<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Avicenna Journal of Phytomedicine</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ajp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2228-7930</journal_id_issn>
			<journal_id_issn_online>2228-7949</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<volume>16</volume>
			<number>4</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Oren-gedoku-to suppresses hypothalamic adenosine 5′-monophosphate-activated protein kinase activity and olanzapine-induced hyperglycemia</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Short communication</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Atypical antipsychotics such as olanzapine (OLZ) are associated with elevated blood glucose levels. Owing to serious cases of diabetic ketoacidosis and diabetic coma in Japan, OLZ is contraindicated in patients with diabetes, and blood glucose monitoring is advised even in non-diabetic cases. However, the precise mechanism of antipsychotic-induced hyperglycemia remains unclear; therefore, we investigated the role of hypothalamic adenosine 5′-monophosphate-activated protein kinase (AMPK) activity and adrenaline secretion in hyperglycemia induced by long-term OLZ administration. Additionally, we examined the potential effects of Oren-gedoku-to (OGT), a traditional Chinese medicine that suppresses hypothalamic AMPK activation, on hyperglycemia induced by chronic OLZ administration.Materials and Methods: Female Wistar rats were divided into three treatment groups: saline (control), OLZ (20 mg/kg/d), and OLZ (20 mg/kg/d)/OGT (500 mg/kg/d). Each treatment was orally administered twice daily for 2 weeks. Blood glucose and adrenaline concentrations, as well as hypothalamic AMPK alpha and phosphorylated AMPK alpha activities, were measured and compared using the Tukey–Kramer multiple comparison test.Results: Serum glucose and adrenaline levels were elevated in the OLZ group but not in the OLZ/OGT group. Furthermore, an increase in hypothalamic AMPK activity was observed in OLZ rats but not in OLZ/OGT rats.Conclusion: Our results suggest that OGT administration inhibits hyperglycemia induced by chronic OLZ administration by suppressing increased AMPK activity and adrenaline secretion.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Olanzapine, Hyperglycemia, Adrenaline, protein kinases, medicine, Chinese traditional</keyword>
				<start_page>590</start_page>
				<end_page>596</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26628.html</web_url>
			<author_list><author>
				<first_name>Yuna</first_name>
				<middle_name></middle_name>
				<last_name>Kusakabe</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yuna.ku.0915@gmail.com</email>
				<code>116891</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacokinetics and Pharmacodynamics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yasuyoshi</first_name>
				<middle_name></middle_name>
				<last_name>Ishiwata</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yasmpha@tmd.ac.jp</email>
				<code>116892</code>
				<coreauthor>No</coreauthor>
				<affiliation>bDepartment of Pharmacy, Tokyo Medical and Dental University Hospital, Tokyo Medical and Dental University (TMDU)</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Masashi</first_name>
				<middle_name></middle_name>
				<last_name>Nagata</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mna-mpha@tmd.ac.jp</email>
				<code>116893</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pharmacokinetics and Pharmacodynamics, 
Graduate School of Medical and Dental Sciences, 
Tokyo Medical and Dental University (TMDU)</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Effect of flaxseed oil supplementation on lipid profile in adults: A systematic review and dose-response meta-analysis of randomized controlled trials</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: This study evaluated the effects of flaxseed oil (FO, derived from Linum usitatissimum) supplementation on lipid profile parameters in adults.Materials and Methods: A systematic search was conducted across PubMed, Scopus, Google Scholar, and Web of Science up to February 2025, targeting randomized controlled trials (RCTs) that compared FO supplementation with a control group. A random-effects meta-analysis calculated lipid markers&#039; weighted mean difference (WMD) and 95% confidence interval (CI).Results: Thirty-six RCTs involving 1,959 participants were analyzed. FO supplementation significantly reduced triglyceride (TG) levels (WMD: -8.04 mg/dl; 95% CI: -15.63 to -0.45; p=0.038) but had no significant effect on total cholesterol (TC) (WMD: -1.15 mg/dl; 95% CI: -5.75 to 3.44; p=0.62), low-density lipoprotein-cholesterol (LDL-C) (WMD: 1.01 mg/dl; 95% CI: -1.35 to 3.41; p=0.41), or high-density lipoprotein cholesterol (HDL-C) (WMD: 0.1 mg/dl; 95% CI: -1.26 to 1.47; p=0.88). Subgroup analyses revealed greater TG and TC reductions in interventions &lt;12 weeks (TG: WMD: -16.86 mg/dl, p=0.005; TC: WMD: -3.5 mg/dL, p=0.03) and significant TG decreases in obese participants (WMD: -18.29 mg/dl, p=0.03). HDL-C increased significantly in individuals with baseline HDL-C ≤40 mg/dl (WMD: 1.35 mg/dl; 95% CI: 0.3 to 2.4; p=0.01). Non-linear dose-response analysis showed significant associations between FO dose and LDL-C (p=0.039) and alpha-linolenic acid intake with LDL-C (p=0.039) and TC (p=0.027).Conclusion: FO supplementation effectively lowers TG, especially in obese individuals and shorter interventions, and raises HDL-C in those with low baseline levels. While LDL-C and TC show minimal overall change, non-linear dose effects suggest that higher FO and α-Linolenic acid (ALA) doses may influence these markers, necessitating further research on optimal dosing.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Flaxseed oil Lipid profile Triglycerides LDL cholesterol HDL cholesterol Omega, 3 fatty acids</keyword>
				<start_page>597</start_page>
				<end_page>617</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26733.html</web_url>
			<author_list><author>
				<first_name>Maryam</first_name>
				<middle_name></middle_name>
				<last_name>Ahmadi-khorram</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>maryamahmadikhorram@gmail.com</email>
				<code>117346</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Alireza</first_name>
				<middle_name></middle_name>
				<last_name>Hatami</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hatami.alireza031@gmail.com</email>
				<code>117347</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Alireza</first_name>
				<middle_name></middle_name>
				<last_name>Takhttavous</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>alirezatakhttavoos@gmail.com</email>
				<code>117348</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohsen</first_name>
				<middle_name></middle_name>
				<last_name>Mohammadi-Sartang</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dr.mohamadi_nut@yahoo.com</email>
				<code>117349</code>
				<coreauthor>No</coreauthor>
				<affiliation>The Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Reza</first_name>
				<middle_name></middle_name>
				<last_name>Rahmanian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rahmanian3356@gmail.com</email>
				<code>117350</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sareh</first_name>
				<middle_name></middle_name>
				<last_name>Dashti</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sareh_dashti@yahoo.com</email>
				<code>117351</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Midwifery, Faculty of Nursing and Midwifery, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohsen</first_name>
				<middle_name></middle_name>
