<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Avicenna Journal of Phytomedicine</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ajp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2228-7930</journal_id_issn>
			<journal_id_issn_online>2228-7949</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>3</month>
				<day>1</day>
			</pubdate>
			<volume>16</volume>
			<number>2</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Vitex agnus-castus extract improved the endocrine profile and important gene expression in rat ovaries with polycystic ovary syndrome</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: The beneficial effect of Vitex agnus-castus on the female endocrine system has been reported. This study examines the impact of Vitex extract (VE) on the serum anti-Mullerian hormone (AMH), sex hormones, and P450arom, AMH, and CTRP6 gene expression in the ovaries of a rat model of PCOS.Materials and Methods: Thirty-two rats with regular estrous cycles were enrolled as controls, polycystic ovary syndrome (PCOS), and two treatment groups. PCOS was induced by estradiol valerate. The treatment groups (T1 &amp;T2) received VE (150 or 200 mg/kg body weight, respectively) for 30 days following PCOS induction. Serum and left ovary were used to assess hormone levels and P450arom, AMH, and CTRP6 gene expression.Results: In the T2 group, a significant decrease in estradiol (E2, testosterone, and AMH levels (p=0.028) was observed with no significant change in DHEA (p=0.967) in comparison with the PCOS group. AMH in the serum was significantly higher in the PCOS group than in all the other groups (p=0.021). The level of progesterone was not considerably changed between treatments and the PCOS group (p=0.11).  The expression of P450arom in the T2 group was significantly higher than the PCOS group (p=0.003) and had no significant difference from the control (p=0.200). The expression of AMH (p=0.003) and CTRP6 was significantly (p=0.0001) higher in the ovaries of the PCOS group compared to other groups, and consumption of the extract improved the evaluated parameters significantly.Conclusion: The endocrine profile and gene expression were improved in the rat ovary following administration of VE, and therefore, the therapeutic effect of VE may be expected in PCOS.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>AMH PCOS P450arom CTRP6 Vitex agnus, castus</keyword>
				<start_page>356</start_page>
				<end_page>366</end_page>
				<web_url>https://ajp.mums.ac.ir/article_26622.html</web_url>
			<author_list><author>
				<first_name>Mahtab</first_name>
				<middle_name></middle_name>
				<last_name>Abbaszadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mahtababaszadeh4791@gmail.com</email>
				<code>116872</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Gholamali</first_name>
				<middle_name></middle_name>
				<last_name>Jelodar</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>jelodar@shirazu.ac.ir</email>
				<code>116873</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Shiraz University</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Saeed</first_name>
				<middle_name></middle_name>
				<last_name>Hossainzadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hosseinzadeh@shirazu.ac.ir</email>
				<code>116874</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department Food hygiene, School of Veterinary Medicine, Shiraz University, Shiraz</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Azam</first_name>
				<middle_name></middle_name>
				<last_name>Salmani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>shymas042@gmail.com</email>
				<code>116875</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>