<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Avicenna Journal of Phytomedicine</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ajp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2228-7930</journal_id_issn>
			<journal_id_issn_online>2228-7949</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>9</month>
				<day>1</day>
			</pubdate>
			<volume>16</volume>
			<number>5</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Therapeutic effects of Zataria multiflora Boiss. extract-loaded chitosan nanoparticles against asthma in rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Short communication</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Asthma is one of the most common chronic inflammatory disorders worldwide. Zataria multiflora Boiss., widely used in herbal medicine, shows potential efficacy against asthma. In this study, Z. multiflora was encapsulated in chitosan nanoparticles to improve its therapeutic effectiveness against asthma in rats.Materials and Methods: Thirty-six rats were divided to 6 groups including control, asthma (sensitized to ovalbumin (OVA)), and asthmatic groups treated with dexamethasone, empty nano-chitosan, and 8 and 80 mg/kg nano Z. multiflora hydroalcoholic extract (Herbarium No: 35314, FUMH) through inhalation. Superoxide dismutase (SOD) and catalase (CAT) activities, malondialdehyde (MDA) concentration, total white blood cells (WBC) counts, interferon-gamma (IFN-γ), interleukin-4 (IL-4) and IFN-γ to IL-4 ratio in bronchoalveolar lavage fluid (BALF) and tracheal responsiveness were assessed.Results: Nano Z. multiflora treatment significantly reduced WBC count and levels of MDA and IL-4 compared to the asthma group. Also, the nano extract of Z. multiflora caused a protective effect on elevated tracheal responsiveness to methacholine and ovalbumin.Conclusion: The therapeutic efficacy of Z. multiflora can potentially be enhanced through targeted delivery using chitosan nanoparticles administered via inhalation in asthmatic rats.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Asthma, Zataria multiflora Boiss, Nanotechnology, Chitosan, Rat</keyword>
				<start_page>798</start_page>
				<end_page>810</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26641.html</web_url>
			<author_list><author>
				<first_name>najmeh</first_name>
				<middle_name></middle_name>
				<last_name>parvaz</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>najmehparvaz@gmail.com</email>
				<code>116951</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mahboubeh</first_name>
				<middle_name></middle_name>
				<last_name>Mirhosseini</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>m.mirhosseini@pnu.ac.ir</email>
				<code>116952</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biology, Payame Noor University, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Saeideh</first_name>
				<middle_name></middle_name>
				<last_name>Saadat</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>saadats@zaums.ac.ir</email>
				<code>116953</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>fatemeh</first_name>
				<middle_name></middle_name>
				<last_name>Amin</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ft.amin@yahoo.com</email>
				<code>116954</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Physiology‐Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Leila</first_name>
				<middle_name></middle_name>
				<last_name>Etemad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>etemadi@mums.ac.ir</email>
				<code>116955</code>
				<coreauthor>No</coreauthor>
				<affiliation>International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Clinical and laboratory findings in patients with castor bean (Ricinus communis L.) poisoning referred to Imam Reza hospital in northeast of Iran, from April 2015 to March 2020</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Short communication</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Castor bean (CB) (Ricinus communis) contains a highly toxic natural compound called ricin. We retrospectively reviewed the documents of CB-poisoned cases referred to the clinical toxicology department of Imam Reza Hospital affiliated with Mashhad University of Medical Sciences, Mashhad, Iran.Materials and Methods: Patients’ data including epidemiological variables, rout and amount of CB ingestion, clinical and laboratory findings, and type of treatment were extracted from hospital documents.Results: Twelve cases of CB ingestion, with mean age 29.42±21.19 years (4 to 70 years), 4 children (33.3%), and two elderly people (16.7%), were included in the study. All of them were intoxicated by oral ingestion of CB. The mean number of ingested CBs was 4.83±3.16 seeds (range 1-10, median 5 seeds). The most common complaint of the cases (n=11, 91.67%) was frequent vomiting, followed by nausea (n=7, 41.7%) and diarrhea (n=4, 33.3%). Vomiting more commonly occurred up to the second hour after seeds ingestion and at a frequency of 8 to 21 times. The vital signs of all cases were in normal ranges and no tachycardia, hypotension, or tachypnea was recorded. Also, all laboratory results were normal, except metabolic acidosis (pH 7.3) in one case (8.3%). All cases were discharged in good condition with conservative treatment after 19.5±15.3 hr (12-45 hr, median=22 hr). None of them reported any problem in follow-up.Conclusion: The majority of our cases were mild. Gastrointestinal problems, especially frequent vomiting, were the most common complaints. Conservative management was effective in mild to moderate cases.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Ricin, Castor Bean, Herbal, Poisoning, vomiting</keyword>
				<start_page>811</start_page>
				<end_page>818</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26942.html</web_url>
			<author_list><author>
				<first_name>Mohammad</first_name>
				<middle_name></middle_name>
				<last_name>Moshiri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>moshirim@mums.ac.ir</email>
				<code>118270</code>
				<coreauthor>No</coreauthor>
				<affiliation>Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yeganeh</first_name>
				<middle_name></middle_name>
				<last_name>Ramazani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ygnoramezani.7797@yahoo.com</email>
				<code>118271</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Nilofar</first_name>
				<middle_name></middle_name>
				<last_name>Akhgari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>akhgarin761@mums.ac.ir</email>
				<code>118272</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Bita</first_name>
				<middle_name></middle_name>
