<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Avicenna Journal of Phytomedicine</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ajp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2228-7930</journal_id_issn>
			<journal_id_issn_online>2228-7949</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2025</year>
				<month>1</month>
				<day>1</day>
			</pubdate>
			<volume>15</volume>
			<number>1</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Anti-cancer effects of frankincense methanolic extract on brain metastatic breast cancer cells</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Short communication</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Brain metastasis in patients with breast cancer is considered a deadly event. The oleogum resins of Boswellia species, known as Frankincense  has been found to have anti-cancer properties in many studies. The main purpose of our research was to evaluate these effects on brain metastatic cancer cells.Materials and Methods: Primary (4T1T) and brain metastatic (4T1B) tumor cells were isolated from breast cancerous mice. Cytotoxic, apoptotic, and anti-metastatic effects of the methanolic extract of frankincense were evaluated with MTT assay, propidium iodide (PI) flow cytometric assay, and scratch test, respectively. Zymography assay was used to evaluate the effects of extract on the matrix metalloproteinases-2 and -9 (MMP-2 /9) expression/activity.Results: The methanolic extract of frankincense has significant cytotoxic and apoptotic effects on 4T1B cells (p&lt;0.001). Interestingly, 4T1B cells are more prone to these effects than 4T1T cells. In 4T1B, the anti-metastatic effects of frankincense extract were confirmed. Frankincense suppressed MMP-2/9 protein expression both in 4T1T and 4T1B.Conclusion: Our findings indicated that frankincense extract has a potent cytotoxic effect on brain metastatic tumor cells and induces apoptosis in these cells. Unlike many anti-cancer drugs which have very little ability to combat and kill brain metastatic cancer cells, frankincense extract can be considered a suitable candidate to fight these cells.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Frankincense, Brain metastasis, Triple negative breast cancer, Antimetastatic</keyword>
				<start_page>776</start_page>
				<end_page>783</end_page>
				<web_url>https://ajp.mums.ac.ir/article_24655.html</web_url>
			<author_list><author>
				<first_name>Mohammad</first_name>
				<middle_name></middle_name>
				<last_name>Kamalabadi-Farahani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>kamalabadi@shmu.ac.ir</email>
				<code>108091</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fatemeh</first_name>
				<middle_name></middle_name>
				<last_name>Jamshidi Adegani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>fatemeh@unizwa.edu.om</email>
				<code>108092</code>
				<coreauthor>No</coreauthor>
				<affiliation>Laboratory for Stem Cell &amp; Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, P. O. Box: 33, PC 616, Oman</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Roqaye</first_name>
				<middle_name></middle_name>
				<last_name>Karimi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>roghaye.karimi@modares.ac.ir</email>
				<code>108093</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Hematology and Cell Therapy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Amir</first_name>
				<middle_name></middle_name>
				<last_name>Atashi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>atashia@gmail.com</email>
				<code>108094</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>The effect of Valeriana officinalis tea on sympathovagal tone and cardiac function in healthy volunteers: A semi-experimental study</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Short communication</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: The use of herbal teas can affect some physiological parameters of the body. Valerian has been used as a valuable medicinal plant. There are reports about sedative and sleep-inducing effects of Valeriana officinalis L. (VOT) on the nervous system. But in relation to its possible effect on the autonomic nervous system, the available information is limited. This study aimed to determine the effect of VOT on sympathovagal tone based on heart rate variability indices.Materials and Methods: In this semi-experimental study, 12 healthy volunteers were enrolled. At first, the participants received 50 ml of water as the control group, and then after the clearance time, they received VOT with a dilution of 50% with the same temperature and volume and were considered the intervention group. Assessment of sympathovagal tone was performed in terms of heart rate variability indices. There were 5 recording steps: baseline, after drinking water, and 5, 20, and 30 minutes after drinking VOT.Results: The mean±SD of the average heart rate per minute at the five recording steps after VOT was 65.4±15.5, 63.5 ±14.6, 62.7±15.6, 61.8±16.09, and 60.9 15.2, respectively (p &lt;0.05). The average arterial systolic pressure at the five recording steps after VOT was 119.4±7.4, 117.9± 9, 114.3±7.9, 113.8±8.6, and 114±6.5 mmHg, respectively.Conclusion: A single cup of VOT significantly decreased the heart rate. This effect may be associated with a decrease in sympathetic activity and an increase in parasympathetic activity.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Valeriana Officinalis, Heart rate, blood pressure, Sympathovagal, Electrocardiogram</keyword>