				<last_name>Nematy</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nematym@mums.ac.ir</email>
				<code>117352</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Nutrition</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>The efficacy of Hypericum perforatum L. for the treatment of premenstrual syndrome: A systematic review and meta-analysis</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Premenstrual syndrome (PMS) occurs in the luteal phase of the menstrual cycle and is characterized by physical, behavioral, and psychological symptoms.  Hypericum perforatum L. has shown promising therapeutic effects on this syndrome. This study aimed to systematically review the efficacy of H. perforatum on the treatment of PMS.Materials and Methods: Scopus, PubMed, Web of Science, Cochrane Library, and regional databases (e.g., Magiran, IranDoc, and SID) were searched for studies published from 2000 to September 10, 2023. The randomized controlled clinical trials were included, and the risk of bias was assessed using the Verhagen tool. Heterogeneity was evaluated using the Q test and I² statistics. The pooled standardized mean difference (SMD) with a 95% confidence interval was calculated using fixed-effect or random-effects models.Results: Nine randomized controlled trials involving 1,020 participants met the eligibility criteria and were included in the meta-analysis. H. perforatum was found to significantly reduce anxiety (SMD = -0.21, 95% CI: -0.37, -0.05), depression (SMD = -0.45, 95% CI: -0.74, -0.17), mood disturbances (SMD = -0.36, 95% CI: -0.66, -0.06) and behavioral symptoms (SMD = -0.43, 95% CI: -0.68, -0.19) compared to the placebo. Conclusion: The meta-analysis showed that H. perforatum is more effective than a placebo in alleviating the psychological symptoms of PMS. However, there is a lack of high-quality evidence for some outcomes, highlighting the need for further research. Future studies should also focus on identifying and characterizing the plant’s bioactive phytochemicals, which may lead to the development of novel, natural-based therapeutic agents.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Premenstrual syndrome Psychological symptoms Hypericum perforatum L Meta, Analysis</keyword>
				<start_page>618</start_page>
				<end_page>631</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26540.html</web_url>
			<author_list><author>
				<first_name>leila</first_name>
				<middle_name></middle_name>
				<last_name>bozorgian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>liela.bozorgian1@gmail.com</email>
				<code>116504</code>
				<coreauthor>No</coreauthor>
				<affiliation>PhD candidate in Midwifery, Midwifery Department, Student Research Committee, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>saeed</first_name>
				<middle_name></middle_name>
				<last_name>ghanbari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>saeedghanbari6.24@gmail.com</email>
				<code>116505</code>
				<coreauthor>No</coreauthor>
				<affiliation>Assistant professor, Department of Biostatistics and Epidemiology, School of
Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Javad</first_name>
				<middle_name></middle_name>
				<last_name>Mottaghipisheh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>imanmottaghipisheh@yahoo.com</email>
				<code>116506</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, SE, 75007, Uppsala, Sweden</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Maryam</first_name>
				<middle_name></middle_name>
				<last_name>Zahedian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mehregan.zahedian23@gmail.com</email>
				<code>116507</code>
				<coreauthor>No</coreauthor>
				<affiliation>Librarian, Nursing and Midwifery School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Parvin</first_name>
				<middle_name></middle_name>
				<last_name>Abedi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>parvinabedi@ymail.com</email>
				<code>116508</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Midwifery Department, Menopause Andropause Research Center, Ahvaz Jundishapur University of medical Sciences</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Solmaz</first_name>
				<middle_name></middle_name>
				<last_name>mohammadi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sl.mohammadi89@yahoo.com</email>
				<code>116509</code>
				<coreauthor>No</coreauthor>
				<affiliation>Assistant Professor, Midwifery Department, Reproductive Health Promotion Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Effect of pomegranate seed supplementation on cardiometabolic parameters: A systematic review and meta-analysis of interventional studies</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: This systematic review and meta-analysis of interventional studies aimed to investigate cardiometabolic protective effects of pomegranate (Punica granatum) seed supplementation in adults.Materials and Methods: PubMed, Embase, Scopus, and Web of Science ISI databases were systematically searched until February 2025. Pooled effect sizes were estimated using mean change and standard deviation (SD) of outcomes in each included trial and presented as standard mean differences (SMD) with a 95% confidence interval (95% CI). Also, heterogeneity among the included studies was measured using the I2 statistic.Results: Seven studies were included in the meta-analysis. Pomegranate seed supplementation led to a significant decrease in total cholesterol (TC) (SMD: -0.30; 95%CI, -0.55 to -0.05; p=0.01), triglycerides (TG) (SMD: -0.40; 95%CI, -0.65 to -0.15; p=0.002), Low-density lipoprotein to high-density lipoprotein ratio (LDL-C to HDL-C ratio) (SMD, -0.71; 95%CI, -1.12 to -0.30; p=0.001), and TG-HDL ratio (SMD, -0.49; 95%CI, -0.90 to -0.09; p=0.01) ratios, and tumor necrosis factor-alpha (TNF-a) levels (SMD: -0.94; 95%CI, -1.36 to -0.52; p&lt;0.001). However, no significant changes were observed in LDL-C, HDL-C, fasting blood sugar (FBG), insulin, hemoglobin A1C (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR), body mass index (BMI), and body weight.Conclusion: This meta-analysis revealed that pomegranate seed supplementation may have a beneficial effect on cardiometabolic health. However, given the limited number of included trials, the findings of this review should be interpreted with caution and are not yet generalizable to clinical practice. Therefore, it seems that more trials are needed to reach a firm conclusion.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Pomegranate Pomegranate seed Cardiometabolic risk factors Systematic review Meta, Analysis</keyword>
				<start_page>632</start_page>
				<end_page>654</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26771.html</web_url>
			<author_list><author>
				<first_name>Mostafa</first_name>
				<middle_name></middle_name>
				<last_name>shahraki jazinaki</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mostafashahrakijazinaki@gmail.com</email>
				<code>117526</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hossein</first_name>
				<middle_name></middle_name>
				<last_name>Bahari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>baharihossein3@gmail.com</email>
				<code>117527</code>
				<coreauthor>No</coreauthor>
				<affiliation>Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad Reza</first_name>
				<middle_name></middle_name>
				<last_name>Shadmand Foumani Moghadam</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mrsh13713@gmail.com</email>
				<code>117528</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran. Email: Mrsh13713@gmail.com.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad</first_name>
				<middle_name></middle_name>
