Avicenna Journal of Phytomedicine

en Almond for mild to moderate Alzheimer’s disease: A randomized clinical trial Short communication Alzheimer’s disease, Dementia, Almond, Persian Medicine, Herbal Medicine 195 206 https://ajp.mums.ac.ir/article_26297.html Mohsen Mohajeri mo_mohajeri@yahoo.com 115441 No Department of Traditional Medicine, Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Traditional Medicine, School Fataneh Hashem-Dabaghian dabaghian.f@iums.ac.ir 115442 No Department of Traditional Medicine, Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran. Shima Raeesi shraeesi@sina.tums.ac.ir 115443 No Department of Geriatric Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran Somaye Mahroozade dr.mahroozade@gmail.com 115444 Yes Department of Traditional Medicine, Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran

en Antioxidant, anti-inflammatory and cytoprotective effects of crocin, a bioactive constituent of saffron, in Alzheimer’s and Parkinson’s diseases with a focus on molecular mechanisms: A systematic review Review Article Crocin Alzheimer’s disease Parkinson’s disease antioxidant anti, inflammatory cytoprotective 207 228 https://ajp.mums.ac.ir/article_26032.html Zahra Tayarani-Najaran tayaraninz@mums.ac.ir 114283 No Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran |Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran Elham Hadipour hadipour_e@guilan.ac.ir 114284 No Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran Shirin Ramazani shirinramezani18@gmail.com 114285 No Healthcare center, Shirvan Health and Treatment Network, North Khorasan University of Medical Sciences, Bojnord, Iran Leyli Taghizadeh leylitaghizadeh085@gmail.com 114286 No Imam Khomeini Hospital, Shirvan Health and Treatment Network, North Khorasan University of Medical Sciences, Bojnord, Iran Elham Ramazani el.ramazani@yazd.ac.ir 114287 Yes Department of Biology, Yazd University, Yazd, Iran

en Possible therapeutic effects of Plantago major in women with high menstrual bleeding: A systematic review of randomized clinical trials Review Article Plantago, Bleeding, Menorrhagia, Heavy menstrual bleeding, Women's health 229 241 https://ajp.mums.ac.ir/article_26360.html Mohammad Reza Khazdair m.khazdair@yahoo.com 115706 Yes Birjand University of Medical Sciences , Ghafari Street, Birjand, South Khorasan, Iran. Tel: +985632395696 Fax: +985631635801 Majid Kianmehr majid.kianmehr@gmail.com 115707 No Esfarayen Faculty of Medical Sciences, Esfarayen, Iran

en Impact of flavonoid-rich herbal medicines on idiopathic heavy menstrual bleeding: A systematic review and meta-analysis of randomized controlled trials Review Article Menorrhagia Idiopathic heavy menstrual bleeding Persian medicine Herbal Medicines Meta, Analysis Systematic review 242 259 https://ajp.mums.ac.ir/article_26057.html Marzieh Qaraaty gharaaty1387@yahoo.com 114408 No Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ayesheh Enayati enayati_phyto@yahoo.com 114409 No Ischemic research Center, Golestan University of Medical Sciences, Gorgan, Iran maedeh rezghi maedehrezghi@yahoo.com 114411 No Traditional Medicine and History of Medical Sciences Research Center, Health, Research Institute, Babol University of Medical Sciences, Babol, Iran Department of Persian Medicine, School of Persian Medicine, Babol University of Medical Abdolhalim Rajabi rajabiepid@gmail.com 114412 No Health Management and Social Development Research Center, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran Mojgan Tansaz tansaz_mojgan@yahoo.com 114413 No Departmant of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Masoud Mohammadi mohammadi@goums.ac.ir 114414 No Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran. Amirhossein Sahebkar sahebkara@mums.ac.ir 114410 Yes Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

en Nordihydroguaiaretic acid attenuates TNFα-dependent intercellular adhesion molecule-1 expression in cultured human umbilical vein endothelial cells via targeting TNFα-PI3K-NF-κB-ICAM1 pathway Original Research Article Human umbilical vein endothelial cells (HUVECs) TNFα Intercellular adhesion molecule, 1 (ICAM1) NDGA PI3K NF, κB 260 271 https://ajp.mums.ac.ir/article_26225.html Tapan Kumar Mukherjee tapan400@gmail.com 115129 Yes Amity Institute of Biotechnology, Amity University, Major Arterial Road, Action Area II-36, 37, 38, Rajarhat, New Town, Kolkata 700156, West Bengal, India. Parth Malik parthmalik1986@gmail.com 115130 No Swarrnim Startup and Innovation University, Bhoyan-Rathod, Gandhinagar, Gujarat Raj Singh dr.rajsingh09@gmail.com 115131 No Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India. Vishal Patel vishalpatel2003@yahoo.co.in 115132 No Institute of Biotechnology, Amity University, Noida 201301, Uttar Pradesh, India Raman Kumar ramankumar4@gmail.com 115133 No Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India.