				<start_page>784</start_page>
				<end_page>793</end_page>
				<web_url>https://ajp.mums.ac.ir/article_24974.html</web_url>
			<author_list><author>
				<first_name>Seyed.Mehran</first_name>
				<middle_name></middle_name>
				<last_name>Hosseini</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hosseini@goums.ac.ir</email>
				<code>109509</code>
				<coreauthor>No</coreauthor>
				<affiliation>Neuroscience Research Center, Department of Physiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Shahab</first_name>
				<middle_name></middle_name>
				<last_name>Zanganeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>shahabzang1375@gmail.com</email>
				<code>109510</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Marzieh</first_name>
				<middle_name></middle_name>
				<last_name>Qaraaty</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dr.qaraati@goums.ac.ir</email>
				<code>109508</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences,</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Topical application of medicinal plant oils in pediatric-related disorders: A comparative review article based on traditional Persian medicine</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Review Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Researchers have considered medicinal oils to prevent and treat pediatric diseases. In the traditional Persian medicine (TPM) doctrine, anointment is widely used in order to avoid and treat diseases. This study aimed to evaluate and reconcile the uses of anointment in children in TPM and the new studies.Materials and Methods: Accordingly, TPM documents were scrutinized for anointments and their applications in pediatric disorders. Moreover, new studies were reviewed in Google scholar, PubMed, Medline, Scopus, and Web of Science until June 2022.Results: In the health preservation field, TPM scholars have recommended daily anointment with some oils like sweet almonds in the early months after birth to improve growth, strengthen the body, and prevent dry skin, and new studies have confirmed the effectiveness of some oils accordingly. In the treatment field, various oils are recommended, namely sweet almond oil for weight disorders, violet oil for insomnia, olive oil and chamomile oil for functional constipation, infantile colic and enuresis, and olive oil for diaper rash and atopic dermatitis and new studies have shown their effectiveness. Sweet almond, chamomile, violet, olive, and rose oils are among the most widely used oils in Persian medicine for children, which we have discussed in this study.Conclusion: Due to the non-invasive nature of anointment and the observation of minimal adverse effects in studies, it can be given attention for maintaining pediatric health and treating their diseases.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Anointment, Traditional Medicine, Persian medicinal oil, pediatric diseases</keyword>
				<start_page>794</start_page>
				<end_page>815</end_page>
				<web_url>https://ajp.mums.ac.ir/article_24303.html</web_url>
			<author_list><author>
				<first_name>Maryam</first_name>
				<middle_name></middle_name>
				<last_name>Mohammadian-Dameski</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mohammadianm943@mums.ac.ir</email>
				<code>106565</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>AhmdShah</first_name>
				<middle_name></middle_name>
				<last_name>Farhat</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>farhata@mums.ac.ir</email>
				<code>106566</code>
				<coreauthor>No</coreauthor>
				<affiliation>Neonatal Research Center, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Maliheh</first_name>
				<middle_name></middle_name>
				<last_name>Motevasselian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>motavasselianm@mums.ac.ir</email>
				<code>106567</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Vahid Reza</first_name>
				<middle_name></middle_name>
				<last_name>Askari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>askariv941@mums.ac.ir</email>