				<last_name>Dadpour</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dadpourb@mums.ac.ir</email>
				<code>118273</code>
				<coreauthor>No</coreauthor>
				<affiliation>Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Leila</first_name>
				<middle_name></middle_name>
				<last_name>Etemad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>etemadl@mums.ac.ir</email>
				<code>118274</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Impact of green tea on obesity-related hormones in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Menopause leads to hormonal changes that increase visceral fat, raising risks for metabolic disorders and breast cancer due to altered adipocytokine levels. Green tea (Camellia sinensis L.), containing catechins like EGCG (epigallocatechin gallate), may improve metabolic health in postmenopausal women. In this review we assessing the effects of green tea consumption on key obesity related hormones in postmenopausal women.Materials and Methods: This study reviewed randomized controlled trials (RCTs) from PubMed, Science Direct, Cochrane Library, and Google Scholar up to March 2024, focusing on green tea’s effects on leptin, adiponectin, ghrelin, and insulin. Eight RCTs with 632 participants were analyzed using standardized mean differences (SMDs) with 95% confidence intervals (CIs) in a random-effects model. Heterogeneity was measured with the I² statistic, and publication bias was assessed via Egger’s test and funnel plots.Results: Green tea significantly reduced ghrelin levels (SMD: -4.63, 95% CI: -8.44 to -0.82, p = 0.02, I² = 98.98%), particularly at doses &gt;1000 mg/day and durations &gt;8 weeks. No significant effects were observed for leptin (SMD: -0.33, 95% CI: -0.89 to 0.22, p = 0.24), adiponectin (SMD: -0.53, 95% CI: -1.44 to 0.39, p = 0.26), or insulin (SMD: -0.87, 95% CI: -4.31 to 2.58, p = 0.62). Subgroup analyses revealed significant reductions in leptin at doses &gt;1000 mg/day, durations ≤8 weeks, and BMI &lt;29 kg/m²; adiponectin at 400–1000 mg/day and insulin at durations ≤8 weeks and BMI &lt;29 kg/m². High heterogeneity and some evidence of publication bias were noted. Conclusion: Green tea notably reduced ghrelin, with context-specific effects on leptin, adiponectin, and insulin based on dose, duration, and body mass index (BMI), suggesting tailored benefits for postmenopausal women’s metabolic health.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>green tea, Postmenopause, ghrelin, Leptin, Adiponectin, Insulin</keyword>
				<start_page>819</start_page>
				<end_page>833</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26841.html</web_url>
			<author_list><author>
				<first_name>Sahar</first_name>
				<middle_name></middle_name>
				<last_name>Ghoflchi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ghoflchi.s75@gmail.com</email>
				<code>117828</code>
				<coreauthor>No</coreauthor>
				<affiliation>Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hossein</first_name>
				<middle_name></middle_name>
				<last_name>Hosseini</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>h_hosseini121@yahoo.com</email>
				<code>117829</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sajad</first_name>
				<middle_name></middle_name>
				<last_name>Rafiee</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sajadrafiee@gmail.com</email>
				<code>117830</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ghader</first_name>
				<middle_name></middle_name>
				<last_name>Babaei</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ghaderbabaei@gmail.com</email>
				<code>117831</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Majid</first_name>
				<middle_name></middle_name>
				<last_name>Effati</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>effatim4011@mums.ac.ir</email>
				<code>117832</code>
				<coreauthor>No</coreauthor>
				<affiliation>Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mahdieh</first_name>
				<middle_name></middle_name>
				<last_name>Aliyari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>aliyarim4001@mums.ac.ir</email>
				<code>117833</code>
				<coreauthor>No</coreauthor>
				<affiliation>Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Reyhane</first_name>
				<middle_name></middle_name>
				<last_name>Ghayour vatanparast</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ghayourvr4022@mums.ac.ir</email>
				<code>117834</code>
				<coreauthor>No</coreauthor>
				<affiliation>Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Masoud</first_name>
				<middle_name></middle_name>
				<last_name>Imani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>masoudimani7@gmail.com</email>
				<code>117835</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Masoumeh</first_name>
				<middle_name></middle_name>
				<last_name>Rajabibazl</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hoseinihs@mums.ac.ir</email>
				<code>117836</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Synergistic effects of herbal extracts and nanoparticles in skin damage repair: A comprehensive review</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Today, applying herbal extracts to treat skin damage has become widespread and it is supported by numerous studies that confirmed their effectiveness. Due to fewer side effects, diversity of active compounds in them, and lower costs, herbal extracts are an important therapeutic method for skin lesions. additionally, nanoparticles are important for stimulating the body&#039;s ability to recover and treat wounds.Materials and Methods: This review article aims to evaluate how combining herbal extracts with nanoparticles and advanced drug carriers (like liposomes and nanofibers) creates synergistic effects that enhance the treatment of bacterial skin infections and wounds. By improving bioavailability, targeting delivery, and reducing required dosages, these formulated combinations offer a more effective, faster-healing, and potentially safer alternative to conventional therapies.Results: Based on the discussed studies, therapy using a combination of medicinal herbs and nanotechnology increases the effectiveness of treatment, accelerates recovery, and decreases the use of each material, thereby reducing the toxicity of each in infection and skin damage treatment.Conclusion: This review conclusively demonstrates that the strategic formulation of herbal extracts with nanoparticles and advanced drug carriers—such as liposomes, nanofibers, and polymeric nanoparticles—unlocks unprecedented synergistic potential for treating bacterial skin infections and accelerating wound and burn healing. By enhancing bioavailability, enabling targeted delivery, and reducing therapeutic doses (thereby minimizing toxicity), these nano-herbal hybrids represent a paradigm shift toward safer, faster, and more cost-effective regenerative therapies that can combat antibiotic resistance and revolutionize modern dermatological care.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Formulated herbal extracts, Application, Treatment, Skin damage, Nanoparticle</keyword>
