<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Avicenna Journal of Phytomedicine</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ajp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2228-7930</journal_id_issn>
			<journal_id_issn_online>2228-7949</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>3</month>
				<day>1</day>
			</pubdate>
			<volume>16</volume>
			<number>2</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Dexamethasone-induced hepatic biochemical and pathological damages are attenuated by Cynodon dactylon extract containing hexadecanoic acid via reduction of glucose uptake: In vitro and in vivo studies</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: The protective effects of ethanolic extract of Cynodon dactylon (CD) on dexamethasone (DEX)-induced hepatic injuries were investigated.Materials and Methods: Following GC-MS phytochemical analyses of the extract, in vivo studies were conducted in male rats which were grouped as: control, dexamethasone (8mg/kg, intraperitoneally), DEX+CD (100, 200 and 400 mg/kg, orally), CD 400 and DEX+metformin (MET, 300mg/kg, orally) for 15 days. The in vitro studies were performed in HepG2 cells that grouped as: Control, DEX (1 µM), DEX+CD (0.1, 0.5 and 1 mg/ml), CD 0.5 mg/ml, and DEX+MET (500 µM). Cell viability and animal weight changes were recorded. Following the study period, biochemical and histopathological analyses were conducted on hepatic tissue and HepG2 cells.Results: Findings revealed that CD extract does have concentration-dependent free radical-scavenging activity, and it possesses phenols and flavonoids contents. The most abundant compound of the CD extract was n-hexadecanoic acid. The DEX-induced hepatic functional enzymes and lactate dehydrogenase levels were significantly (p&lt;0.05) reduced in both models. Moreover, the DEX-induced oxidative stress was improved by CD extract (45%). The DEX-elevated blood glucose (20%) and triglycerides (60%) were reduced in CD-treated animals. The DEX-generated hepatic macrovesicles and lipid droplets in HepG2 cells were reduced.Conclusion: These results suggest that CD extract could be an effective compound for protection from DEX-induced hepatic injuries.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Dexamethasone, Hepatic injuries, Hypolipidemic effect, glucose uptake</keyword>
				<start_page>367</start_page>
				<end_page>385</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26623.html</web_url>
			<author_list><author>
				<first_name>Sadaf</first_name>
				<middle_name></middle_name>
				<last_name>Mottaghian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sadafy.m.97@gmail.com</email>
				<code>116876</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ayshin</first_name>
				<middle_name></middle_name>
				<last_name>Khalilarya</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ayshinkhalilarya@gmail.com</email>
				<code>116877</code>
				<coreauthor>No</coreauthor>
				<affiliation>Experimental &amp; Applied Pharmaceutical Sciences Research Center, Urmia University of Medical Sciences, Urmia, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hassan</first_name>
				<middle_name></middle_name>
				<last_name>Malekinejad</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hassanmalekinejad@yahoo.com</email>
				<code>116878</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>a Experimental &amp; Applied Pharmaceutical Sciences Research Center, Urmia University of Medical Sciences, Urmia, Iran;
b Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>