				<code>106568</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Fertility-enhancing effects of Prunus amygdalas oil on reproductive functions of male rats: A two-generation study</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Prunus amygdalas (Almond; PA) has extensively been used in traditional medicine and has been the source of robust phenolic compounds. The current study intended to evaluate the fertility-enhancing effect of PA on male rats infertility and reproductive performance of two successive generations of rats namely, F0 and F1.Materials and Methods: Chemical composition of the oil was established with the aid of Gas Chromatography-Mass Spectrometry (GC-MS). The oil was then subjected to in-vitro antioxidant assay via DPPH (1,1-diphenyl-2-picrylhydrazyl) and ROS (reactive oxygen species), followed by in vivo toxicity testing. In the fertility assessment, 1 and 2 ml/kg of PA oil was given to rats up to pre-cohabitation, cohabitation, gestation and lactation period. The reproductive performance along with hormonal and antioxidant markers of F1 generationwas estimated and histopathological evaluation of both sex organs was done. Further, ethanol-induced male infertility model was established and sex hormones, antioxidant markers (superoxide dismutase (SOD), Glutathione peroxidase (GPx) and lipid profile were assessed along with histopathology of male sex organs.Results: The PA oil supplementation showed pronounced fertility outcomes in terms of raised litter size, sex hormones and antioxidant markers in both generations. Moreover, in ethanol-induced male infertility model, PA oil significantly restored sex hormones, ROS and GPx levels. Histological findings also endorsed better spermatogenesis with enhanced architecture.Conclusion: These results strongly suggest that PA oil rich in PUFA (poly-unsaturated fatty acids) might be a promising treatment option in future for male/female sterility.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Fertility, Sex hormones, Oxidative stress, Almond, Infertility models, Two-generation study, Ethanol</keyword>
				<start_page>816</start_page>
				<end_page>837</end_page>
				<web_url>https://ajp.mums.ac.ir/article_24590.html</web_url>
			<author_list><author>
				<first_name>Sadia</first_name>
				<middle_name>Suri</middle_name>
				<last_name>Kashif</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sadia.kashif@zu.edu.pk</email>
				<code>107768</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sadaf</first_name>
				<middle_name></middle_name>
				<last_name>Naeem</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sadaf.naeem@jsmu.edu.pk</email>
				<code>107767</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Saira</first_name>
				<middle_name>Saeed</middle_name>
				<last_name>Khan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>saira.khan@uok.edu.pk</email>
				<code>107769</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Aisha</first_name>
				<middle_name></middle_name>
				<last_name>Razzaque</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email></email>
				<code>107770</code>
				<coreauthor>No</coreauthor>
				<affiliation>Obstetrics and Gynaecology, Queen Medical Centre, Nottingham University Hospitals, Nottingham, United Kingdom</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Antioxidant effects and protective potential of fruit extracts of Detarium microcarpum against arsenic trioxide-induced human lymphocytes DNA oxidative damages</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: The integrity of the DNA is continously menaced by the harmful genotoxic compounds. The endogenous system responsible for preserving the DNA integrity, often fails following a massive influx of these genotoxic compounds. Reseaches on exogenous bioactive compounds from fruits and vegetables are necessary.  This study was designed to evaluate the free radical scavenging activity and the DNA protection/repair potentiality of the extracts of Detarium microcarpum fruit pulp to protect against the arsenic trioxide-induced DNA oxidative degradation.Materials and Methods: The ability of extracts to trap free radicals was assessed by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide and hydroxyle radicals quenching assay. The comet assay was performed for evaluating the DNA protection/repair property of extracts to inhibit the DNA oxidative damage induced by arsenic trioxide.Results: All extracts at a final concentration of 50 µg/mL have quenched more than 50% of DPPH, nitric oxide and hydroxyle radicals. Moreover, all extracts have showed good DNA protection/repair activity against the arsenic trioxide-induced DNA oxidative damage compared to arsenic treatment alone (p&lt;0.001). However, methanol fractions have exhibited the best DNA protection/repair activities by reducing considerably DNA fragmentations compared to arsenic treatment (p&lt;0.001). The genoprotective activity of the extracts was positively correlated with their free radical scavenging abilities.Conclusion: The methanol fraction of D. microcarpum fruits have exhibited interesting DNA protection /repair properties probably due to its free radicals quenching ability. Further investigations are necessary to identify the phytomolecules responsible for these biological activities.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Arsenic Trioxide, Detarium microcarpum, DNA repair, Phytomolecules</keyword>