				<start_page>834</start_page>
				<end_page>848</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26851.html</web_url>
			<author_list><author>
				<first_name>Somaieh</first_name>
				<middle_name></middle_name>
				<last_name>Sabzali</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sabzali.s@lu.ac.ir</email>
				<code>117877</code>
				<coreauthor>No</coreauthor>
				<affiliation>, Department of Biology, Faculty of Basic Sciences, Lorestan University, Khorramabad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Seifollah</first_name>
				<middle_name></middle_name>
				<last_name>Bahramikia</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>bahramikia.s@lu.ac.ir</email>
				<code>117878</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biology, Faculty of Basic Sciences, Lorestan University, Khorramabad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>kiana</first_name>
				<middle_name></middle_name>
				<last_name>Shahzamani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>shahzamani.k@lums.ac.ir</email>
				<code>117879</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Hepatitis Research Center, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Lycopene suppresses α-cypermethrin nephrotoxicity: An insight into its modulatory effect on oxidative stress-mediated pro-inflammation, DNA damage and caspase apoptosis in Wistar rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Cypermethrin (CPM) is a synthetic pyrethroid pesticide with ubiquitous use in agriculture, but well associated with nephrotoxicity induction. However, CPM exposure is linked with human and animal systemic toxicity. Lycopene (LYP) is a lipid-soluble potent antioxidant abundant in tomatoes. The investigation thus explored whether LYP could mitigate CPM-induced nephrotoxicity via related mechanisms.Materials and Methods: The study design featured 4 groups: Control, LYP (10 mg/kg/day), CPM (25 mg/kg bw /day) and LYP (10 mg/kg bw /day) + CPM (25 mg/kg bw /day). The treatments of LYP and CPM were given for consecutive 28 days . Urea, uric acid and creatinine levels were estimated in serum, while glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) activities, and malondialdehyde (MDA), DNA damage, cytokines, interleukin-10 (IL-10), interleukin-6 (IL-6), interleukin-4 (IL-4), and tumor necrosis factor-α (TNF-α), caspase-9 and caspase-3 levels were estimated in the renal tissue sample. Histopathology and its amelioration were analyzed.Results: The sub-acute CPM exposure provoked renal damage with significantly elevated levels of creatinine, uric acid, and urea. Renal antioxidant homeostasis was markedly impaired via depressed GPx, CAT, and SOD renal activities, and increased MDA level. Marked DNA damage and profound increases in the renal levels of caspase-9, IL-6, TNF-α, and caspase-3 were found, whereas the renal IL-4 and IL-10 levels were evidently reduced in comparison to the control. Interestingly, the LYP co-administration abrogated the CPM-induced oxidative stress, proinflammation, apoptosis, and DNA fragmentation.Conclusion: Our findings indicate that LYP supplementation may protect the kidney from oxidative stress-related attacks of CPM.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Lycopene, Cypermethrin, Nephrotoxicity, Histopathology, Toxicity, Pesticides, Cytokines</keyword>
				<start_page>849</start_page>
				<end_page>859</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26640.html</web_url>
			<author_list><author>
				<first_name>Hany</first_name>
				<middle_name></middle_name>
				<last_name>Elsawy</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hany.mostafa@science.tanta.edu.eg</email>
				<code>116947</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Chemistry department, Faculty of Science, Tanta  University</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>nourah</first_name>
				<middle_name></middle_name>
				<last_name>almulhim</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nmalmulhim@kfu.edu.sa</email>
				<code>116948</code>
				<coreauthor>No</coreauthor>
				<affiliation>Chemistry department, Faculty of Science, king faisal university</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>manal</first_name>
				<middle_name></middle_name>
				<last_name>alfwuaires</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>malfwuaires@kfu.edu.sa</email>
				<code>116949</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>azza</first_name>
				<middle_name>أا</middle_name>
				<last_name>sedky</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>azza.seadky@alexu.edu.eg</email>
				<code>116950</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Evaluation of the effects of Asparagus racemosus extract (ARova5X) supplementation on postmenopausal discomfort</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Menopause is a critical physiological transition often associated with a spectrum of health challenges such as sexual dysfunction, vasomotor symptoms, and increased oxidative stress. This study aimed to evaluate the efficacy of a hydroalcoholic extract of Asparagus racemosus root (ARova5X), standardized to contain 5% shatavarins, in improving health outcomes among postmenopausal women.Materials and Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted at Apollo Hospitals, Hyderabad, India, during January 2024-2025. A total of 214 postmenopausal women were randomly assigned to receive either ARova5X (250 mg/day) or placebo for 90 days (n=107 per group). Outcome measures were assessed at baseline and post-intervention using validated tools including the Sexual Quotient-Female (SQ-F) questionnaire, the Female Intervention Efficacy Index (FIEI), oxidative stress markers, and anthropometric parameters. Primary endpoints included changes in sexual function, menopausal symptoms, oxidative stress, and weight-related measures.Results: Participants receiving ARova5X showed significant improvements in multiple domains of sexual function including desire (p&lt;0.001), foreplay (p=0.002), arousal (p&lt;0.001), and satisfaction (p=0.004) compared to the placebo group. Vaginal lubrication improved by 84.11% in the intervention group compared to 13.08% in the placebo group. Oxidative stress levels were markedly reduced, with 39.25% of women in the ARova5X group reaching minimal stress levels. Clinical obesity prevalence decreased from 42.99% to 29.91%. Menopausal symptoms such as hot flashes, fatigue, and irritability were also significantly alleviated.Conclusion: ARova5X appears to be a safe, effective natural intervention for improving sexual health, reducing oxidative stress, and supporting weight management in postmenopausal women.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Menopause, Asparagus racemosus, Sexual dysfunction, Oxidative stress, Phytotherapy</keyword>