				<last_name>Safarian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>safarianm@mums.ac.ir</email>
				<code>117529</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Rhizophora apiculata extracts improved memory function through inhibition of acetylcholinesterase and oxidative stress in scopolamine-induced memory deficits in rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: This study aims to investigate the neuroprotective, memory enhancement effects and phytochemical profile of Rhizophora apiculata.Materials and Methods: Ethanolic and aqueous extracts of R. apiculata leaves were prepared and screened for their antioxidant potential. In vitro studies were performed to assess the neuroprotective effects of R. apiculata extracts against scopolamine-induced neurotoxicity in SH-SY5Y cells. Further, in vivo, memory-enhancing effects of the extracts were evaluated in a scopolamine-induced amnesia model in rats by measuring brain acetylcholinesterase (AChE) levels, lipid peroxidation, and glutathione (GSH) activity. Furthermore, phytochemicals were identified through HR-LCMS analysis, and their binding interactions with the target protein AChE were investigated through in silico studies.Results: Treatment with ethanolic (100 µg/ml) and aqueous extracts (100 µg/ml) significantly reduced oxidative stress up to 89.386±2.37% in DPPH assay and 84.167±5.80% ABTS assays, respectively. The extracts (100 μg/ml) notably increased the viability (97.49%) of SH-SY5Y neuroblastoma cells against scopolamine-induced neurotoxicity. In vivo, studies revealed that both extracts improved memory function in scopolamine-induced amnesia by inhibiting the AChE activity and enhancing brain GSH levels while reducing lipid peroxidation. HR-LCMS analysis identified 54 distinct phytochemicals, with several compounds showing promising binding affinities like olitorin (-11.5 kcal) and gambiriin A3 (-10.7 kcal) for AChE in in-silico studies.Conclusion: Based on the findings of this study, R. apiculata leaves may be considered a promising source of neuroprotective compounds, with potential therapeutic applications for various neurological diseases.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Rhizophora apiculata, Antioxidant, Scopolamine, Memory enhancement, Anticholinesterase, Neuroprotection</keyword>
				<start_page>655</start_page>
				<end_page>670</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26582.html</web_url>
			<author_list><author>
				<first_name>Annie</first_name>
				<middle_name></middle_name>
				<last_name>Mande</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>anniemande@gmail.com</email>
				<code>116701</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Chemistry, KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India-522302|Department of Pharmacology, Bapatla College of Pharmacy, S.N.P. Agraharam, Bapatla, Andhra Pradesh, India - 522101.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Malothu</first_name>
				<middle_name></middle_name>
				<last_name>Narender</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>narendermalothu@gmail.com</email>
				<code>116700</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pharmaceutical Chemistry, KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India-522302</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Chakravarthi</first_name>
				<middle_name></middle_name>
				<last_name>Guntupalli</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>chakra_varthi123@kluniversity.in</email>
				<code>116702</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Chemistry, KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India-522302</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Kakarla</first_name>
				<middle_name></middle_name>
				<last_name>Ramakrishna</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>kakarlaramakrishna@kluniversity.in</email>
				<code>116703</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Chemistry, KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India-522302</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sathish Kumar</first_name>
				<middle_name></middle_name>
				<last_name>Konidala</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sathishkonidala@gmail.com</email>
				<code>116704</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmaceutical Sciences, School of Biotechnology and Pharmaceutical Sciences, Vignan's Foundation for Science Technology &amp; Research, Vadlamudi, Guntur (Dt.) Andhra Pradesh, India-522213.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Evaluation of the preventive effect of intravenous trans-sodium crocetinate followed by oral crocetin on contrast-induced nephropathy in patients with chronic kidney disease undergoing coronary angioplasty: A randomized placebo-controlled triple-blind clinical trial</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Contrast media (CM) can potentially cause nephropathy. Trans-sodium crocetinate (TSC) has shown promising antioxidant and anti-inflammatory properties in animal studies. This research sought to assess TSC efficacy in contrast-induced nephropathy (CIN) prevention.Materials and Methods: A randomized triple-blind trial involving 130 patients undergoing elective PCI (percutaneous coronary intervention) was conducted. Participants received either TSC (0.5 mg/kg) before the procedure, followed by crocetin tablets thrice daily for five days to evaluate its impact on CIN occurrence, or a placebo. The primary outcome was the occurrence of CIN, with secondary outcomes including blood urea nitrogen (BUN), serum creatinine (SCr), glomerular filtration rate (GFR), C-reactive protein (CRP), urine albumin-to-creatinine ratio (ACR), and prooxidant-antioxidant balance (PAB) test in a 5-day follow-up.Results: The study&#039;s primary outcome revealed a significantly lower CIN prevalence in the TSC group (7.7%) compared to the placebo group (24.6%) (p = 0.009). Secondary outcomes showing significant inter-group differences included BUN (p&lt;0.001), GFR (p&lt;0.05), CRP (p&lt;0.001), ACR (p&lt;0.05), and PAB test (p&lt;0.05). However, SCr and adverse effects did not differ significantly between the groups.Conclusion: TSC demonstrated its ability to impede nephrotoxic processes and significantly reduce CIN incidence. Additional clinical studies are required to further validate the beneficial effects in this context.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Saffron Trans sodium crocetinate Percutaneous coronary intervention Contrast, induced nephropathy</keyword>
				<start_page>671</start_page>
				<end_page>684</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26669.html</web_url>
			<author_list><author>
				<first_name>Sofia</first_name>
				<middle_name></middle_name>
				<last_name>Salari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>salaris971@mums.ac.ir</email>
				<code>117065</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>AmirHooshang</first_name>
				<middle_name></middle_name>
				<last_name>Mohammadpour</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mohamadpoorah@mums.ac.ir</email>
				<code>117066</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Arash</first_name>
				<middle_name></middle_name>
				<last_name>Gholoobi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>gholoobia@mums.ac.ir</email>
				<code>117067</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Vahid</first_name>
				<middle_name></middle_name>
				<last_name>Ghavami</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ghavamiv@mums.ac.ir</email>
				<code>117068</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biostatistics, Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Javad</first_name>
