<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Avicenna Journal of Phytomedicine</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ajp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2228-7930</journal_id_issn>
			<journal_id_issn_online>2228-7949</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>5</month>
				<day>1</day>
			</pubdate>
			<volume>16</volume>
			<number>3</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Protective effects auraptene alone and in combination with estradiol on intestine injury induced by traumatic brain injury in male rats: The role of oxidative stress</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: This investigation aimed to evaluate how varying doses of auraptene (AUR) alone and in combination with estradiol (E2) on various parameters after traumatic brain injury (TBI) in rats.Materials and Methods: The rats were divided into twelve groups, including a sham group and eleven TBI groups. The TBI groups consisted of three vehicle groups (DMSO, Oil, and DMSO+Oil), an E2 group, three AUR groups with varying doses (4, 8, and 25 mg/kg), and three combination groups of AUR and E2 (AUR 4+E2, AUR 8+E2, and AUR 25+E2).AUR was administered for five consecutive days) ip). TBI was induced 30 minutes after the last injection on the fifth day.E2 and Oil were injected 30 minutes post-TBI.Results: AUR at 25 mg/kg and in combination with E2 significantly reduced brain water content. Nitric Oxide (NO) and Malondialdehyde (MDA) levels were lower in AUR 8 and 25, and all AUR+E2 groups. Glutathione peroxidase (GPX) and Catalase (CAT) activity increased in all AUR+E2 groups. TBI increased interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α) levels in the intestine, which were reduced by AUR alone and AUR+E2Conclusion: These findings support AUR, particularly with E2, as a promising therapeutic strategy for managing oxidative stress, inflammation, and tissue damage in TBI cases.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>TBI, Auraptene, Estrogen, Oxidative stress, Neuroprotection</keyword>
				<start_page>577</start_page>
				<end_page>589</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26871.html</web_url>
			<author_list><author>
				<first_name>Zakieh</first_name>
				<middle_name></middle_name>
				<last_name>Keshavarzi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zakieh_keshavarzi@yahoo.com</email>
				<code>117966</code>
				<coreauthor>No</coreauthor>
				<affiliation>Professor of medical physiology, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Azadeh</first_name>
				<middle_name></middle_name>
				<last_name>Seyedjoodaki</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>azadehseyedjoodaki@gmail.com</email>
				<code>117967</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Immunology, School of Medicine. Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ahmad</first_name>
				<middle_name></middle_name>
				<last_name>Vosughi Motlagh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>vosough@gmail.com</email>
				<code>117968</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pediatrics, North Khorasan University of Medical Sciences, Bojnurd, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Amirreza</first_name>
				<middle_name></middle_name>
				<last_name>Afshari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>amirrezaafshari@gmail.com</email>
				<code>117969</code>
				<coreauthor>No</coreauthor>
				<affiliation>dAssistant Professor of Medical Pharmacology, Department of Physiology and Pharmacology, Faculty of Medicine, North Khorasan University of Medical Sciences (NKUMS), Bojnurd, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fatemeh</first_name>
				<middle_name></middle_name>
				<last_name>Maghool</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>maghol@yahoo.com</email>
				<code>117970</code>
				<coreauthor>No</coreauthor>
				<affiliation>Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sedigheh</first_name>
				<middle_name></middle_name>
				<last_name>Amiresmaili</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>esmailisedigheh@yahoo.com</email>
				<code>117971</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>bam univercity of medical sciencess</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>