				<start_page>860</start_page>
				<end_page>872</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26850.html</web_url>
			<author_list><author>
				<first_name>Kumar Guru</first_name>
				<middle_name></middle_name>
				<last_name>Mishra</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>drguru1990@gmail.com</email>
				<code>117869</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Community Medicine, Apollo Institute of Medical Sciences and Research, Hyderabad,Telengana, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Nabnita</first_name>
				<middle_name></middle_name>
				<last_name>Patnaik</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nabnitapatnaik@gmail.com</email>
				<code>117870</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Obs and Gynaecology, AIIMS Bibinagar, Hyderabad, Telengana, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Adityananda</first_name>
				<middle_name></middle_name>
				<last_name>Mohapatra</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>aditya.realruler@gmail.com</email>
				<code>117871</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Urology, SCB Medical College and Hospital, Cuttack</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Nihar Ranjhan</first_name>
				<middle_name></middle_name>
				<last_name>Pradhan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>drniharpradhan@yahoo.co.in</email>
				<code>117872</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Vascular and Endovascular Surgery, AIG Hospitals, Hyderabad, Telengana, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Multi-target healing mechanisms of Hippobroma longiflora for diabetic wounds: A comprehensive network pharmacology study, molecular docking, and experimental insights</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: This research investigated the multi-target mechanisms of Hippobroma longiflora (HL) in promoting diabetic wound healing using an integrated approach involving network pharmacology, molecular docking, and both in vitro and in vivo evaluations.Materials and Methods: The bioactive compounds of HL leaves’ 70% ethanol extract were detected using liquid chromatography–high-resolution mass spectrometry (LC-HRMS), and potential targets were predicted via the SwissTargetPrediction. Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analyses were conducted using DAVID. Molecular docking was predicted using MOE version 2015.10. In vitro assays using HaCaT cells evaluated proliferation and Tumor Necrosis Factor-alpha (TNF-α) levels via ELISA. In vivo measurement in diabetic rats induced by streptozotocin (n = 9 per group), with histopathological analysis conducted on days 7, 14, and 21.Results: HL extract exhibited anti-inflammatory and pro-proliferative effects, primarily mediated by syringic acid (P41) and vanillactic acid (P43). These compounds upregulated AKT1, MAPK3, and HIF-1α. HL treatment significantly enhanced HaCaT cell proliferation (p &lt; 0.0001) and reduced TNF-α level at 31.25 ppm (p &lt; 0.05). In vivo, HL treatment decreased inflammatory cell infiltration from day 7, with significant tissue regeneration observed by day 14 (p &lt; 0.01) relative to base control.Conclusion: HL and its bioactive constituents demonstrate promising potential for diabetic wound healing by modulating inflammatory mediators (TNF-α) and enhancing key regenerative pathways (AKT1, MAPK3, and HIF-1α).]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Diabetic wound healing Herbal medicine Network pharmacology AKT1 TNF, &amp;alpha, HIF, 1&amp;alpha</keyword>
				<start_page>873</start_page>
				<end_page>886</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26885.html</web_url>
			<author_list><author>
				<first_name>Happy</first_name>
				<middle_name>Elda</middle_name>
				<last_name>Murdiana</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>happy@ukrimuniversity.ac.id</email>
				<code>118026</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department Pharmacology, Faculty of Pharmacy, Universitas Kristen Immanuel, Yogyakarta, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Retno</first_name>
				<middle_name></middle_name>
				<last_name>Murwanti</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>retno_murwanti@ugm.ac.id</email>
				<code>118027</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>nanang</first_name>
				<middle_name></middle_name>
				<last_name>Fakhrudin</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nanangf@ugm.ac.id</email>
				<code>118028</code>
				<coreauthor>No</coreauthor>
				<affiliation>5Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hernawan</first_name>
				<middle_name></middle_name>
				<last_name>Hernawan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hern003@brin.go.id</email>
				<code>118029</code>
				<coreauthor>No</coreauthor>
				<affiliation>Research Center for Food Technology and Processing, National Research and Innovation Agency, Yogyakarta, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zullies</first_name>
				<middle_name></middle_name>
				<last_name>Ikawati</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zullies_ikawati@ugm.ac.id</email>