en Wortmannin exhibits anticancer activity in oral cancer cell line by targeting PI3K, AKT and mTOR pathway Original Research Article Oral cancer Wortmannin In, silico analysis PI3K/AKT Apoptosis Cell cycle 272 292 https://ajp.mums.ac.ir/article_26226.html GAURI M. KUMBHAR gaurikumbhar764@gmail.com 115135 No Department of Oral Pathology. Dr. D. Y. Patil Dental College and Hospital. Dr. D. Y. Patil Vidyapeeth, (Deemed to Be University). Sant Tukaram Nagar, Pimpri, Pune. India. Poonam Suryawanshi poonam.suryawanshi@dpu.edu.in 115136 No Central Research Facility. Dr. D. Y. Patil Medical College, Hospital and Research Centre. Dr. D. Y. Patil Vidyapeeth, (Deemed to Be University). Sant Tukaram Nagar, Pimpri, Pune. India. VAIBHAV SUNIL LADKE drvaibhavladke@gmail.com 115137 Yes Tissue Culture & Cell Biology Lab. Central Research Facility. Dr. D. Y. Patil Medical College, Hospital and Research Centre. Dr. D. Y. Patil Vidyapeeth, (Deemed to Be University). Sant Tukaram Nagar, Pimpri, Pune. India. 411018

en Suppressive effect of lemon (Citrus limon L. Burm. f.) extract toward pro-tumor immune response in DMBA-induced carcinogenesis mouse Original Research Article Adaptive immunity, Cancer, Citrus limon, Immunomodulatory, Innate immunity 293 304 https://ajp.mums.ac.ir/article_26348.html Wira Eka Putra wep.cendekia@gmail.com 115663 Yes Biotechnology Study Program, Department of Applied Sciences, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, East Java, Indonesia. Chalissa Nuruzzulfa 117170 Yes Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, East Java, Indonesia Dea Esaayu Mahabella 117171 Yes Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, East Java, Indonesia Ramdhani Faradilla Intania Nuraıda 117172 Yes Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, East Java, Indonesia Arief Hıdayatullah 117173 Yes Democratic Governance and Poverty Reduction Unit, United Nations Development Programme, Eijkman-RSCM Building, Jakarta, Indonesia. Muhaimin Rifa’i 117174 Yes Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, East Java, Indonesia

en The modulatory role of 6-gingerol-rich portion of ginger on brain oxidative stress, inflammation and neurotransmission in chronic unpredicted mild stress-induced depressed male Wistar rats Original Research Article Behavioral Antioxidant Anti, inflammatory Biochemical Neurotransmission 305 317 https://ajp.mums.ac.ir/article_26364.html Maryam Tayo Ayinla gazmark@unilorin.edu.ng 115715 No Department of Physiology, University of Ilorin, Ilorin, Nigeria Abraham Olufemi Asuku asufem2017@gmail.com 115716 Yes Flamingo street Stadium road

en Evaluation of the monotherapy effect of crocin on mild-to-moderate diabetic retinopathy: A randomized clinical trial Original Research Article Crocin, Diabetic retinopathy, Best corrected visual acuity Macular thickness, Retinal thickness 318 329 https://ajp.mums.ac.ir/article_26305.html Sayed Ahmad Mohajeri mohajeria@mums.ac.ir 115470 Yes Department of Pharmacodynamics and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran

