Objectives: Evaluation of therapeutic effects of Carum copticum (C. copticum) has been the subject of several studies in recent years. Thymol the major component of C. copticum is a widely known anti-microbial agent. In this study, the antibacterial and anti viral activities of essential oil of C. copticum fruit were determined.
Materials and Methods: Essential oil of C. copticum was analyzed by means of gas chromatography-mass spectrometry (GC-MS). The antimicrobial activity of the oil was evaluated against six Gram (+/-) bacteria and fungi, using the micro broth dilution technique. Antiviral activity of the essential oil was evaluated using a Bacillus phage CP51.
Results: From the ten identified constituents, representing 98.7% of the oil, thymol (72.3%), terpinolene (13.12%) and o-cymene (11.97%) were the major components. It was found that the oil exhibited strong antimicrobial activity againstStaphylococcus aureus(S. aureus) andBacillus subtilis(B. subtilis) (MIC, 0.00025% v/v). Furthermore, the antiviral activity of the oil was evaluated by plaque reduction assay.
Conclusion: The essential oil showed an antiviral activity against phage when phage was pre-incubated with the essential oil prior to its exposure to B. cereus and without any pre-incubation with the phage, suggesting that the oil directly inactivated virus particles.
Kazemi Oskuee, R., Behravan, J. & Ramezani, M. (2011). Chemical composition, antimicrobial activity and antiviral activity of essential oil of Carum copticum from Iran. Avicenna Journal of Phytomedicine, 1(2), 83–90. https://doi.org/10.22038/ajp.2011.126
MLA
Kazemi Oskuee, R., Behravan, J., & Ramezani, M. "Chemical composition, antimicrobial activity and antiviral activity of essential oil of Carum copticum from Iran", Avicenna Journal of Phytomedicine, 1, 2, 2011, 83–90. doi: 10.22038/ajp.2011.126
HARVARD
Kazemi Oskuee, R., Behravan, J., & Ramezani, M. (2011). 'Chemical composition, antimicrobial activity and antiviral activity of essential oil of Carum copticum from Iran', Avicenna Journal of Phytomedicine, 1(2), pp. 83–90. doi: 10.22038/ajp.2011.126
CHICAGO
Kazemi Oskuee, R., Behravan, J. & Ramezani, M., "Chemical composition, antimicrobial activity and antiviral activity of essential oil of Carum copticum from Iran." Avicenna Journal of Phytomedicine, 1 2 (2011): 83–90, doi: 10.22038/ajp.2011.126
VANCOUVER
Kazemi Oskuee R., Behravan J., Ramezani M. Chemical composition, antimicrobial activity and antiviral activity of essential oil of Carum copticum from Iran. Avicenna Journal of Phytomedicine. 2011;1(2):83–90. doi: 10.22038/ajp.2011.126