				<code>118030</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pharmacology and Clinical Pharmacy, Faculty Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Attenuation of diabetes linked testicular co-morbidity by Aloe vera: A dose-dependent transection study</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: The study demonstrated the management efficacy of Aloe vera leaf gel extract against diabetes induced testicular co-morbidity in rat.Materials and methods: Healthy and fertile rats were allowed for diabetes induction by streptozotocin injection at 40 mg dose/kg of somatic weight. Diabetic rats were treated for 28 days at 10, 20, 40 mg doses of hydro-ethanol (40:60, v/v) extract of Aloe vera gel or metformin at 2 mg/100 g of somatic weight as positive-control. On 29th day, rats were euthanized and sacrificed. The ameliorative effects were assessed covering glycemic, androgenic, spermatogenic, oxidative stress, histological, genomic and toxicity parameters following established methods. This recovery was compared against diabetic and positive-control groups.Results: Glucose-6-phosphate dehydrogenase, antioxidant and key androgenic enzyme activities, serum testosterone level and values of sperm parameters were diminished, confirming testicular co-morbidity in diabetes. Simultaneously, fasting blood sugar level, glucose-6-phosphatase activity, seminal vesicular fructose, testicular cholesterol, lipid peroxidation metabolite’s level and toxicity sensors were elevated in diabetic group. Significant amelioration (p˂0.05) in these parameters along with improved gene expression of testicular Δ5,3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase, Bax, and Bcl2 were observed in extract or metformin treated positive-control group, supported by histoarchitectures of testis, pancreas, and liver. The recovery percentages of the sperm parameters were 15-30% more in 20 mg, the maximum effective dose treated group than the positive-control group.  The phytocompounds were characterized by GC-MS study.Conclusion: Aloe vera extract may be used as an alternative to the gold standard anti-diabetic drug from the view point of cafeteria choice.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Aloe vera, Diabetes, Oxidative stress, Spermatogenesis, Male Infertility</keyword>
				<start_page>887</start_page>
				<end_page>901</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26911.html</web_url>
			<author_list><author>
				<first_name>Dibya</first_name>
				<middle_name></middle_name>
				<last_name>Pal</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dibyanutri.dp@gmail.com</email>
				<code>118151</code>
				<coreauthor>No</coreauthor>
				<affiliation>Bio-Medical Laboratory Science and Management, Vidyasagar University, Paschim Midnapore, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sukriti</first_name>
				<middle_name></middle_name>
				<last_name>Hazra</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sukritibabai1@gmail.com</email>
				<code>118152</code>
				<coreauthor>No</coreauthor>
				<affiliation>Bio-Medical Laboratory Science and Management, Vidyasagar Univesity, Paschim Midnapore, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Puja</first_name>
				<middle_name></middle_name>
				<last_name>Das</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>pujanutri13@gmail.com</email>
				<code>118153</code>
				<coreauthor>No</coreauthor>
				<affiliation>Centre for Life Sciences, Vidyasagar University, Midnapore 721102, West Bengal, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Debidas</first_name>
				<middle_name></middle_name>
				<last_name>Ghosh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>debidasghosh999@gmail.com</email>
				<code>118154</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Bio-Medical Laboratory Science and Management, Vidyasagar Univesity, Paschim Midnapore, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Evaluation of anti-gonadal activity of chloroform fraction of Thevetia peruviana leaves in male albino rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Anti-gonadal activity of chloroform fraction of Thevetia peruviana leaves (Ch-TPHmLE) in male rat was evaluated in this study.Materials and Methods: The Ch-TPHmLE (5 mg/100 g of body-weight (BW)/day) and standard antiandrogenic agent cyproterone acetate (CyPA) at the dose of 2.5 mg/100 g of BW were given to male rats for 28 days.  Sperm profile, serum gonadotrophins and testosterone were measured. Testicular superoxide-dismutase, catalase activities and zymographic-expression, malondialdehyde, conjugated-diene, TNF-α levels and immunohistochemical markers were evaluated. Testicular steroidogenic enzyme activities and androgen receptor (AR), StAR, HSD, Bcl2, P53, caspase-3 and BAX gene expressions were observed. LC-MS study was done for Ch-TPHmLE.Results: Sperm profile, gonadotrophins, testosterone as well as testicular steroidogenic key enzyme activities were reduced significantly (p&lt;0.05) and StAR, AR, HSD genes expressions were downregulated in Ch-TPHmLE and CyPA treated groups compared to the control group. Testicular anti-oxidant enzyme activities and zymographic-expression patterns were reduced significantly and malondialdehyde, conjugated-diene, TNF-α were increased significantly in the Ch-TPHmLE and CyPA treated groups. Testicular caspase-3 gene and proapoptotic genes P53, and BAX expressions were upregulated but anti-apoptotic gene Bcl2 was downregulated as confirmed by elevated number of apoptotic germ cells in immunostaining. The bio-active phyto-compounds γ-Sitosterol, Stigmasterol, Dehydroergosterol, β-Amyrin, Lupeol, and α-Amyrone were identified by LC-MS analysis of Ch-TPHmLE.Conclusion: It is concluded that the synergistic action of these phyto-molecule(s) of chloroform fraction of Thevetia peruviana (TPHmLE) shows anti-gonadal activity by alteration of serum gonadotrophins, and androgen levels and generation of excess oxidative free-radicals that trigger testicular germ-cell apoptosis.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Phyto molecules Sperm count Catalase 17&amp;beta, HSD Androgen receptor Anti, spermatogenic</keyword>
				<start_page>902</start_page>
				<end_page>918</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26923.html</web_url>
			<author_list><author>
				<first_name>Prabir</first_name>
				<middle_name></middle_name>
				<last_name>Mondal</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>prabir.mondal721127@gmail.com</email>
				<code>118201</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biomedical Laboratory Science and Management,
Vidyasagar University, Midnapore-721102,
West Bengal, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sayandev</first_name>
				<middle_name></middle_name>
				<last_name>Midya</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sayandevmidya1997@gmail.com</email>
				<code>118202</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biomedical Laboratory Science and Management,
Vidyasagar University, Midnapore-721102,
West Bengal, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Parag</first_name>
				<middle_name>Ranjita</middle_name>
				<last_name>Bera</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>paragranjitab@gmail.com</email>
				<code>118203</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biomedical Laboratory Science and Management,
Vidyasagar University, Midnapore-721102,