				<middle_name></middle_name>
				<last_name>Ramezani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ramezanij@mums.ac.ir</email>
				<code>117069</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ali</first_name>
				<middle_name></middle_name>
				<last_name>Eshraghi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>eshraghia@mums.ac.ir</email>
				<code>117070</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hossein</first_name>
				<middle_name></middle_name>
				<last_name>Hosseinzadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hosseinzadehh@mums.ac.ir</email>
				<code>117071</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Pharmacology</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Therapeutic effects of Asafoetida (Ferula foetida oleo-gum-resin) on lung function tests, clinical symptoms, and blood parameters in asthmatic patients</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Asthma is a common chronic disease with a wide global prevalence. In this disease, airway inflammation causes multiple attacks of wheezing. Treatment of asthma with chemical drugs has many complications. Therefore, researchers have recently focused on the use of medicinal plants for the treatment of asthma. So, the present study investigates the therapeutic effects of Asafoetida (Ferula foetida oleo-gum-resin) on asthma.Materials and Methods: The present study was done in two groups of stable severe asthmatic patients: one group was treated with Asafoetida (n=39, 300 mg capsules daily, oral) and the other with placebo (n=35, 300 mg capsules daily, oral) for one month. Respiratory symptoms, pulmonary function tests (PFT), Asthma control test (ACT) score, total and differential blood cell counts, and blood biochemical factors, were examined before and at the end of the 30-day treatment with asafoetida or placebo consumption.Results: The results indicated no statistically significant difference in the incidence of complications between the two groups. The mean ACT score in the both treated groups one month after initiation of the treatment was significantly increased compared to baseline (p&lt;0.001 for both cases). The percent change of ACT score was significantly higher in the asafoetida group compared to the placebo group (p&lt;0.05). Treatment with asafoetida also significantly improved wheezing (p&lt;0.001) and decreased forced vital capacity (FVC) (p&lt;0.001). Consumption of asafoetida did not affect serum lactate dehydrogenase (LDH) level or serum leukocyte level.Conclusion: According to these results, treatment with asafoetida improved respiratory symptoms and ACT score in patients with stable severe asthma. However, further clinical studies are needed to investigate the therapeutic potential of this plant in the treatment of asthma.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Asthma, Asafoetida, complication, Pulmonary function tests, Asthma control test (ACT) score, blood Cells, Wheezing</keyword>
				<start_page>685</start_page>
				<end_page>695</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26965.html</web_url>
			<author_list><author>
				<first_name>Vida</first_name>
				<middle_name></middle_name>
				<last_name>Hojati</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>vida.hojati@gmail.com</email>
				<code>118390</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>The effect of curcumin-piperine supplementation on liver transient elastography and biochemical indices in patients with non-alcoholic fatty liver disease: A randomized controlled trial</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Non-alcoholic fatty liver disease (NAFLD), characterized by an excessive buildup of triglycerides in hepatocytes, currently lacks an approved pharmacological treatment. This study investigated the therapeutic potential of a curcumin-piperine supplement, leveraging curcumin&#039;s established antioxidant, anti-inflammatory, anti-steatotic, and anti-fibrotic properties, with piperine enhancing its bioavailability. The objective was to assess its impact on cardiometabolic markers, liver function, and the progression of hepatic steatosis and fibrosis.Materials and Methods: Sixty NAFLD patients were enrolled in a randomized, 12-week, placebo-controlled study. Participants were randomly assigned to a treatment group receiving a daily oral supplement of 500 mg curcumin and 5 mg piperine, or a control group receiving a placebo. Measurements of anthropometrics, biochemical indices, and hepatic steatosis and fibrosis via FibroScan were taken at baseline and study end.Results: Anthropometric indices, and hepatic fibrosis decreased significantly within groups but not between groups for curcumin-piperine supplementation compared to placebo (p&lt;0.05). There were no significant differences between curcumin-piperine supplementation and placebo in total cholesterol, LDL-C (low-density lipoprotein, cholesterol), HDL-C (high-density lipoprotein, cholesterol), ALT (alanine transaminase), AST (aspartate transaminase), FBS (fasting blood sugar) and hepatic steatosis after 12 weeks.Conclusions: Curcumin-piperine supplementation showed no significant impact on hepatic or biochemical markers linked to NAFLD when compared to placebo, suggesting it may not be a beneficial adjunct therapy.Methods: Sixty patients diagnosed with non-alcoholic fatty liver disease (NAFLD) were enrolled in a randomized, 12-week, placebo-controlled study. Participants were randomly assigned to one of two groups: a treatment group receiving a daily oral supplement of 500 mg curcumin and 5 mg piperine, or a control group receiving a 505 mg microcrystalline cellulose placebo. Anthropometric measurements, biochemical indices, and assessments of hepatic steatosis and fibrosis via FibroScan were conducted at both baseline and at the conclusion of the 12-week intervention period.Results: Anthropometric indices (weight, BMI, waist circumference), and hepatic fibrosis decreased significantly within groups but not between groups for curcumin-piperine supplementation compared to placebo (p&lt;0.05).There were no significant differences between curcumin-piperine supplementation and placebo on total cholesterol, low density lipoprotein-C, high density lipoprotein-C, alanine aminotransferase, aspartate transaminase, fasting glucose and hepatic steatosis after 12 weeks. Conclusions: Compared to placebo, curcumin-piperine supplementation did not affect any of the hepatic or biochemical markers associated with NAFLD and would not appear to be an effective adjunct therapy.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Curcumin Fibrosis non, alcoholic fatty liver disease Piperine Steatosis</keyword>
				<start_page>696</start_page>
				<end_page>711</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26943.html</web_url>
			<author_list><author>
				<first_name>Sahar</first_name>
				<middle_name></middle_name>
				<last_name>Rafiee</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rafiee.nut@gmail.com</email>
				<code>118275</code>
				<coreauthor>No</coreauthor>
				<affiliation>Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan
University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad</first_name>
				<middle_name></middle_name>
				<last_name>Bagherniya</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>bagherniya@yahoo.com</email>
				<code>118276</code>
				<coreauthor>No</coreauthor>
				<affiliation>Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan
University of Medical Sciences, Isfahan, Iran
|Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ziba</first_name>
				<middle_name></middle_name>
