<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Avicenna Journal of Phytomedicine</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ajp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2228-7930</journal_id_issn>
			<journal_id_issn_online>2228-7949</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2025</year>
				<month>7</month>
				<day>1</day>
			</pubdate>
			<volume>15</volume>
			<number>4</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Protective effect of Henna (Lawsonia inermis L.) fixed oil (a Persian medicine preparation) on acetic acid-induced ulcerative colitis in rats</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Short communication</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Ulcerative colitis is a chronic recurrent inflammatory bowel disease of unknown etiology. The anti-inflammatory, immunomodulatory, and antioxidant characteristics of Henna (Lawsonia inermis) fixed oil (HFO) imply that it may be advantageous for the treatment of colitis.Materials and Methods: In this research, the effect of HFO in a Wistar albino rat model of acetic acid (AA)-induced ulcerative colitis, was examined. The animals received daily oral administration of either normal saline (10 ml/kg), HFO (100, 400, and 1600 µl/kg), or dexamethasone (2 mg/kg) for 5 days. A single intracolonic injection of 2 ml of a 4% (v/v) acetic acid solution was used to induce colitis. The levels of myeloperoxidase (MPO) and tumor necrosis factor-alpha (TNF-α) were measured.Results: The administration of HFO at doses 400 and 1600 μl/kg showed a significant enhancement in the weight-to-length ratio of colon tissue in comparison to the control group. Furthermore, the increased amounts of HFO (400 and 1600 μl/kg) were associated with a significant reduction in ulcer severity, area, and index. However, examination of tissue samples revealed a decrease in the overall colitis index suggesting fewer inflammatory cells invaded the colonic regions of rats treated with HFO at doses of 400 and 1600 μl/kg. Moreover, the elevated MPO levels and TNF-α were significantly decreased following the administration of the fixed oil at these doses.Conclusion: These findings indicate that HFO could potentially decrease the manifestations of experimental colitis in a dose-dependent manner.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Ulcerative colitis, Lawsonia inermis, Fixed oil, Inflammation, Rat</keyword>
				<start_page>1241</start_page>
				<end_page>1251</end_page>
				<web_url>https://ajp.mums.ac.ir/article_25298.html</web_url>
			<author_list><author>
				<first_name>Raheleh</first_name>
				<middle_name></middle_name>
				<last_name>Zareshahi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rahele.zareshahi@gmail.com</email>
				<code>111068</code>
				<coreauthor>No</coreauthor>
				<affiliation>Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences; Department of Traditional pharmacy, School of Persian Medicine, Kerman University of Medical Sciences, Kerman,Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Samane</first_name>
				<middle_name></middle_name>
				<last_name>Jahanabadi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sjahanabadi@yahoo.com</email>
				<code>111069</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sadaf</first_name>
				<middle_name></middle_name>
				<last_name>Rafiyan</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sadaf1993rn@gmail.com</email>
				<code>111070</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Maryam</first_name>
				<middle_name></middle_name>
				<last_name>Yadegary</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>yadegarimy@gmail.com</email>
				<code>111071</code>
				<coreauthor>No</coreauthor>
				<affiliation>Yazd Neuroendocrine Research Center, Faculty of medicine, Shahid Sadoughi University of Medical Sciences and Health services, Yazd, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Roohollah</first_name>
				<middle_name></middle_name>
				<last_name>Edalatkhah</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>drr.edalatkhah@gmail.com</email>
				<code>111072</code>
				<coreauthor>No</coreauthor>
				<affiliation>Hematology and oncology research center, shahid Sadoughi University of medical Sciences, Yazd, Iran
Children Growth Disorder Research Center, shahid Sadoughi University of Medical Sciences, Yazd, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hamed</first_name>
				<middle_name></middle_name>
				<last_name>Mahmoodian</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hamed_mahmoodian@gmail.com</email>
				<code>111073</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacognosy, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>