en Comparison of Hibiscus sabdariffa L. extract and hydrochlorothiazide as adjuncts to Valsartan in managing hypertension in type 2 diabetic nephropathy: A randomized clinical trial Original Research Article Hibiscus sabdariffa L, Diabetes Mellitus, Molecular docking 330 341 https://ajp.mums.ac.ir/article_26575.html Hassan Mirzaei hmirzaei@goums.ac.ir 116674 Yes Golestan University of Medical Sciences Ayesheh Enayati enayati_phyto@yahoo.com 116675 No Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran Maryam Kiani kiani.m94@gmail.com 116676 No 1Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran Somayeh Ghorbani s.ghorbani.gh@gmail.com 116677 No 1Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran Gokhan Zengin gokhanzengin@selcuk.edu.tr 116678 No Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran Saeid Amirkhanlou drsam74ir@ymail.com 116679 No Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran

en Evaluation of nano-curcumin oral formulation efficacy in prevention of chemotherapy-induced adverse reactions in metastatic colorectal cancer patients Original Research Article Metastatic colorectal cancer Nanocurcumin, Chemotherapy toxicity, Cancer progression, FOLFOX/XELOX±Bevacizumab 342 355 https://ajp.mums.ac.ir/article_26317.html Mahdi Jannati Yazadan Abad jannatim901@gmail.com 115519 No Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Abolghasem Allahyari allahyaria@mums.ac.ir 115520 No Department of Hematology-Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mostafa Kamandi kamandim@mums.ac.ir 115521 No Department of Hematology-Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Omid Arasteh arasteho@mums.ac.ir 115522 No Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Mehdi Varmaghani mehdivarmaghani@gmail.com 115523 No Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Management Sciences and Health Economics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran. Hedyieh Karbasforooshan hedyiehk72@gmail.com 115524 No Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Mahmoud Reza Jaafari jafarimr@mums.ac.ir 115525 No Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Hamidreza Kheradmand hamidreza.kheradmand@gmail.com 115526 No Mashhad University of Medical Sciences, School of Medicine, Mashhad, Iran Abolfazl Eftekhari ablfzl1993@gmail.com 115527 No Babol University of Medical Sciences, School of Medicine, Babol, Iran Sepideh Elyasi elyasis@mums.ac.ir 115528 Yes Pharmacotherapy

en Vitex agnus-castus extract improved the endocrine profile and important gene expression in rat ovaries with polycystic ovary syndrome Original Research Article AMH PCOS P450arom CTRP6 Vitex agnus, castus 356 366 https://ajp.mums.ac.ir/article_26622.html Mahtab Abbaszadeh mahtababaszadeh4791@gmail.com 116872 No Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz Gholamali Jelodar jelodar@shirazu.ac.ir 116873 Yes Shiraz University Saeed Hossainzadeh hosseinzadeh@shirazu.ac.ir 116874 No Department Food hygiene, School of Veterinary Medicine, Shiraz University, Shiraz Azam Salmani shymas042@gmail.com 116875 No Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz

en Dexamethasone-induced hepatic biochemical and pathological damages are attenuated by Cynodon dactylon extract containing hexadecanoic acid via reduction of glucose uptake: In vitro and in vivo studies Original Research Article Dexamethasone, Hepatic injuries, Hypolipidemic effect, glucose uptake 367 385 https://ajp.mums.ac.ir/article_26623.html Sadaf Mottaghian sadafy.m.97@gmail.com 116876 No Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran Ayshin Khalilarya ayshinkhalilarya@gmail.com 116877 No Experimental & Applied Pharmaceutical Sciences Research Center, Urmia University of Medical Sciences, Urmia, Iran Hassan Malekinejad hassanmalekinejad@yahoo.com 116878 Yes a Experimental & Applied Pharmaceutical Sciences Research Center, Urmia University of Medical Sciences, Urmia, Iran; b Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran

en Protective effect of pomegranate seed oil against lead acetate-induced toxicity on the hippocampus and bone marrow in rats Original Research Article Pomegranate seed oil, Lead acetate, Oxidative stress, Hippocampus, bone marrow 386 397 https://ajp.mums.ac.ir/article_26495.html Mohaddeseh Sadat Alavi alavimhd@mums.ac.ir 116311 No Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran azar Hosseini hoseiniaz@mums.ac.ir 116312 No Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran Fereshte Torabi torabif991@mums.ac.ir 116313 No Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mitra Rayati banadkooki raeiatibm971@mums.ac.ir 116314 No Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Zahra Taghadosi taghadosiz971@mums.ac.ir 116315 No Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Taher Boroushaki boroushakimt@mums.ac.ir 116316 Yes Pharmacology