Effect of ointment-based egg white on healing of second- degree wound in burn patients: a triple-blind randomized clinical trial study

Document Type : Original Research Article

Authors

1 Nursing Care Research Center in Chronic Diseases, Nursing and Midwifery School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Nursing and Midwifery School, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

3 Department of Plastic Surgery, Taleghani Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

4 Medical Plants Research Center and Department of Pharmacology, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, Iran.

5 Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Abstract

Objective: Burn wound healing is one of the problems of medical sciences and it is of great importance to find a drug or substance that can heal burn wounds with minimum complications. The present study aimed to evaluate the effect of ointment-based egg white on healing second-degree burn wounds.
Materials and Methods: In the present triple-blind clinical trial, a total of 90 patients from Taleghani hospital, Ahvaz, Iran were selected and randomly divided into two groups based on the inclusion criteria. The intervention group was dressed with egg white formulation + silver sulfadiazine cream and the control group was treated with placebo + silver sulfadiazine cream. The burn wound healing process was evaluated on days 1, 7 and 15 by the Bates-Jensen wound assessment tool.
Results: The mean scores of wound healing were decreased (13.75±1.83) in the intervention group when compared to the control (21.51±5.7) on day 15 (p<0.001). The mean duration of wound healing, wound depth, edges, undermining, necrotic tissue, amount of necrosis, exudate type and amount, surrounding skin color, wound induration, peripheral edema, granulation, and epithelialization were significantly decrease in intervention group in comparison with control (p<0.001).
Conclusion: The findings of this research showed that egg whites formulation is an appropriate treatment for burn wound healing, reduced above-noted burn wounds’ variables. It seems that this treatment, along with the common medicine, improves chronic wound recovery rate and patients’ health status.