West Bengal, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Chhanda</first_name>
				<middle_name></middle_name>
				<last_name>Mallick Mukherjee</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>chhanda_nutri@mail.vidyasagar.ac.in</email>
				<code>118204</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Clinical Nutrition and Dietetics,
Department of Biomedical Laboratory Science and Management,
Vidyasagar University, Midnapore -721102,
West Bengal, India.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Comparing the effects of saffron and Mucosamin® spray on oral mucositis induced by radiotherapy: A randomized controlled clinical trial</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Mucositis is a common oral complication of the non-surgical therapy of cancer. Numerous studies have explored the pharmacological effects of saffron (Crocus sativus) in medicine. This study aimed to compare the effectiveness of saffron extract to Mucosamin® on relieving radiotherapy­induced oral mucositis.Materials and Methods: This randomized controlled clinical trial was conducted on head and neck cancer patients who received radiotherapy treatment at the oncology clinic of Shahid Beheshti Hospital in Qom. A total of 68 patients were divided into two groups of 34. In addition to standard treatment, the first group received six puffs of brewed saffron spray (100 mg) daily, and the second group received six puffs of Mucosamin® for 4 weeks. Repeated measures ANOVA, T-test, and Chi-square test were utilized to analyze pain intensity and mucositis grading. All data were analyzed using SPSS version 22.Results: The average pain intensity and mucositis grade decreased in both groups (a total of 61 patients). At baseline, the average pain intensity for the saffron and Mucosamin® groups was 6.29 ± 1.61 and 6.70 ± 1.93. By the end of the study, these figures dropped to 3.61 ± 1.35 and 4.00 ± 1.23. Likewise, the average mucositis grade in the two groups was 2.87 ± 0.34 and 2.56 ± 0.50 at the baseline, decreasing to 2.70 ± 0.46 and 2.40 ± 0.49 at the end of the study, respectively. There was no significant difference in the reduction of mucositis grade (p= 0.246) or pain intensity (p= 0.38) between the two groups.Conclusion: The brewed saffron spray showed effectiveness comparable to Mucosamin® spray in reducing pain intensity and grading oral mucositis.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Saffron, Head And Neck Cancer, Radiotherapy, artificial saliva, Oral mucositis</keyword>
				<start_page>919</start_page>
				<end_page>931</end_page>
				<web_url>https://ajp.mums.ac.ir/article_27350.html</web_url>
			<author_list><author>
				<first_name>Fatemeh Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Shafiee</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>fzshafiee98@gmail.com</email>
				<code>120111</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Dentistry, Qom University of Medical Sciences, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>elham</first_name>
				<middle_name></middle_name>
				<last_name>keykha</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dr.keykha@chmail.ir</email>
				<code>120112</code>
				<coreauthor>No</coreauthor>
				<affiliation>Research Center for Prevention of Oral and Dental Diseases, School of Dentistry, Baqiyatallah University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hoda</first_name>
				<middle_name></middle_name>
				<last_name>Abolhasani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hodaabolhasani@gmail.com</email>
				<code>120113</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, School of Medicine, Qom University of Medical Sciences, Qom, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>samira</first_name>
				<middle_name></middle_name>
				<last_name>hajisadeghi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dr.s.hajisadeghi@gmail.com</email>
				<code>120114</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Research Center for Prevention of Oral and Dental Diseases, School of Dentistry, Baqiyatallah University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Ameliorative effects of Spirulina on acute lead acetate toxicity complications in male rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Lead toxicity, a global health concern, damages many organs. Spirulina is a blue-green algae which has vitamins, minerals, and antioxidant properties, may alleviate injury resulting from lead toxicity. This investigation aimed to determine the protective benefits of Spirulina on acute lead toxicity.Materials and Methods: Thirty-two Wistar rats were divided into four groups of 8: Control, lead toxicity group which received lead acetate (50 mg/kg/day, i.p), EDTA group which received lead acetate + EDTA (Ethylenediaminetetraacetic acid, 50 mg/kg/day, i.p) and Spirulina group received lead acetate + Spirulina (1000 mg/kg/day, oral gavage). After one week, blood samples were taken for serum liver enzymes, testosterone, BUN (Blood Urea Nitrogen), and creatinine determination. Additionally, the livers, kidneys, and testes were dissected, weighed, and saved for evaluation of oxidant-antioxidant factors and histopathological studies. Antioxidant status was assessed by measuring the levels of malondialdehyde (MDA) and the activities of superoxide dismutase (SOD) and catalase in liver, kidney and testis homogenates.Results: Our results showed that lead toxicity caused a reduction in the organ index, which was improved by EDTA and Spirulina treatment. Lead toxicity significantly increased serum glutamic oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), alkaline phosphatase (AlkP), and creatinine, which were significantly reduced by Spirulina treatment. Histological studies indicated that treatment by EDTA and Spirulina improved histological changes in liver, kidney and testis organs. In addition, treatment with spirulina reduced MDA and increased SOD and catalase in liver and testis tissues.Conclusion: Spirulina improved complications of lead toxicity by improving redox balance. These promising results suggest its potential as a protective agent, though further studies are warranted to elucidate the precise mechanisms and clinical applicability.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Lead toxicity, Spirulina, Oxidative stress, Massive hepatic necrosis, Testis, Liver Function Tests</keyword>
				<start_page>932</start_page>
				<end_page>945</end_page>
				<web_url>https://ajp.mums.ac.ir/article_27148.html</web_url>
			<author_list><author>
				<first_name>Mohammad</first_name>
				<middle_name></middle_name>
				<last_name>Saroughi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mohammadsaroughi247@gmail.com</email>