				<start_page>838</start_page>
				<end_page>847</end_page>
				<web_url>https://ajp.mums.ac.ir/article_24842.html</web_url>
			<author_list><author>
				<first_name>Ablassé</first_name>
				<middle_name></middle_name>
				<last_name>Rouamba</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rouambaablasse@gmail.com</email>
				<code>108975</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Laboratoire de Biochimie et Chimie Appliquées (LABIOCA), UFR-SVT, Université Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Burkina Faso</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Vincent</first_name>
				<middle_name></middle_name>
				<last_name>Ouedraogo</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>vicenteoued@gmail.com</email>
				<code>108976</code>
				<coreauthor>No</coreauthor>
				<affiliation>Laboratoire de Biochimie et Chimie Appliquées (LABIOCA), UFR-SVT, Université Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Burkina Faso</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Maurice</first_name>
				<middle_name></middle_name>
				<last_name>Ouédraogo</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ouedraogo_maurice@yahoo.fr</email>
				<code>108977</code>
				<coreauthor>No</coreauthor>
				<affiliation>Laboratoire de Physiologie Animale (LAPA), UFR-SVT, Université Joseph KI-ZERBO, 09 BP 848, Ouagadougou 09, Burkina Faso</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Martin</first_name>
				<middle_name></middle_name>
				<last_name>Kiendrebeogo</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rouambass@yahoo.fr</email>
				<code>108978</code>
				<coreauthor>No</coreauthor>
				<affiliation>Laboratoire de Biochimie et Chimie Appliquées (LABIOCA), UFR-SVT, Université Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Burkina Faso</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>The therapeutic potential of Ma'aljobon, a whey product, in primary hypertension: A double-blind randomized controlled trial</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Ma’aljobon is used in Persian medicine (PM) as a natural antihypertensive product. This study aimed to evaluate the hypotensive effect of Ma’aljobon in patients with uncontrolled grade 1 primary hypertension (HTN).Materials and Methods: This double-blind, placebo-controlled clinical trial included 114 patients (20-80 years) with uncontrolled grade 1 primary HTN. After obtaining informed consent, the participants were randomly divided into two groups and administered with 25g of Ma’aljobon or maltodextrin twice daily for six weeks. Systolic and diastolic blood pressures (SBP and DBP, respectively) were analyzed.Results: A total of 97 patients (52.3±10.7 years, %53.6 female) completed the study. In the Ma’aljobon group, SBP decreased from 150.3±12.3 to 130.6±12.1 mm Hg, and DBP decreased from 93.3±8.2 to 80.1±6.6 mm Hg (p&lt;0.001). In the control group, SBP decreased from 147.6±11.2 to 138.7±14.4 mm Hg, and DBP decreased from 86.6±7.7 to 82.2±8.2 mm Hg (p&lt;0.001). There was a significant difference in the changes of SBP and DBP between the two groups over time (p&lt;0.001). No adverse events were observed.Conclusion: Ma’aljobon has a stronger hypotensive effect than placebo in patients with HTN and can be recommended as an add-on therapy for uncontrolled HTN.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Hypertension, Persian Medicine, Whey Proteins, Traditional Medicine</keyword>
				<start_page>848</start_page>
				<end_page>859</end_page>
				<web_url>https://ajp.mums.ac.ir/article_24921.html</web_url>
			<author_list><author>
				<first_name>Asie</first_name>
				<middle_name></middle_name>
				<last_name>Shojaii</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>shojaii.a@iums.ac.ir</email>
				<code>109260</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Traditional Pharmacy, Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Roshanak</first_name>
				<middle_name></middle_name>
				<last_name>Ghods</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ghods.r@iums.ac.ir</email>
				<code>109261</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Traditional Medicine, Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fataneh</first_name>
				<middle_name></middle_name>
				<last_name>Hashem-Dabaghian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dabaghian.f@iums.ac.ir</email>
				<code>109262</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Traditional Medicine, Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Maryam</first_name>
				<middle_name></middle_name>
				<last_name>Navabzadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mnavab94@gmail.com</email>
				<code>109263</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Persian Medicine, Birjand University of Medical Sciences, Birjand, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Tooba</first_name>
