<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Avicenna Journal of Phytomedicine</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ajp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2228-7930</journal_id_issn>
			<journal_id_issn_online>2228-7949</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2014</year>
				<month>9</month>
				<day>1</day>
			</pubdate>
			<volume>4</volume>
			<number>5</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Lipid-lowering activity of Cow urine ark in guinea pigs fed with a high cholesterol diet</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objectives: Cow urine ark (CUA), known as “Amrita” as mentioned in Ayurveda, contains‎ anti-hyperglycemic and antioxidant effects. Therefore, we designed the present study to evaluate the lipid ‎lowering activity of CUA and its possible implication in metabolic syndrome.‎ Materials and Methods: Thirty guinea pigs of either sex were divided into five groups: Group 1 and 2 serving as a vehicle ‎and sham control, received normal and high fat diet for 60 days respectively; Group 3, 4 and 5 ‎received high fat diet for 60 days with CUA 0.8 ml/kg, 1.6 ml/kg and rosuvastatin (1.5 mg/kg) on the‎last 30 days of study period, respectively. Serum lipid profile (total cholesterol, triglycerides, LDL-‎C, VLDL-C, HDL-C, total Cholesterol/HDL-C) and serum enzymes (ALT, AST, ALP, LDH and CK-MB) ‎were performed in each group at the beginning and end of the study. Histological study of liver and ‎kidney was done in each group. Results: CUA (0.8 ml/kg) significantly decreased the serum triglycerides and VLDL-C, but CUA (1.6 ml/kg) ‎decreased the total serum Cholesterol, triglycerides and VLDL-C (p &lt; 0.05). Higher dose (1.6 ml/kg) of ‎CUA also increased HDL-C level, significantly (p &lt; 0.05). CUA reduced serum AST, ALP and LDH ‎level, which was statistically significant as well, while it also decreased the accumulation of lipid in hepatocytes as ‎compared to sham control.‎ Conclusions: CUA reduced triglycerides, increased HDL-C and found to be hepatoprotective in ‎animals that are on a high fat diet.  ]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Antioxidant activity, Cow urine ark, Dyslipidemia, Hypolipidemia, Guinea pig, Statin</keyword>
				<start_page>354</start_page>
				<end_page>363</end_page>
				<web_url>https://ajp.mums.ac.ir/article_3036.html</web_url>
			<author_list><author>
				<first_name>Hiren Manubhai</first_name>
				<middle_name></middle_name>
				<last_name>Chawda</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hiren_chawda1987@yahoo.co.in</email>
				<code>11118</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, Government Medical College, Bhavnagar-364001, Gujarat, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Divyesh Rasiklal</first_name>
				<middle_name></middle_name>
				<last_name>Mandavia</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>drdivyeshmandavia@gmail.com</email>
				<code>11119</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, Government Medical College, Bhavnagar-364001, Gujarat, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Seema Natvarlal</first_name>
				<middle_name></middle_name>
				<last_name>Baxi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>seemabaxi@gmail.com</email>
				<code>11120</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pathology, Government Medical College, Bhavnagar-364001, Gujarat, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Vishalkumar Kishorbhai</first_name>
				<middle_name></middle_name>
				<last_name>Vadgama</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dr.vishalvadgama@gmail.com</email>
				<code>11121</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, Government Medical College, Bhavnagar-364001, Gujarat, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Chandrabhanu Rajkishor</first_name>
				<middle_name></middle_name>
				<last_name>Tripathi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>cbrtripathi@yahoo.co.in</email>
				<code>11122</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pharmacology, Government Medical College, Bhavnagar-364001, Gujarat, India</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>