Afsharypuor S, San'aty F. 2005. Essential oil
constituents of leaves and fruits of Pinus
eldarica Medw. J essential oil Res, 17: 327-
328.
Aguiar CCT, Almeida AB, Araújo,PVP, Abreu
RNDCD, Chaves EMC, Vale OCD,
Macêdo DS, Woods DJ, Fonteles MMDF,
Vasconcelos SMM. 2012. Oxidative stress
and epilepsy: literature review. Oxid Med
Cell Longev, 2012: 795259.
Asgharzadeh F, Hosseini M, Bargi R, Beheshti
F, Rakhshandeh H, Mansouri S, Aghaei A,
Sadeghnia HR, Anaeigoudari A. 2020.
Effects of hydro-ethanolic extract of
Tanacetum parthenium and its n-butanol and
aqueous fractions on brain oxidative damage
in pentylenetetrazole-induced seizures in
mice. Pharm Sci, 26: 252-260.
Asgharzadeh F, Hosseini M, Bargi R,
Soukhtanloo M, Beheshti F, Mohammady
Z, Anaeigoudari, A. 2019. Effect of
captopril on brain oxidative damage in
pentylenetetrazole-induced seizures in mice.
Pharm Sci, 25: 221-226.
Babaee F, Safaeian L, Zolfaghari B, Javanmard
SH. 2016. Cytoprotective effect of
hydroalcoholic extract of Pinus eldarica
bark against H2O2-induced oxidative stress
in human endothelial cells. Iran Biomed J,
20: 161-7.
Baracskay P, Szepesi Z, Orbán G, Juhász G,
Czurkó A. 2008. Generalization of seizures
parallels the formation of “dark” neurons in
the hippocampus and pontine reticular
formation after focal–cortical application of
4-aminopyridine (4-AP) in the rat. Brain
Res, 1228: 217-228.
Bargi R, Asgharzadehyazdi F, Beheshti F,
Mojatab Mousavi S, Vafadar Langehbiz S,
Rakhshandeh H, Sadeghnia HR, Hosseini,
M. 2017. The effects of hydroalcoholic
extract of Pinus eldarica on hippocampal
tissue oxidative damage in
pentylenetetrazole-induced seizures in rat.
Cur Nutr Food Sci, 13: 50-56.
Beheshti F, Hosseini M, Arab Z, Asghari A,
Anaeigoudari A. 2020. Ameliorative role of
metformin on lipopolysaccharide-mediated
liver malfunction through suppression of
inflammation and oxidative stress in rats.
Toxin Rev, 1-9.
Chuang Y, Chen S, Lin T, Liou C, Chang W,
Chan S, Chang, A. 2007. Upregulation of
nitric oxide synthase II contributes to
apoptotic cell death in the hippocampal CA3
subfield via a cytochrome c/caspase-3
signaling cascade following induction of
experimental temporal lobe status
epilepticus in the rat. Neuropharmacology,
52: 1263-1273.
Ebrahimzadeh-Bideskan AR, Mansouri S,
Ataei ML, Jahanshahi M, Hosseini M. 2018.
The effects of soy and tamoxifen on
apoptosis in the hippocampus and dentate
gyrus in a pentylenetetrazole-induced
seizure model of ovariectomized rats. Anat
Sci Int, 93: 218-230.
Ebrahimzadeh Bideskan AR, Lale Ataei M,
Mansouri S, Hosseini M, 2015. The effects
of tamoxifen and soy on dark neuron
production in hippocampal formation after
pentylenetetrazole-induced repeated
seizures in rats. Pathophysiology, 22: 125-
35.
Forouzanfar F, Ghorbani A, Hosseini M,
Rakhshandeh H. 2016. Hydroalcoholic
extract of needles of Pinus eldarica enhances
pentobarbital-induced sleep: possible
involvement of GABAergic system.
Avicenna J Phytomed, 6: 449-57.
Ghadirkhomi A, Safaeian L, Zolfaghari B,
Ghazvin MRA, Rezaei P. 2016. Evaluation
of acute and sub-acute toxicity of Pinus
eldarica bark extract in Wistar rats.
Avicenna J Phytomed, 6: 558-566.
Ghaffari T, Kafil HS, Asnaashari S, Farajnia S,
Delazar A, Baek SC, Hamishehkar H, Kim
KM. 2019. Chemical composition and
antimicrobial activity of essential oils from
the aerial parts of Pinus eldarica grown in
Northwestern Iran. Molecules, 24: 3203.
Guri A, Kefalas P, Roussis V. 2006.
Antioxidant potential of six pine species.
Phytother Res, 20: 263-266.
Homayoun M, Shafieian R, Seghatoleslam M,
Hosseini M, Ebrahimzadeh-Bideskan A.
2020. Protective impact of Rosa damascena
against neural damage in a rat model of
pentylenetetrazole (PTZ)-induced seizure.
