<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Avicenna Journal of Phytomedicine</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ajp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2228-7930</journal_id_issn>
			<journal_id_issn_online>2228-7949</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2016</year>
				<month>3</month>
				<day>1</day>
			</pubdate>
			<volume>6</volume>
			<number>2</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Anti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Short communication</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objectives: Ziziphus Jujube (Jujube) plant has exhibited numerous medicinal and pharmacological properties including antioxidant and anti-inflammatory effects. This study was carried out to investigate its anti-cancer and pro-apoptotic abilities in human cervical and breast cancer cells in vitro. Materials and Methods: The cervical OV2008 and breast MCF-7 cancer cells were incubated with different concentrations of Jujube aqueous extraction (0-3 mg/ml) for various times (0-72 h). Cell viability was assessed by Trypan Blue and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The expression of two apoptosis-related genes in treated cells evaluated by quantitative Real Time -PCR analysis. Results: Jujube significantly inhibited cancer cell viability in a dose- and time- dependent manner. Herb-induced apoptosis was associated with enhanced expression of Bax and decreased Bcl2 gene leading eventually to a time-dependent six fold increase in the Bax/Bcl-2 ratio. Conclusions: These results indicated that Jujube may be a natural potential and promising agent to prevent or treat human cancers.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Ziziphus Jujube, Cervical Cancer, Breast Cancer, Apoptosis</keyword>
				<start_page>142</start_page>
				<end_page>148</end_page>
				<web_url>https://ajp.mums.ac.ir/article_5345.html</web_url>
			<author_list><author>
				<first_name>Mohammad Reza</first_name>
				<middle_name></middle_name>
				<last_name>Abedini</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mohrabe@yahoo.com</email>
				<code>21061</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Nafiseh</first_name>
				<middle_name></middle_name>
				<last_name>Erfanian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nafiseherfanian@yahoo.com</email>
				<code>21062</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biology, Payam-e Noor University of Esfahan, Esfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Habibollah</first_name>
				<middle_name></middle_name>
				<last_name>Nazem</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>habibnazem@gmail.com</email>
				<code>21063</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biology, Payam-e Noor University of Esfahan, Esfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sara</first_name>
				<middle_name></middle_name>
				<last_name>Jamali</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sara.jamali89@gmail.com</email>
				<code>21064</code>
				<coreauthor>No</coreauthor>
				<affiliation>Cellular &amp; Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Reyhane</first_name>
				<middle_name></middle_name>
				<last_name>Hoshyar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hooshyar@bums.ac.ir</email>
				<code>21065</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>