<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Avicenna Journal of Phytomedicine</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ajp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2228-7930</journal_id_issn>
			<journal_id_issn_online>2228-7949</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<volume>16</volume>
			<number>4</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>The effect of curcumin-piperine supplementation on liver transient elastography and biochemical indices in patients with non-alcoholic fatty liver disease: A randomized controlled trial</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Non-alcoholic fatty liver disease (NAFLD), characterized by an excessive buildup of triglycerides in hepatocytes, currently lacks an approved pharmacological treatment. This study investigated the therapeutic potential of a curcumin-piperine supplement, leveraging curcumin&#039;s established antioxidant, anti-inflammatory, anti-steatotic, and anti-fibrotic properties, with piperine enhancing its bioavailability. The objective was to assess its impact on cardiometabolic markers, liver function, and the progression of hepatic steatosis and fibrosis.Materials and Methods: Sixty NAFLD patients were enrolled in a randomized, 12-week, placebo-controlled study. Participants were randomly assigned to a treatment group receiving a daily oral supplement of 500 mg curcumin and 5 mg piperine, or a control group receiving a placebo. Measurements of anthropometrics, biochemical indices, and hepatic steatosis and fibrosis via FibroScan were taken at baseline and study end.Results: Anthropometric indices, and hepatic fibrosis decreased significantly within groups but not between groups for curcumin-piperine supplementation compared to placebo (p&lt;0.05). There were no significant differences between curcumin-piperine supplementation and placebo in total cholesterol, LDL-C (low-density lipoprotein, cholesterol), HDL-C (high-density lipoprotein, cholesterol), ALT (alanine transaminase), AST (aspartate transaminase), FBS (fasting blood sugar) and hepatic steatosis after 12 weeks.Conclusions: Curcumin-piperine supplementation showed no significant impact on hepatic or biochemical markers linked to NAFLD when compared to placebo, suggesting it may not be a beneficial adjunct therapy.Methods: Sixty patients diagnosed with non-alcoholic fatty liver disease (NAFLD) were enrolled in a randomized, 12-week, placebo-controlled study. Participants were randomly assigned to one of two groups: a treatment group receiving a daily oral supplement of 500 mg curcumin and 5 mg piperine, or a control group receiving a 505 mg microcrystalline cellulose placebo. Anthropometric measurements, biochemical indices, and assessments of hepatic steatosis and fibrosis via FibroScan were conducted at both baseline and at the conclusion of the 12-week intervention period.Results: Anthropometric indices (weight, BMI, waist circumference), and hepatic fibrosis decreased significantly within groups but not between groups for curcumin-piperine supplementation compared to placebo (p&lt;0.05).There were no significant differences between curcumin-piperine supplementation and placebo on total cholesterol, low density lipoprotein-C, high density lipoprotein-C, alanine aminotransferase, aspartate transaminase, fasting glucose and hepatic steatosis after 12 weeks. Conclusions: Compared to placebo, curcumin-piperine supplementation did not affect any of the hepatic or biochemical markers associated with NAFLD and would not appear to be an effective adjunct therapy.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Curcumin Fibrosis non, alcoholic fatty liver disease Piperine Steatosis</keyword>
				<start_page>696</start_page>
				<end_page>711</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26943.html</web_url>
			<author_list><author>
				<first_name>Sahar</first_name>
				<middle_name></middle_name>
				<last_name>Rafiee</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rafiee.nut@gmail.com</email>
				<code>118275</code>
				<coreauthor>No</coreauthor>
				<affiliation>Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan
University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad</first_name>
				<middle_name></middle_name>
				<last_name>Bagherniya</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>bagherniya@yahoo.com</email>
				<code>118276</code>
				<coreauthor>No</coreauthor>
				<affiliation>Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan
University of Medical Sciences, Isfahan, Iran
|Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ziba</first_name>
				<middle_name></middle_name>
				<last_name>Khoram</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>dr.khorram99@gmail.com</email>
				<code>118277</code>
				<coreauthor>No</coreauthor>
				<affiliation>Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Amrollah</first_name>
				<middle_name></middle_name>
				<last_name>Ebrahimi Varzaneh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>a_ev11@yahoo.com</email>
				<code>118278</code>
				<coreauthor>No</coreauthor>
				<affiliation>Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>Heidari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>heidari.biostat.64@gmail.com</email>
				<code>118279</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran|5
Isfahan Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Thozhukat</first_name>
				<middle_name></middle_name>
				<last_name>Sathyapalan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>thozhukat.sathyapalan@hyms.ac.uk</email>
				<code>118280</code>
				<coreauthor>No</coreauthor>
				<affiliation>Academic Diabetes, Endocrinology and Metabolism, Allam Diabetes Centre Hull Royal Infirmary Anlaby Road HU3 2JZ, Hull, UK</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Amir Hossein</first_name>
				<middle_name></middle_name>
				<last_name>Sahebkar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>amir_saheb2000@yahoo.com</email>
				<code>118281</code>
				<coreauthor>No</coreauthor>
				<affiliation>Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical
Sciences, Saveetha University, Chennai, India
|Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Gholamreza</first_name>
				<middle_name></middle_name>
				<last_name>Askari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>askari@mui.ac.ir</email>
				<code>118282</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan
University of Medical Sciences, Isfahan, Iran|Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>