				<last_name>Khoram</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dr.khorram99@gmail.com</email>
				<code>118277</code>
				<coreauthor>No</coreauthor>
				<affiliation>Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Amrollah</first_name>
				<middle_name></middle_name>
				<last_name>Ebrahimi Varzaneh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>a_ev11@yahoo.com</email>
				<code>118278</code>
				<coreauthor>No</coreauthor>
				<affiliation>Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Heidari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>heidari.biostat.64@gmail.com</email>
				<code>118279</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran|5
Isfahan Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Thozhukat</first_name>
				<middle_name></middle_name>
				<last_name>Sathyapalan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>thozhukat.sathyapalan@hyms.ac.uk</email>
				<code>118280</code>
				<coreauthor>No</coreauthor>
				<affiliation>Academic Diabetes, Endocrinology and Metabolism, Allam Diabetes Centre Hull Royal Infirmary Anlaby Road HU3 2JZ, Hull, UK</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Amir Hossein</first_name>
				<middle_name></middle_name>
				<last_name>Sahebkar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>amir_saheb2000@yahoo.com</email>
				<code>118281</code>
				<coreauthor>No</coreauthor>
				<affiliation>Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical
Sciences, Saveetha University, Chennai, India
|Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Gholamreza</first_name>
				<middle_name></middle_name>
				<last_name>Askari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>askari@mui.ac.ir</email>
				<code>118282</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan
University of Medical Sciences, Isfahan, Iran|Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Dorema aucheri extract for reducing oxidative stress and kidney injuries in diabetic rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Diabetic hyperglycemia causes oxidative stress, contributing to chronic kidney disease (CKD). This study evaluated the effects of ethanolic Dorema aucheri extract from aerial parts on oxidative stress, inflammation, and kidney injury in diabetic rats.Materials and Methods: Thirty male rats were randomly assigned to five groups (n=6): non-diabetic control, diabetic control, diabetic + metformin (500 mg/kg/day), and diabetic + D. aucheri extract (250 or 500 mg/kg/day). Treatments were given orally for 28 days. Serum and kidney samples were analyzed for fasting blood glucose (FBS), renal function [blood urea nitrogen (BUN), creatinine (Cr)], inflammatory cytokines [interleukin-6 (IL-6), interleukin-1β (IL-1β)], oxidative stress [malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)], mRNA expression [kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), B-cell lymphoma 2 (BCL-2), Caspase-9 (CASP-9)], stereology, and histopathology.Results: Treatment with D. aucheri hydroalcoholic extract significantly improved metabolic, inflammatory, oxidative, and renal outcomes in diabetic rats. Specifically, both 250 mg/kg and 500 mg/kg doses reduced blood glucose (p&lt;0.05), BUN (p&lt;0.05 and p&lt;0.01) and Cr (p&lt;0.01 for 500 mg/kg), IL-6 (p&lt;0.05), and IL-1β (p&lt;0.05 and p&lt;0.001), respectively. MDA decreased (p&lt;0.001 and p&lt;0.05), SOD, CAT, and GPx increased (p&lt;0.01). Renal KIM-1 and NGAL decreased (p&lt;0.01), CASP-9 decreased (p&lt;0.01 and p&lt;0.05), and BCL-2 increased (p&lt;0.05), respectively. Histopathology confirmed reduced kidney damage correlating with biochemical and gene expression improvements.Conclusion: Dorema aucheri extract has the potential to modulate antioxidant and apoptotic pathways and reduce kidney injury in diabetic rats. Further studies are needed to confirm its therapeutic efficacy.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Dorema aucheri, Oxidative stress, Antioxidant, Inflammation, Diabetes</keyword>
				<start_page>712</start_page>
				<end_page>726</end_page>
				<web_url>https://ajp.mums.ac.ir/article_27014.html</web_url>
			<author_list><author>
				<first_name>Alireza</first_name>
				<middle_name></middle_name>
				<last_name>Raeisi,</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>alirezaraeissi@gmail.com</email>
				<code>118589</code>
				<coreauthor>No</coreauthor>
				<affiliation>Endocrinology and Metabolism Research Center, Shiraz University of Medical Science, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Farhad</first_name>
				<middle_name></middle_name>
				<last_name>Koohpeyma</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>koohpeyma.f@sums.ac.ir</email>
				<code>118590</code>
				<coreauthor>No</coreauthor>
				<affiliation>Endocrinology and Metabolism Research Center, Shiraz University of Medical Science, Shiraz, Iran|Student research committee, Shiraz University of Medical Sciences, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Morvarid</first_name>
				<middle_name></middle_name>
				<last_name>Siri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>morvarid.siri@gmail.com</email>
				<code>118591</code>
				<coreauthor>No</coreauthor>
				<affiliation>Autophagy Research center, Shiraz University of Medical Sciences, Shiraz, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hediye</first_name>
				<middle_name></middle_name>
				<last_name>Fahandezh Saadi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hedie.f.sa@gmail.com</email>
				<code>118592</code>
				<coreauthor>No</coreauthor>
				<affiliation>Endocrinology and Metabolism Research Center, Shiraz University of Medical Science, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Forough</first_name>
				<middle_name></middle_name>
				<last_name>Saki</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sakeif@sums.ac.ir</email>
				<code>118593</code>
				<coreauthor>No</coreauthor>
				<affiliation>Endocrinology and Metabolism Research Center, Shiraz University of Medical Science, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Golrokh</first_name>
				<middle_name></middle_name>
				<last_name>Bahmani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>golrokhb53@gmail.com</email>
				<code>118594</code>
				<coreauthor>No</coreauthor>
				<affiliation>Endocrinology and Metabolism Research Center, Shiraz University of Medical Science, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Pardis</first_name>
				<middle_name></middle_name>
				<last_name>Negaresh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>pardisnegaresh@gmail.com</email>
				<code>118595</code>
				<coreauthor>No</coreauthor>
				<affiliation>Endocrinology and Metabolism Research Center, Shiraz University of Medical Science, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mesbah</first_name>
				<middle_name></middle_name>
				<last_name>Shams</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>shams@sums.ac.ir</email>
				<code>118596</code>
				<coreauthor>No</coreauthor>
				<affiliation>Endocrinology and Metabolism Research Center, Shiraz University of Medical Science, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sanaz</first_name>
				<middle_name></middle_name>
				<last_name>Dastghaib</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>suny.respina@gmail.com</email>
