davies NM, Roufogalis BD. 2006.
Anti-hyperlipidemic and hypoglycemic
effects of Gynostemma pentaphyllum in
the Zucker fatty rat. J Pharm Pharm Sci, 9:
281-291.
Nordestgaard BG, Varbo A. 2014.
Triglycerides and cardiovascular disease.
Lancet, 384: 626-635.
Rock W, Rosenblat M, Borochov-Neori H,
Volkova N, Judeinstein S, Elias M,
Aviram M. 2009. Effects of date (Phoenix
dactylifera L., Medjool or Hallawi
Variety) consumption by healthy subjects
on serum glucose and lipid levels and on
serum oxidative status: A pilot study.
J Agric Food Chem, 57: 8010-8017.
Shokr EAM, Ibrahim GA, Anwar OA, Salman
DA, Fahad AL, Mohammad AA, Khalid
OA, Njound MA, Rayian A. 2016. Effect
of dates on blood elements, glucose and
lipid in human population Hail, KSA.
Int J Curr Res, 8: 29845-29848.
Stokes KY, Cooper D, Tailor A, Granger DN.
2002. Hypercholesterolemia promotes
inflammation and microvascular
dysfunction: Role of nitric oxide and
superoxide. Free Radic Biol Med, 33:
1026-1036.
Sun BS, Chen YP, Wang YB, Tang SW, Pan
FY, Li Z, Sung CK. 2012. Anti-obesity
effects of mogrosides extracted from the
fruits of Siraitia grosvenorii
(Cucurbitaceae). Afr J Pharm Pharmacol,
6: 1492-1501.
Taniyama Y, Griendling KK. 2003. Reactive
oxygen species in the vasculature:
Molecular and cellular
mechanisms. Hypertension, 42: 1075-
1081.
Usman F, Ahmad B, Hussain S. 2014.
Institutional based prevalence of Ischemic
Heart Disease in Khyber Pakhtunkhwa
Pakistan. JRLMC, 3: 31-35.
Vayalil PK. 2002. Antioxidant and
antimutagenic properties of aqueous
extract of date fruit (Phoenix dactylifera L.
Arecaceae). J Agric Food Chem, 50: 610-
617.
Wilson PW, Zech LA, Gregg RE, Schaefer EJ,
Hoeg JM, Sprecher DL, Brewer Jr HB.
1985. Estimation of VLDL cholesterol in
hyperlipidemia. Clinica Chimica Acta,
151: 285-291.
Zeb F, Safdar M, Fatima S, Khan S, Alam S,
Muhammad M, Syed A, Habib F, Shakoor
H. 2018. Supplementation of garlic and
coriander seed powder: Impact on body
mass index, lipid profile and blood
pressure of hyperlipidemic patients. Pak J
Pharm Sci, 31: 1935-1941.
Zhang CR, Aldosari SA, Vidyasagar PS, Nair
KM, Nair MG. 2013. Antioxidant and antiinflammatory assays confirm bioactive
compounds in Ajwa date fruit. J Agric
Food Chem, 61: 5834-5840
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