				<code>119237</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad</first_name>
				<middle_name>Taghi</middle_name>
				<last_name>Khoshniat</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>khoshniatmt4011@mums.ac.ir</email>
				<code>119238</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Khatereh</first_name>
				<middle_name></middle_name>
				<last_name>Kharazmi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>khaterehkharazmi1400@gmail.com</email>
				<code>119239</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Seyedeh Elnaz</first_name>
				<middle_name></middle_name>
				<last_name>Nazari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nazarie4013@mums.ac.ir</email>
				<code>119240</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Milad</first_name>
				<middle_name></middle_name>
				<last_name>Bagheri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>miladbagheriofficial@gmail.com</email>
				<code>119241</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Majid</first_name>
				<middle_name></middle_name>
				<last_name>Khazaei</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>khazaeim@mums.ac.ir</email>
				<code>119242</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Hesperidin attenuates cisplatin-induced cardiotoxicity in rats through regulating autophagy</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Cisplatin is a well-known anticancer drug whose use has been limited due to a variety of side effects. Evidence has confirmed that cisplatin consumption is associated with cardiac toxicity. Unfortunately, no drug has yet been found to treat cardiac toxicity or reduce the side effects caused by cisplatin. However, hesperidin has been identified as an antioxidant agent which has protective effects on the heart tissue. This study explored the impact of hesperidin on cisplatin-induced cardiac toxicity through its antioxidant effect and adjustment of autophagy.Materials and Methods: It included male Wistar rats allocated into five groups: sham, cisplatin: animals treated with cisplatin (7.5 mg/kg, intraperitoneally) on the 4th day; and four groups which received hesperidin (50, 100, and 200 mg/kg, gavage, 1 week) along with cisplatin on the 4th day. A mixture of ketamine and xylazine was used to anesthetize all animals on day 8 to obtain blood and tissue samples and to record ECG.Results: The findings indicated that cisplatin led to an increase in creatine kinase-MB, lactate dehydrogenase, and malondialdehyde levels, and a reduction in total antioxidant capacity in heart tissue. Moreover, it reduced the expression of microtubule‑associated protein light chain (LC3-II) and beclin-1. ECG parameters included: Heart rate (HR) and QRS voltage complex which were reduced by cisplatin. However, hesperidin (100, and 200 mg/kg) reversed these changes.Conclusion: Hesperidin could protect cardiac tissue against cisplatin administration by exerting its antioxidant effect and regulating autophagy in a dose-dependent manner.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Cisplatin, Cardiac Toxicity, Hesperidin, Autophagy, Electrocardiogram</keyword>
				<start_page>946</start_page>
				<end_page>956</end_page>
				<web_url>https://ajp.mums.ac.ir/article_27360.html</web_url>
			<author_list><author>
				<first_name>Hoori</first_name>
				<middle_name></middle_name>
				<last_name>Heidari Kahkesh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>heydari.houri@gmail.com</email>
				<code>120159</code>
				<coreauthor>No</coreauthor>
				<affiliation>1Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2The Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, School of Medicine, Ahvaz Jundishapur</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Negin</first_name>
				<middle_name></middle_name>
				<last_name>Amini</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>negin.aminii@yahoo.com</email>
				<code>120160</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>1Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2The Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, School of Medicine, Ahvaz Jundishapur</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad</first_name>
				<middle_name></middle_name>
				<last_name>Badavi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>badavim@yahoo.com</email>
				<code>120161</code>
				<coreauthor>No</coreauthor>
				<affiliation>1Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2The Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, School of Medicine, Ahvaz Jundishapur</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mahin</first_name>
				<middle_name></middle_name>
				<last_name>Dianat</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dianatmah@yahoo.com</email>
				<code>120162</code>
				<coreauthor>No</coreauthor>
				<affiliation>1Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2The Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, School of Medicine, Ahvaz Jundishapur</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fereshteh</first_name>
				<middle_name></middle_name>
				<last_name>Nejaddehbashi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>fereshte_negad@yahoo.com</email>
				<code>120163</code>
				<coreauthor>No</coreauthor>
				<affiliation>Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Khojasteh</first_name>
				<middle_name></middle_name>
				<last_name>Hoseinynejad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>khoseinynegad@yahoo.com</email>
				<code>120164</code>
				<coreauthor>No</coreauthor>
				<affiliation>1Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2The Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, School of Medicine, Ahvaz Jundishapur</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Green synthesis of silver-coated zinc oxide nanocomposite using the walnut green husk extract and assessment of its cytotoxicity and antimicrobial activity against Streptococcus mutans</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: This study aimed to synthesize and characterize silver-coated zinc-oxide (ZnO/Ag) nanocomposite using green husk extract of Persian Walnut (Juglans regia L.) and evaluate its cytotoxicity and antimicrobial activity against Streptococcus mutans.Materials and Methods: In this in vitro experimental study, five groups were tested: hydroethanolic green husk extract (group A), green-synthesized ZnO/Ag nanocomposite using the extract (group B), chemically synthesized ZnO/Ag nanocomposite (group C), 0.2% chlorhexidine (positive control), and distilled water (negative control). Antibacterial activity against S. mutans was assessed via agar-well diffusion (inhibition zone diameters) and broth microdilution (MIC and MBC). Cytotoxicity was evaluated using the MTT assay. Tests were performed in triplicate across serial dilutions, with data analyzed by ANOVA.Results: Group A exhibited no inhibitory or bactericidal effect on S. mutans. Group B inhibited growth at 125 ppm, and group C at 31.25 ppm. Both groups B and C reduced S. mutans colony counts by approximately 3 logs (significant vs. group A) and showed minimal cytotoxicity.Conclusion: Both green-synthesized and chemically synthesized ZnO/Ag nanocomposites displayed lower antibacterial activity than chlorhexidine (CHX) against S. mutans, along with lower cytotoxicity, yet achieved a significant reduction in bacterial colony count.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Dental Caries, Streptococcus mutans, Zinc Oxide, Nanocomposites, Green synthesis, Green husk</keyword>