				<code>118588</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Endocrinology and Metabolism Research Center, Shiraz University of Medical Science, Shiraz, Iran|Autophagy Research center, Shiraz University of Medical Sciences, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>The antidiabetic effects of hesperidin and piperine in streptozotocin-induced diabetic rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Diabetes mellitus is a metabolic and chronic condition defined by increased blood glucose concentrations. The present research aimed to examine and compare the antidiabetic activity of hesperidin and piperine, alone and in combination, in rats with diabetes.Materials and Methods: In this research, streptozotocin (STZ, 60 mg/kg, intraperitoneally) was employed to cause type 2 diabetes in male rats. Following the induction of diabetes, the positive control group was treated with metformin (500 mg/kg), the normal control group was administered with normal saline, and the remaining groups received oral both compounds hesperidin and piperine (0.25 and 0.5 mg/kg), alone and in combination, for 4 weeks. Body weight alterations and several biochemical markers were evaluated.Results: The administration of metformin and two doses of hesperidin and piperine (0.25 and 0.5 mg/kg) significantly enhanced the body weight and reduced blood sugar, triglyceride (TG), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels compared to the diabetic control animals. Moreover, treatment with metformin and different doses of hesperidin and piperine decreased the serum levels of liver and kidney markers (hepatic enzymes) and diminished the adverse impacts on their activities.Conclusion: The findings of the current research indicate the potential of hesperidin and piperine for the management of diabetes and its associated health issues.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Hesperidin, Piperine, Diabetes Mellitus, Rat, Metformin</keyword>
				<start_page>727</start_page>
				<end_page>738</end_page>
				<web_url>https://ajp.mums.ac.ir/article_27035.html</web_url>
			<author_list><author>
				<first_name>Samira</first_name>
				<middle_name></middle_name>
				<last_name>Eghbali</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>eghbalis98@gmail.com</email>
				<code>118689</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pharmacognosy and Traditional Pharmacy, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>kiana</first_name>
				<middle_name></middle_name>
				<last_name>falahati</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>falahatikiana@gmail.com</email>
				<code>118690</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Shahnaz</first_name>
				<middle_name></middle_name>
				<last_name>Rajabi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sh.rajabi85@gmail.com</email>
				<code>118691</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Bita</first_name>
				<middle_name></middle_name>
				<last_name>Bijari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>bita.bijari@yahoo.com</email>
				<code>118692</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Social Medicine, Faculty of Medicine, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad</first_name>
				<middle_name></middle_name>
				<last_name>Malekaneh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>eghbalis@bums.ac.ir</email>
				<code>118693</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Biochemistry, School of Medicine Birjand University of Medical Sciences, Birjand, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Mistletoe extract (Iscador®) in cancer patients undergoing chemotherapy for prostate and bladder tumors: A prospective observational study</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: While mistletoe (a semi-parasitic evergreen plant) extract is commonly used as a complementary therapy in Europe, the evidence for its efficacy against the toxicity of chemotherapy is mixed. Our study aimed to evaluate the impact of mistletoe extract as a complementary therapy on the health-related quality of life (HRQoL) and hematological toxicities in patients with metastatic prostate and bladder cancers undergoing chemotherapy. Materials and Methods: This observational study prospectively involved patients with metastatic prostate and bladder cancers treated with either chemotherapy alone or in combination with Iscador®, a mistletoe extract. The study&#039;s primary outcome was HRQoL assessed at baseline and after each chemotherapy cycle. Secondary outcomes included hematological toxicities.Results: A total of 116 patients, including 59 with prostate cancer and 57 with bladder cancer, were enrolled. Analysis of the HRQoL symptom scales of prostate cancer patients revealed significant improvement in fatigue (p=0.014), pain (p=0.023), insomnia (p=0.017), and diarrhea (p=0.031) in the mistletoe extract group compared to the control group. In bladder cancer patients, no significant differences were observed in the HRQoL scales between the two treatment groups. Moreover, no significant differences were found between the mistletoe extract and control groups regarding hematological toxicities.Conclusion: Our study showed that mistletoe extract significantly improved four scales of HRQoL in prostate cancer patients undergoing chemotherapy. However, in patients with bladder cancer, the addition of mistletoe extract to chemotherapy does not appear to have a substantial impact on HRQoL, and thus, it should not be considered a complementary therapy for these patients.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Mistletoe extract Complementary therapy Health, related quality of life Prostate cancer Bladder cancer</keyword>
				<start_page>739</start_page>
				<end_page>750</end_page>
				<web_url>https://ajp.mums.ac.ir/article_27041.html</web_url>
			<author_list><author>
				<first_name>Somaye-Sadat</first_name>
				<middle_name></middle_name>
				<last_name>Heidari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>somayesadat_heidary@yahoo.com</email>
				<code>118715</code>
				<coreauthor>No</coreauthor>
				<affiliation>Chronic Kidney Disease Research Center, Research Institute for Urology and Nephrology, Shahid Beheshti
University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Roya</first_name>
				<middle_name></middle_name>
				<last_name>Ahmadi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>royaahmadi33334@gmail.com</email>
				<code>118716</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Maryam</first_name>
				<middle_name></middle_name>
				<last_name>Siavashpour</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>maryamsp28@gmail.com</email>
				<code>118717</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine, Iran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Anya</first_name>
				<middle_name></middle_name>
				<last_name>Jafari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>anyajafari@yahoo.com</email>
				<code>118718</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Radio-Oncology, Shohada-e Tajrish Medical Center, Shahid Beheshti University of Medical
Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Abbas</first_name>
				<middle_name></middle_name>
				<last_name>Basiri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>basiri_a@yahoo.com</email>
				<code>118719</code>
				<coreauthor>No</coreauthor>
				<affiliation>Urology and Nephrology Research Center, Research Institute for Urology and Nephrology, Shahid Beheshti
University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Abolfazl</first_name>
				<middle_name></middle_name>
				<last_name>Razzaghdoust</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>razzaghdoust@sbmu.ac.ir</email>
				<code>118720</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Urology and Nephrology Research Center, Research Institute for Urology and Nephrology, Shahid Beheshti
University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Bahram</first_name>
				<middle_name></middle_name>
				<last_name>Mofid</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mofid429@sbmu.ac.ir</email>
