TY - JOUR ID - 19811 TI - Effects of gallic acid on intraperitoneal adhesion bands in rats JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Hashemzaei, Mahmoud AU - Tabrizian, kaveh AU - Koohkan, Mohammad Javad AU - Khoshsima Shahraki, Mehdi AU - Rezaee, Ramin AU - Ghorani, Vahideh AU - Shahraki, Jafar AD - Department of Pharmacology and Toxicology, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran AD - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran AD - Department of Pathology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran AD - International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Pharmacodynamics and Toxicology, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran Y1 - 2022 PY - 2022 VL - 12 IS - 4 SP - 337 EP - 345 KW - Gallic acid KW - Adhesion bands KW - TNF-α KW - Lipid Peroxidation DO - 10.22038/ajp.2022.19811 N2 - Objective: Gallic acid (GA) is an organic acid that possesses anti-inflammatory effects as it inhibits the production of metalloproteinases, tissue plasminogen activator, growth factors and adhesion molecules. Since formation of abdominal surgery-induced adhesion bands is accompanied by inflammation, angiogenesis and cell proliferation, in the current study, we assessed potential beneficial properties of GA against adhesion bands formation in rats.Materials and Methods: Thirty-six adult male rats were assigned into six groups of six animals. After induction of anesthesia, peritoneal injury was induced using a standard method and animals received either GA (10, 25, 50 and 100 mg/kg), or normal saline, while a group of rats remained intact. Seven days after the surgery, animals were decapitated and samples were collected for pathology evaluations. Also, lipid peroxidation (TBARS) and tumor necrosis factor alpha (TNF-α) levels were determined in serum samples.Results: Our results showed that GA significantly reduced lipid peroxidation in serum samples but had no effect on TNF-α levels. Furthermore, microscopic and macroscopic injuries reduced significantly in GA-treated animals.Conclusion: Since GA reduced adhesion bands formation at microscopic and macroscopic levels, it could be considered a treatment against adhesion bands formation. UR - https://ajp.mums.ac.ir/article_19811.html L1 - https://ajp.mums.ac.ir/article_19811_a120da5008daa95631a099552743a4ea.pdf ER -