Mansouri et al.
AJP, Vol. 11, No. 6, Nov-Dec 2021 620
Avicenna J Phytomed, 10: 574-583.
Hosseini M, Jafarianheris T, Seddighi N,
Parvaneh M, Ghorbani A, Sadeghnia HR.
Rakhshandeh H. 2012. Effects of different
extracts of Eugenia caryophyllata on
pentylenetetrazole-induced seizures in mice.
Zhong Xi Yi Jie He Xue Bao, 10: 1476-
1481.
Hosseini M, Sadeghnia HR, Salehabadi S,
Alavi H, Gorji A. 2009. The effect of Larginine and L-NAME on
pentylenetetrazole induced seizures in
ovariectomized rats, an in vivo study.
Seizure, 18: 695-698.
Hosseinzadeh H, Khooei AR,
Khashayarmanesh Z, Motamed-Shariaty V.
2010. Antiurolithiatic activity of Pinus
eldarica Medw. fruits aqueous extract in
rats. Urol J, 7: 232-237.
Hou CH. 2011. Pu-Erh tea and GABA
attenuates oxidative stress in kainic acidinduced status epilepticus. J Biomed Sci. 18:
75-80.
Huseini HF, Anvari MS, Rabbani S, Sharifi F,
Arzaghi SM, Fakhrzadeh H. 2015. Antihyperlipidemic and anti-atherosclerotic
effects of Pinus eldarica Medw. nut in
hypercholesterolemic rabbits. Daru, 23: 1-5.
Iravani S, Zolfaghari B. 2014. Phytochemical
analysis of Pinus eldarica bark. Res Pharm
Sci, 9: 243-250.
Ishisaka A, Ichikawa S, Sakakibara H, Piskula
MK, Nakamura T, Kato Y, Ito M, Miyamoto
K, Tsuji A, Kawai Y. 2011. Accumulation
of orally administered quercetin in brain
tissue and its antioxidative effects in rats.
Free Radic Biol Med, 5: 1329-1336.
Jembrek MJ, Vlainic J. 2015. GABA receptors:
Pharmacological potential and pitfalls. Curr
Pharm Des. 21: 4943-4959.
Jortner BS. 2006. The return of the dark neuron.
A histological artifact complicating
contemporary neurotoxicologic evaluation.
Neurotoxicology, 27: 628-634.
Karami R, Hosseini M, Mohammadpour T,
Ghorbani A, Sadeghnia HR, Rakhshandeh
H, Vafaee F, Esmaeilizadeh M. 2015.
Effects of hydroalcoholic extract of
Coriandrum sativum on oxidative damage in
pentylenetetrazole-induced seizures in rats.
Iran J Neurol, 14: 59-66.
Karimzadeh F, Hosseini M, Mangeng D, Alavi
H, Hassanzadeh GR, Bayat M, Jafarian M,
Kazemi H, Gorji A. 2012. Anticonvulsant
and neuroprotective effects of Pimpinella
anisum in rat brain. BMC Complement
Altern Med, 12: 2-9.
Karonen M, Hämäläinen M, Nieminen R, Klika
KD, Loponen J, Ovcharenko VV, Moilanen
E, Pihlaja K. 2004. Phenolic extractives
from the bark of Pinus sylvestris L. and their
effects on inflammatory mediators nitric
oxide and prostaglandin E2. J Agric Food
Chem, 52: 7532-7540.
Kherani ZS, Auer RN. 2008. Pharmacologic
analysis of the mechanism of dark neuron
production in cerebral cortex. Acta
Neuropathol, 116: 447-452.
Kumar A, Nidhi S, Manveen B, Sumitra S.
2016. A review on chemical induced
kindling models of epilepsy. J Vet Med Res,
3: 1-6.
Lee SJ. 2019. Effects of preconditioning
exercise on nitric oxide and antioxidants in
hippocampus of epileptic seizure. J Exerc
Rehabi, 15: 757-762.
Li Z, Jagadapillai R, Gozal E, Barnes G. 2019.
Deletion of semaphorin 3F in interneurons is
associated with decreased GABAergic
neurons, autism-like behavior, and
increased oxidative stress cascades. Mol
Neurobiol. 56: 5520-5538.
Liu C, Zhao L, Yu G. 2011. The dominant
glutamic acid metabolic flux to produce γamino butyric acid over proline in Nicotiana
tabacum leaves under water stress relates to
its significant role in antioxidant activity. J
Integr Plant Biol, 53: 608-618.
Mansouri S, Lale Ataei M, Hosseini M,
Bideskan ARE. 2013. Tamoxifen mimics
the effects of endogenous ovarian hormones
on repeated seizures induced by
pentylenetetrazole in rats. Exp Neurobiol,
22: 116-123.