				<code>118721</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Radio-Oncology, Shohada-e Tajrish Medical Center, Shahid Beheshti University of Medical
Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>The hepatoprotective impacts of Citrullus colocynthis seeds extract on type 1 diabetes-induced liver inflammation and oxidative stress in rats: The role of nrf2/keap1 pathway</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Type 1 Diabetes (T1D) induces several consequences including hepatic damage resulting from oxidative stress and inflammation. The Nrf2/Keap1 pathway is crucial in oxidative stress signaling, and its modifications significantly influence health and illness. In this study, rats with T1D were used to test Citrullus colocynthis (CC) ability to reduce oxidative stress and inflammation in the diabetic liver.Materials and Methods: Twenty-one male Wistar rats were assessed. Three groups—control (healthy rats), diabetes (received STZ), and diabetes with drug—were allocated at random to the rats. The CC fruits extract was administered to diabetic rats via gavage for 40 days. Oxidative stress indicators, including malondialdehyde (MDA), total antioxidant capacity (TAC), and superoxide dismutase (SOD), were determined. The ELISA method quantified liver cytokines, whereas western blotting evaluated the Nrf2/Keap1 pathway. Results: The administration of CC in the Diabetes+Drug group dramatically reduced MDA levels while enhancing SOD activity and TAC levels in the liver. Following CC administration, Tumor necrosis factor alpha (TNF-α) levels decreased while rats with diabetes had higher amounts of interleukine-10 (IL-10) in their liver tissue. The CC administration could regulate the Nrf2/Keap1 pathway.Conclusion: This study concluded that a daily administration of 200 mg/kg CC for 40 days can enhance liver function in diabetic subjects by controlling the Nrf2/Keap1 pathway and reducing oxidative stress and inflammation.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Citrullus colocynthis, Type 1 diabetes, Nrf2/Keap1 pathway, Oxidative stress, Inflammation</keyword>
				<start_page>751</start_page>
				<end_page>761</end_page>
				<web_url>https://ajp.mums.ac.ir/article_27163.html</web_url>
			<author_list><author>
				<first_name>Fouzieh</first_name>
				<middle_name></middle_name>
				<last_name>Salimi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>salimif605@gmail.com</email>
				<code>119301</code>
				<coreauthor>No</coreauthor>
				<affiliation>Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Asie</first_name>
				<middle_name></middle_name>
				<last_name>Sadeghi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>asiesadeghi@gmail.com</email>
				<code>119302</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of clinical Biochemistry, school of Medicine, Kerman university of medical sciences, Kerman, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad Abbas</first_name>
				<middle_name></middle_name>
				<last_name>Bejeshk</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>m.bejeshk@yahoo.com</email>
				<code>119369</code>
				<coreauthor>No</coreauthor>
				<affiliation>Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
|Clinical Research Development Unit, Pastor Educational Hospital, Bam University of Medical Sciences, Bam, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad Amin</first_name>
				<middle_name></middle_name>
				<last_name>Rajizadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>aminrajizadeh@yahoo.com</email>
				<code>119300</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Physiology research center, Institute of neuropharmacology, Kerman university of medical sciences, Kerman, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Investigation of the co-administration of flaxseed supplementation with high-intensity interval training, resistance training, or combined training on hematological indices and kidney health in fructose/CCl4-induced NAFLD in rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Types of exercise training and flaxseed are beneficial approaches to improve non-alcoholic fatty liver disease (NAFLD)-induced hematological abnormalities. We aimed to determine which type of exercise training supplemented with flaxseed is more efficient for the improvement of blood and kidney function and hematological parameters in fructose/CCl4-induced NAFLD in rats.Materials and Methods: Forty male Wistar rats were divided randomly into five groups (n= 8): 1) ND (normal diet); 2) high-fat diet (HFD); 3) HFD + resistance training (RT) + Flaxseed; 4) HFD + high-intensity interval training (HIIT) + Flaxseed; and 5) HFD+ RT+ HIIT (CT) + Flaxseed. The interventions administered for 8 weeks once daily after NAFLD induction through CCl4 and fructose (15 weeks), and at the end of the 23rd weeks, hematological and renal indices were analyzed.Results: The blood and liver tissue indices indicated that the HFD group had high triglycerides (TG) and had significant steatosis, inflammation, and ballooning compared to the ND group. Red blood cell (RBC) count (p= 0.039), hemoglobin (Hb) (p= 0.011), and mean corpuscular hemoglobin concentration (MCHC) (p=0.001) in the HFD group were significantly lower, and mean corpuscular volume (MCV) (p=0.003) was higher compared to the ND group. RT+ flaxseed administration led to a decrease in RBC count and hematocrit (HCT) and increased MCH compared to the HFD group. These changes showed similar trends in the HIIT+ flaxseed group. All types of training along with flaxseed caused to decrease MCV (p&lt; 0.005) and elevated MCHC compared to HFD group (p=0.000). Renal markers analysis showed that CT+ flaxseed led to increased urea compared to the HIIT+ flaxseed group (p= 0.018), but there were no significant differences between other groups in urea or creatinine (Cr).Conclusion: Exercise training when supplemented with flaxseed can improve NAFLD-associated blood abnormalities, while HIIT was more efficient than other modes of training.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Flax, Exercise, Kidney, Hematology</keyword>
				<start_page>762</start_page>
				<end_page>775</end_page>
				<web_url>https://ajp.mums.ac.ir/article_27213.html</web_url>
			<author_list><author>
				<first_name>Abdorreza</first_name>
				<middle_name></middle_name>
				<last_name>Eghbal Moghanlou</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>abdorrezaeghbalmoghanlou@esenyurt.edu.tr</email>
				<code>119504</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Coaching Education, High School of Physical Education and Sports, Istanbul Esenyurt University, Istanbul, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Eslami</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>z.eslami@goums.ac.ir</email>
				<code>119506</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Biochemistry, Hamadan university of medical science, Hamadan, Iran
Department of Clinical Biochemistry, Golestan university of medical science, Golestan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Merve</first_name>
				<middle_name></middle_name>
				<last_name>UCA</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>merveuca@esenyurt.edu.tr</email>
				<code>119505</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Sports Management, High School of Physical Education and Sports, Istanbul Esenyurt University, Istanbul, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yusuf Can</first_name>
				<middle_name></middle_name>
				<last_name>Gürsoy</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yusuf.gursoy@dpu.edu.tr</email>