				<middle_name></middle_name>
				<last_name>Kazemi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>drtooba.kazemi@gmail.com</email>
				<code>109264</code>
				<coreauthor>No</coreauthor>
				<affiliation>Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Morné</first_name>
				<middle_name></middle_name>
				<last_name>Weyers</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>weyers.m@ufs.ac.za</email>
				<code>109265</code>
				<coreauthor>No</coreauthor>
				<affiliation>African Medicines Innovations and Technologies Development (AMITD), Indigenous knowledge based Medicines and Innovations Centre, School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein 9300, South Africa</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Motlalepula G.</first_name>
				<middle_name></middle_name>
				<last_name>Matsabisa</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>matsabisamg@ufs.ac.za</email>
				<code>109266</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, African Medicines Innovations and Technologies Development (AMITD), Indigenous knowledge based Medicines and Innovations Centre, School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein 9300, South Africa</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>The protective properties of resveratrol against glycerol-induced acute kidney injury in rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: After rhabdomyolysis, muscle tissue releases substances such as myoglobin, creatine kinase, and electrolytes into the bloodstream, potentially leading to acute kidney injury (AKI). Resveratrol (RSV) is a polyphenol compound with anti-inflammatory and antioxidant effects and it is found in various plants. This research evaluated the protective effects of RSV in rhabdomyolysis-induced AKI in rat kidneys.Materials and Methods: Thirty-six male Wistar rats were randomly assigned to six groups (n=6): 1) control (normal saline), 2) glycerol only (10 ml/kg, intramuscular), 3, 4, and 5) glycerol +RSV (5, 10, and 25 mg/kg, intraperitoneal injection) and 6) RSV (25 mg/kg). After 4 days, pathological alterations and the level of blood urea nitrogen (BUN) and serum creatinine were determined. Malondialdehyde (MDA), glutathione (GSH), neutrophil gelatinase-associated lipocalin (NGAL), and tumor necrosis factor-α (TNF-α) proteins were investigated in rat kidneys. Results: Injection of 50% glycerol (10 ml/kg, IM) resulted in pathological lesions, elevated levels of MDA (p&lt;0.001), BUN (p&lt;0.01), serum creatinine (p&lt;0.001), TNF-α (p&lt;0.01), and NGAL protein (p&lt;0.001), and decreased GSH content (p&lt;0.001) compared to the control animals. These findings indicated AKI induced by rhabdomyolysis. RSV (25 mg/kg) administration significantly decreased serum creatinine, BUN, MDA, NGAL, and TNF-α levels compared to the glycerol group. Histopathologically, tubule necrosis, myoglobin cast formation and glomerular atrophy increased in the glycerol group and reduced in animals that received RSV.Conclusion: In the glycerol-induced AKI rat model, RSV administration alleviated renal dysfunction by reducing oxidative stress and inflammatory responses.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>rhabdomyolysis, Acute renal failure, Grape, Inflammation</keyword>
				<start_page>860</start_page>
				<end_page>873</end_page>
				<web_url>https://ajp.mums.ac.ir/article_24649.html</web_url>
			<author_list><author>
				<first_name>Mohammadreza</first_name>
				<middle_name></middle_name>
				<last_name>Baghishani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>baghishanimr991@mums.ac.ir</email>
				<code>108067</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Soghra</first_name>
				<middle_name></middle_name>
				<last_name>Mehri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mehris@mums.ac.ir</email>
				<code>108068</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Tahereh</first_name>
				<middle_name></middle_name>
				<last_name>Aminifard</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>aminifardt971@mums.ac.ir</email>
				<code>108069</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Amirhossein</first_name>
				<middle_name></middle_name>
				<last_name>Jafarian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>jafrianah@mums.ac.ir</email>
				<code>108070</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pathology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hossein</first_name>
				<middle_name></middle_name>
				<last_name>Hosseinzadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hosseinzadehh@mums.ac.ir</email>