Mathern G, Mendoza D, Lozada A, Pretorius J,
Dehnes Y Danbolt N, Nelson N, Leite JP,
Chimelli L, Born DE. 1999. Hippocampal
GABA and glutamate transporter
immunoreactivity in patients with temporal
lobe epilepsy. Neurology, 52: 453-453.
Munguía-Martínez MF, Nava-Ruíz C, RuízDíaz A, Díaz-Ruíz A, Yescas-Gómez P,
Méndez-Armenta M. 2019.
Immunohistochemical study of antioxidant
enzymes regulated by Nrf2 in the models of
epileptic seizures (KA and PTZ). Oxid Med
Cell Longev, 2019: 1327986.
Nowak A, Florkowska K, Zielonka-Brzezicka
J, Duchnik W, Muzykiewicz A, Klimowicz
A. 2021. The effects of extraction
Neuroprotective effects of Pinus eldarica
AJP, Vol. 11, No. 6, Nov-Dec 2021 621
techniques on the antioxidant potential of
extracts of different parts of milk thistle
(Silybum marianum L.). Acta Sci Pol
Technol Aliment, 20: 37-46.
Ooigawa H, Nawashiro H, Fukui S, Otani N,
Osumi A, Toyooka T, Shima K. 2006. The
fate of Nissl-stained dark neurons following
traumatic brain injury in rats: difference
between neocortex and hippocampus
regarding survival rate. Acta Neuropathol,
112: 471-481.
Pourmotabbed A, Nedaei S, Cheraghi, M,
Moradian S, Touhidi A, Aeinfar M, Seyfi Z,
Pourmotabbed T. 2011. Effect of prenatal
pentylenetetrazol-induced kindling on
learning and memory of male offspring.
Neuroscience, 172: 205-211.
Pourzaki M, Homayoun M, Sadeghi S,
Seghatoleslam M, Hosseini M,
Ebrahimzadeh Bideskan A. 2017.
Preventive effect of Coriandrum sativum on
neuronal damages in pentylentetrazoleinduced seizure in rats. Avicenna J
Phytomed, 7: 116-128.
Puttachary S, Sharma S, Stark S, Thippeswamy
T. 2015. Seizure-induced oxidative stress in
temporal lobe epilepsy. Biomed Res Int,
2015: 745613.
Sadeghi M, Zolfaghari B, Jahanian-Najafabadi
A, Abtahi SR. 2016. Anti-pseudomonas
activity of essential oil, total extract, and
proanthocyanidins of Pinus eldarica Medw.
bark. Res Pharm Sci, 11: 58-64.
Sarvmeili N, Jafarian-Dehkordi A, Zolfaghari
B. 2016. Cytotoxic effects of Pinus eldarica
essential oil and extracts on HeLa and MCF7 cell lines. Res Pharm Sci, 11: 476-483.
Seghatoleslam M, Alipour F, Shafieian R,
Hassanzadeh Z, Edalatmanesh MA,
Sadeghnia HR, Hosseini M. 2016. The
effects of Nigella sativa on neural damage
after pentylenetetrazole induced seizures in
rats. J Tradit Complement Med, 6: 262-268.
Serejo F, Emerit I, Filipe PM, Fernandes AC,
Costa MA, Freitas JP, De Moura MC. 2003.
Oxidative stress in chronic hepatitis C: the
effect of interferon therapy and correlation
with pathological features. Can J
Gastroenterol, 17: 644-650.
Shin HJ, Jeong E, Lee JY, An HS, Jang HM,
Ahn YJ, Lee J, Kyung Eun K, Gu Seob R.
2021. Lipocalin-2 deficiency reduces
oxidative stress and neuroinflammation and
results in attenuation of kainic acid-induced
hippocampal cell death. Antioxidants, 10: 1-
13.
Solati K, Rabiei Z, Asgharzade, S, AminiKhoei H, Hassanpour A, Abbasiyan Z,
Anjomshoa M, Rafieian-Kopaei M. 2019.
The effect of pretreatment with
hydroalcoholic extract of Alpinia
officinarum rhizome on seizure severity and
memory impairment in pentylenetetrazolinduced kindling model of seizure in rat [J].
Neuroscience, 6: 128-145.
Vafaee F, Hosseini M, Hassanzadeh Z,
Edalatmanesh MA, Sadeghnia HR,
Seghatoleslam M, Mousavi SM, Amani A.
2015. The effects of Nigella sativa hydroalcoholic extract on memory and brain
tissues oxidative damage after repeated
seizures in rats. Iran J Pharm Res, 14: 547-
557.
Xu J, Zhan T, Zheng W, Huang YK, Chen K,
Zhang XH, Ren P, Huang X. 2020.
Hydroxysafflor yellow A acutely attenuates
blood-brain barrier permeability, oxidative
stress, inflammation and apoptosis in
traumatic brain injury in rats1. Acta Cir
Bras, 35: e351202.
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