				<code>119507</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physical Education and Sports Teaching, Faculty of Sport Sciences, Kütahya Dumlupınar University, Kütahya, Turkey</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Seyed Javad</first_name>
				<middle_name></middle_name>
				<last_name>Mirghani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>seyedgavadmirghani@yahoo.com</email>
				<code>119509</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Shahid Mirghani Research Institute, Gorgan, Golestan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Beneficial effects of berberine and 6-gingerol against global cerebral ischemia: Insights from stereological, behavioral, and antioxidant enzyme activity</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Global cerebral ischemia (GCI) severely impacts brain function, leading to cognitive impairments and neuronal damage, particularly in the hippocampus. This study examined the neuroprotective and antioxidant properties of Berberine (BBR) and 6-Gingerol (GI), both separately and in combination, after inducing global cerebral ischemia (GCI) in Wistar rats.Materials and Methods: Fifty rats were randomly assigned to five groups: Sham, GCI, GCI+BBR, GCI+GI, and GCI+BBR+GI. Treatments were given intragastrically 15 min after inducing GCI. Short-term spatial memory was evaluated through the Y-maze test, and hippocampal structure and antioxidant enzyme activity were analyzed using stereological and biochemical methods, respectively.Results: GCI+BBR+GI showed better memory function (p&lt;0.01), antioxidant enzyme activities (p&lt;0.01), and stereological parameters than the other treatment groups.Conclusion: BBR, GI, and their combination improved memory, preserved CA1 pyramidal neurons, and enhanced antioxidant enzyme activities compared to GCI alone. The combined treatment produced the most pronounced protective effects. These findings suggest that BBR and GI, particularly together, effectively mitigate hippocampal damage and cognitive deficits following GCI.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Berberine 6, Gingerol Stroke Global cerebral ischemia Stereology</keyword>
				<start_page>776</start_page>
				<end_page>785</end_page>
				<web_url>https://ajp.mums.ac.ir/article_27255.html</web_url>
			<author_list><author>
				<first_name>Dariush</first_name>
				<middle_name></middle_name>
				<last_name>Mehboodi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dariush.meh@gmail.com</email>
				<code>119683</code>
				<coreauthor>No</coreauthor>
				<affiliation>Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Abbas</first_name>
				<middle_name></middle_name>
				<last_name>Shahedi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>abbasshahedi1355@gmail.com</email>
				<code>119684</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Anatomical Sciences, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad</first_name>
				<middle_name>Reza</middle_name>
				<last_name>Namavar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>namavarm@sums.ac.ir</email>
				<code>119685</code>
				<coreauthor>No</coreauthor>
				<affiliation>Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Clinic Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fatemeh</first_name>
				<middle_name></middle_name>
				<last_name>Rezaie</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nrezaie879@gmail.com</email>
				<code>119686</code>
				<coreauthor>No</coreauthor>
				<affiliation>School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Amirmohammad</first_name>
				<middle_name></middle_name>
				<last_name>Barzegari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>a.mohammad81@gmail.com</email>
				<code>119687</code>
				<coreauthor>No</coreauthor>
				<affiliation>۹۱. School of Public health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Effect of hydroalcoholic extracts of Quercus brantii and Salvia officinalis on the expression of wound healing and anti-inflammatory factors in human fibroblast cells</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Based on research regarding the regenerative properties of Quercus brantii in wound healing and the anti-inflammatory benefits of Salvia officinalis in promoting the wound healing process, this study aims to explore the wound healing and anti-inflammatory effects of hydroalcoholic extracts of Q. brantii and S. officinalis, alone or in combination, on human fibroblast cells.Materials and Methods: Hydroalcoholic extracts of Q. brantii and S. officinalis were prepared. Human fibroblast cell lines (HDF-1 cells) were treated with 1 to 256 µg/ml Q. brantii and/or S. officinalis extracts for 48 and 72 hr. Viability and migration potential of HDF-1 cells were  evaluated utilizing MTT colorimetric and wound healing methods, respectively. Additionally, IL-6 (Interleukin-6), TNF-α (Tomur Necrose Factor-α), and VEGF (Vascular endothelial growth factor ) levels were determined using ELISA kits and the expression of collagen I and III genes was estimated using real time PCR.Results: After 48 and 72 hr, Q. brantii extract (8 µg/ml) and/or S. officinalis extract (16 µg/ml) significantly increased cell proliferation and decreased the migration ability of HDF-1 cells (p≤0.05). Treatment with an optimum concentration of Q. brantii and S. officinalis extracts significantly decreased the TNF-α level in HDF-1 cells (p≤0.05). The individual extracts of Q. brantii and S. officinalis did not produce a statistically significant effect on the concentration of IL-6 protein. However, the combination of these extracts resulted in a significant reduction in IL-6 levels (p≤0.05). Both extracts also caused a significant decrease in VEGF concentration (p≤0.05) and significantly increased the expression of collagen I and III genes (p≤0.05).Conclusion: The combination of Q. brantii and S. officinalis extracts can accelerate the wound healing process by promoting fibroblast cell proliferation, reducing inflammation, and enhancing collagen I and III gene expression.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Quercus Brantii, Salvia officinalis, Wound healing, Fibroblast cells</keyword>
				<start_page>786</start_page>
				<end_page>797</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26672.html</web_url>
			<author_list><author>
				<first_name>Vahid</first_name>
				<middle_name></middle_name>
				<last_name>Hasanvand</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>vahidhasanvand4363@gmail.com</email>
				<code>117081</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biology, Faculty of Sciences, Shahid Chamran Unversity of Ahvaz, Ahvaz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mahnaz</first_name>
				<middle_name></middle_name>
				<last_name>Kestami</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>m.kesmati@scu.ac.ir</email>
				<code>117082</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biology, Faculty of Sciences, Shahid Chamran Unversity of Ahvaz, Ahvaz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Elham</first_name>
				<middle_name></middle_name>
				<last_name>Hoveizi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>elham.hoveizi@gmail.com</email>
				<code>117083</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biology, Faculty of Sciences, Shahid Chamran Unversity of Ahvaz, Ahvaz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hossein</first_name>
				<middle_name></middle_name>
				<last_name>Zhaleh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hossain_jale@yahoo.com</email>
				<code>117080</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Biology, Faculty of Sciences, Bu-Ali Sina Unversity, Hamedn, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>