				<start_page>957</start_page>
				<end_page>971</end_page>
				<web_url>https://ajp.mums.ac.ir/article_27391.html</web_url>
			<author_list><author>
				<first_name>Hossein</first_name>
				<middle_name></middle_name>
				<last_name>Nematollahi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nematollahih@mums.ac.ir</email>
				<code>120324</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pediatric Dentistry, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Taraneh</first_name>
				<middle_name></middle_name>
				<last_name>Movahhed</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>movahhedt@mums.ac.ir</email>
				<code>120325</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pediatric Dentistry, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Majid</first_name>
				<middle_name></middle_name>
				<last_name>Darroudi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>darroudim@mums.ac.ir</email>
				<code>120326</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Modern Science and Technology, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hasan</first_name>
				<middle_name></middle_name>
				<last_name>Rakhshandeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rakhshandehh@mums.ac.ir</email>
				<code>120327</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hadi</first_name>
				<middle_name></middle_name>
				<last_name>Farsiani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>farsianih@mums.ac.ir</email>
				<code>120328</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Microbiology and Virology, Antimicrobial Resistance Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Alieh</first_name>
				<middle_name></middle_name>
				<last_name>Charmeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>charmeh.1370@gmail.com</email>
				<code>120329</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pediatric Dentistry, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Investigation of the effects of alcoholic frankincense extract on oxidative stress and inflammatory parameters in C57BL/6 mice with induced autoimmune encephalomyelitis</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Multiple sclerosis (MS) is a chronic autoimmune disease characterized by neuroinflammation and demyelination. Frankincense, a natural oleo-gum-resin obtained from the genus Boswellia (family Burseraceae), possesses anti-inflammatory and immunomodulatory properties. This study aimed to evaluate the therapeutic effects of alcoholic frankincense extract in an experimental model of MS.Materials and Methods: Female C57BL/6 mice were randomly assigned to three groups (n = 5). Experimental autoimmune encephalomyelitis (EAE) was induced by subcutaneous immunization with MOG₃₅–₅₅/CFA and intraperitoneal injection of pertussis toxin. Mice were treated orally with alcoholic frankincense extract (200 mg/kg) for 33 days. Serum levels of IL-17A, IL-23, transforming growth factor-β (TGF-β), and total antioxidant capacity (TAC) were measured, and brain tissues were examined histopathologically.Results: EAE induction caused significant weight loss, severe clinical symptoms, increased IL-17A and IL-23 levels, reduced TGF-β and TAC, and marked neuroinflammation with myelin damage. Frankincense treatment significantly improved clinical scores and body weight, decreased pro-inflammatory cytokines, enhanced antioxidant capacity, and attenuated inflammatory infiltration and myelin degradation in brain tissue.Conclusion: Alcoholic frankincense extract ameliorated EAE-associated inflammation and oxidative stress and exerted a protective effect on myelin integrity, suggesting its potential as a complementary therapeutic approach for MS. Further studies are warranted to confirm its clinical applicability.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis (EAE), Frankincense extract, Neuroinflammation, Inflammation</keyword>
				<start_page>972</start_page>
				<end_page>983</end_page>
				<web_url>https://ajp.mums.ac.ir/article_27390.html</web_url>
			<author_list><author>
				<first_name>Abdolghader</first_name>
				<middle_name></middle_name>
				<last_name>Tane</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ghadertane94@gmail.com</email>
				<code>120318</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yaser</first_name>
				<middle_name></middle_name>
				<last_name>Mohammadi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yaser7mohammadii@gmail.com</email>
				<code>120319</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, Iran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohsen</first_name>
				<middle_name></middle_name>
				<last_name>Naseri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>naseri_m2003@yahoo.com</email>
				<code>120322</code>
				<coreauthor>No</coreauthor>
				<affiliation>Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Gholamreza</first_name>
				<middle_name></middle_name>
				<last_name>Anani Sarab</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ghansa@yahoo.com</email>
				<code>120323</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Medical Immunology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hamidreza</first_name>
				<middle_name></middle_name>
				<last_name>Safari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>safari.h.r.1376@gmail.com</email>
				<code>120321</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Immunology, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Niloofar</first_name>
				<middle_name></middle_name>
				<last_name>Honari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>niloo.honari78@gmail.com</email>
				<code>120320</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>