				<code>108071</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Regulation of the microRNA profiles related to Myh7 and Myh6 in myocardial ischemia through proanthocyanidins and different intensity exercise training</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Myocardial ischemia (MI) and circulatory arrest are associated with unfavorable cardiovascular outcomes. This study aims to investigate the effects of proanthocyanidins (PC) and regular exercise with various intensity training protocols (low, moderate, and high) on cardiac protection in a rat model of MI induced by isoproterenol.Materials and Methods: Based on bioinformatics, a pool of microRNAs and mRNAs was assessed according to significant differential expression in MI condition. Further, the networks of hub genes and mRNA-microRNAs were constructed. After 14 weeks of low, moderate, and high-intensity interval training and oral administration of 300 mg/kg of PC, MI was established in the rats by injecting isoproterenol. The real-time qPCR assessed the relative expressions.Results: Based on the in-silico analysis, Fn1 (fibronectin-1) and Myh7 (myosin heavy chain 7) are potentially druggable cut points to reduce cardiac tissue damage. High-intensity interval training (HIIT) and consumption of PC modified the relative expression of Myh6 (myosin heavy chain 6), Myh7, and Nf1. Moreover, High-intensity interval  training and PC regulated the mir92a-3p, mir181a-5p, mir29a-3p, and mir133a-3p.Conclusion: Here, the data indicated that the HIIT protocol could have an effective strategy compared to low-intensity interval training (LIIT) and moderate-intensity interval training protocols (MIIT). Furthermore, HIIT and PC might have protective effects on the MI condition.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Proanthocyanidins, High-intensity interval training, Myocardial ischemia, mRNA, microRNAs</keyword>
				<start_page>874</start_page>
				<end_page>889</end_page>
				<web_url>https://ajp.mums.ac.ir/article_24739.html</web_url>
			<author_list><author>
				<first_name>Safar</first_name>
				<middle_name></middle_name>
				<last_name>Zarei</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>safarzarei@yahoo.com</email>
				<code>108503</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Farzaneh</first_name>
				<middle_name></middle_name>
				<last_name>Taghian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>f_taghian@yahoo.com</email>
				<code>108504</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Gholamreza</first_name>
				<middle_name></middle_name>
				<last_name>Sharifi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>gre_sharifi@yahoo.com</email>
				<code>108505</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hassanali</first_name>
				<middle_name></middle_name>
				<last_name>Abedi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hassanaliabedi@jums.ac.ir</email>
				<code>108506</code>
				<coreauthor>No</coreauthor>
				<affiliation>Research Center for Non-Communicable Diseases, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Anti-oxidant and anti-apoptotic effects of gamma-oryzanol on male reproductive function in chronic restraint stress in rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: This study investigates the effects of GO on depressive behaviors and reproductive parameters in rats exposed to CRS.Materials and Methods: Rats were divided into three groups: sham, CRS-control, and CRS-GO. Behavioral assessments using the SPT and measurements of body and testes weights were conducted. Reproductive potential was evaluated by ELISA for testosterone, LH, and FSH levels, as well as sperm characteristics. Oxidative stress levels were assessed through MDA measurements and antioxidant enzyme activities. Additionally, apoptotic and signaling pathway proteins were analyzed by measuring cleaved caspase-3 and Nrf-2 levels in the testes using western blot analysis. Results: GO mitigated depressive behaviors and reduced serum corticosterone levels compared to the CRS-control group. GO increased testosterone, LH, and FSH levels and improved sperm parameters. GO supplementation reduced MDA levels and enhanced antioxidant enzyme activities compared to the CRS-control group. The analysis showed that GO down-regulated cleaved caspase-3 levels and up-regulated Nrf-2 protein levels in the testes of CRS rats compared to the CRS-control group. Conclusion: The administration of GO treatment can contribute to the recovery from male reproductive complications by regulating oxidative stress and apoptotic pathways.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Gamma-oryzanol, Chronic restraint stress, Sperm Parameters, Apoptosis, Oxidative stress</keyword>
				<start_page>890</start_page>
				<end_page>906</end_page>
				<web_url>https://ajp.mums.ac.ir/article_24819.html</web_url>
			<author_list><author>
				<first_name>Mahsan</first_name>
				<middle_name></middle_name>
				<last_name>Alizadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>alizadehmahsan5@gmail.com</email>
				<code>108879</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sina</first_name>
				<middle_name></middle_name>
				<last_name>Moshtagh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>s.moshtagh@razi.ac.ir</email>