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References

Aalaa M, Malazy OT, Sanjari M, Peimani M, Mohajeri-Tehrani M. 2012. Nurses’ role in diabetic foot prevention and care; a review. J Diabetes Metab Disord, 11: 24-30.
Alia Sadiq MQH, Gulshan Ara T, Ambreen J. 2018. Effects of essential amino acid “Tryptophan” in post burn skin wound healing. Int J Biosci, 12: 147-153.
Arthur M. 2014. Institute for health metrics and evaluation. Nursing Standard, 28: 32-39.
Bahramsoltani R, Farzaei MH, Rahimi R. 2014. Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. Arch Dermatol Res, 306: 601-617.
Bang RL, Dashti H. 1995. Keloid and hypertrophic scars: trace element alteration. Nutrition (Burbank, Los Angeles County, Calif.), 11: 527-531.
Brunner LS, Smeltzer SCC, Bare BG, Hinkle JL, Cheever KH. 2010. Brunner & Suddarth's textbook of medical-surgical nursing: Lippincott Williams & Wilkins, 149.
Bunyan J. 1983. Perspectives in primary care: The treatment of burns by hypochlorite solution. J Trop Pediatr, 29: 93-94.
Canapp SO, Farese JP, Schultz GS, Gowda S, Ishak AM, Swaim SF, Vangilder J, Lee‐Ambrose L, Martin FG. 2003. The effect of topical tripeptide‐copper complex on healing of ischemic open wounds. Vet Surg, 32: 515-523.
Chai J, Guo Z, Sheng Z. 1995. Protective effects of vitamin E on impaired neutrophil phagocytic function in patients with severe burn. Chin J Plast Surg Burn, 11: 32-35.
Darvishpour A, Lotfi M, Salehi F, Aghazadeh A, Aali N. 2007. Comparing dressing with silver sulfadiazine and nitrofurazone on burn wound infection among the patients admitted to the pediatric burn ward in Tabriz, 2005. J Guilan Univ Med Sci, 15: 42-49.
Dreizen S. 1979. Nutrition and the immune response--a review. Int J Vitam Nutr Res, 49: 220-228.
Dunn K, Edwards-Jones V. 2004. The role of Acticoattm with nanocrystalline silver in the management of burns. Burns J, 30: S1-S9.
Fernandez ML. 2010. Effects of eggs on plasma lipoproteins in healthy populations. J Food Funct, 1: 156-160.
Ge K, Lu S, Qing C, Xie T, Niu Y, Rong L, Wang M, Lin W, Jin S, Hua L. 2003. A study on the promoting effect of l-arginine on the burn wound healing of the rats with diabetes. Chin J Burn, 19: 11-14.
Harlow CR. 2013. A critical analysis of healing touch for depression and anxiety: Citeseer, 90.
Hasanzadeh G, Mehdikhanloo N. 1983. The effect of compound of Brassica Oleracea L. and egg-white on burn wound healing in rat. J Sabzevar Univ Med Sci, 11: 6-12.
Hasanzadeh G, Nouri A, Hajiabadi M, Soltan K, Javadi A. 2005. The effect of egg yolk on burn wound healing in Rats. J Gorgan Univ Med Sci, 7: 6-10.
Ianev E, Radev S, Balutsov M, Klouchek E, Popov A. 1995. The effect of an extract of sea buckthorn (Hippophae rhamnoides L.) on the healing of experimental skin wounds in rats. Khirurgiia, 48: 30-33.
Imani B, Kkermanshahi S, MoosaviI S. 2010. To compaare effect of hydrocolloid dressing and1% silver sulfadiazine  dressing on burn status wounds in patients  with second- degree burn. Daneshvar Med, 16: 63-70.
Kelly ER, Plat J, Haenen GR, Kijlstra A, Berendschot TT. 2014. The effect of modified eggs and an egg-yolk based beverage on serum lutein and zeaxanthin concentrations and macular pigment optical density: results from a randomized trial. PloS one, 9: e92659.
Knighton DR, Ciresi KF, Fiegel VD, Austin LL, Butler EL. 1986. Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann surg, 204: 322-330.
Lakshmi R, Lakshmi A, Bamji MS. 1989. Skin wound healing in riboflavin deficiency. Biochem Med Metab Biol, 42: 185-191.
Mathers C, Fat DM, Boerma JT. 2008. The global burden of disease: 2004 update: World Health Organization^
Mathus-Vliegen EM. 2004. Old age, malnutrition, and pressure sores: an ill-fated alliance. J Gerontol A Biol Sci Med Sci, 59: M355-M360.
Morley JE, Silver AJ. 1995. Nutritional issues in nursing home care. Ann Inte Med, 123: 850-859.
Organization WH. 2002. WHO traditional medicine strategy 2002-2005.
Rastegar F AN, Amiri M,  Azarpira A. 2011. The effect of egg yolk oil in the healing of third degree burn wound in rats. Iran Red Crescent Med J, 13: 739-743.
Sieradzki E, Olejarz E, Strauss K, Marzec A, Mieszkowska M, Kałuzny J. 1998. The effect of selenium and vitamin E on the healing process of experimental corneal lesions in the eye of the rabbit. Klin oczna, 100: 85-88.
Sood R, Achauer B. 2006. Burn Surgery reconstruction and rehabilitation. Saunders. Elsevier. 436.
Thomas DR, Goode PS, LaMaster K, Tennyson T. 1998. Acemannan hydrogel dressing versus saline dressing for pressure ulcers: a randomized, controlled trial. Adv Skin Wound Care, 11: 273-276.
van Henegouwen GMB, Junginger HE, de Vries H. 1995. Hydrolysis of RRR-α-tocopheryl acetate (vitamin E acetate) in the skin and its UV protecting activity (an in vivo study with the rat). J Photochem Photobiol B Biol, 29: 45-51.
Wasiak J, Cleland H, Campbell F. 2008. Dressings for superficial and partial thickness burns. Cochrane Database Syst Rev: CD002106.
Avicenna Journal of Phytomedicine
Volume 9, Issue 3
May and June 2019
Pages 260-270

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