				<code>108880</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Science, Theriogenology Section, School of Veterinary Medicine, Razi University, Kermanshah, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Shahabaddin</first_name>
				<middle_name></middle_name>
				<last_name>Abdolalizadeh Amir</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>shahabaddinabdolalizadehamir@gmail.com</email>
				<code>108881</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mostafa</first_name>
				<middle_name></middle_name>
				<last_name>Jeddi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mjeddy95@gmail.com</email>
				<code>108882</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sepehr</first_name>
				<middle_name></middle_name>
				<last_name>Tahmasebzadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sep.t.dvm@gmail.com</email>
				<code>108883</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ghazal</first_name>
				<middle_name></middle_name>
				<last_name>Radman</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ghazalradmannn@gmail.com</email>
				<code>108884</code>
				<coreauthor>No</coreauthor>
				<affiliation>Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Amin</first_name>
				<middle_name></middle_name>
				<last_name>Bagheri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>bagheria@tbzmed.ac.ir</email>
				<code>108886</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Urology, Sina Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Yasin</first_name>
				<middle_name></middle_name>
				<last_name>Bagheri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dr.yasinbagheri@yahoo.com</email>
				<code>108878</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Kidney Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Nazanin</first_name>
				<middle_name></middle_name>
				<last_name>Shahabinejad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>n.shahabi@kmu.ac.ir</email>
				<code>108885</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Effect of lupeol on testicular lesions induced by cadmium chloride in rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Heavy metals and environmental pollutants, such as cadmium chloride, congenital disorders, and certain diseases, can lead to infertility in men. In this study, the effects of lupeol (an active pentacyclic triterpenoid with antioxidant properties) on testicular injuries induced by cadmium chloride were investigated in male rats.Materials and Methods: Lupeol was obtained from Sigma-Aldrich, and the experiment included 40 male Wistar rats divided into 8 groups (healthy control, healthy rats treated with 100, 200, and 400 mg/kg of lupeol, cadmium chloride, and three groups that received cadmium chloride and were treated with 100, 200, and 400 mg/kg of lupeol). After oral treatment, rats were anesthetized, and blood and testicular tissue sampling was done. Subsequent analysis of oxidative stress enzymes, such as malondialdehyde (MDA) and superoxide dismutase (SOD), testosterone, sperm motility, and Aquaporin 9 (AQ9) levels was performed using ELISA, histopathology, and immunohistochemistry techniques, respectively. Immunohistochemistry staining was done for expression of Aquaporin 9 in seminiferous tubules.Results: The results showed that compared to the healthy control, cadmium chloride caused a significant decrease in SOD, testosterone, sperm motility, and sperm vitality, with severe destruction of spermatogenic tubes and a significant increase in MDA and AQ9 rate. Rats which were treated with cadmium chloride+400 mg/kg of lupeol showed a significant increase in SOD, testosterone, histopathology, sperm motility, and sperm vitality rate, and significant organization of spermatogenic tubes in testis tissue. There was also a decrease in MDA and AQ9 of rats that received high-dose lupeol. (P&lt;0.001)Conclusion: This study suggests that lupeol has a high potential for improving male reproduction and antioxidants in rats exposed to oxidative stress.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Infertility, Lupeol, Cadmium chloride, Malondialdehyde, Superoxide Dismutase</keyword>
				<start_page>907</start_page>
				<end_page>919</end_page>
				<web_url>https://ajp.mums.ac.ir/article_24716.html</web_url>
			<author_list><author>
				<first_name>Parmida</first_name>
				<middle_name></middle_name>
				<last_name>Arabkarami</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>parmida.arabkarami@gmail.com</email>
				<code>108397</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Pejman</first_name>
				<middle_name></middle_name>
				<last_name>Mortazavi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sp.mortazavi@gmail.com</email>
				<code>108396</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Saeed</first_name>
				<middle_name></middle_name>
				<last_name>Hesaraki</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>s.hesaraki@srbiau.ac.ir</email>
				<code>108398</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>