<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Avicenna Journal of Phytomedicine</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ajp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2228-7930</journal_id_issn>
			<journal_id_issn_online>2228-7949</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2021</year>
				<month>5</month>
				<day>1</day>
			</pubdate>
			<volume>11</volume>
			<number>3</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Arbutin attenuates nephrotoxicity induced by gentamicin</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Short communication</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: In this study, the impact of arbutin was examined in a gentamicin (GM)-induced nephrotoxicity model.Materials and Methods: Forty adult male Wistar rats were randomly assigned to five groups including control group; GM group, and three groups of GM+arbutin (25, 50 and 75 mg/kg). One day after the last injection of GM, creatinine, urea, carbonyl, thiobarbituric acid-reacting substance (TBARs), ferric reducing antioxidant power (FRAP) and 8-hydroxyguanosine levels were assessed in serum samples. Left and right kidneys were used for biochemical assays and histological evaluation, respectively.Results: Our data showed that the FRAP level (p&lt;0.05), urea (p&lt;0.001), creatinine (p&lt;0.001), and 8-hydroxyguanosine (p&lt;0.001) levels of serum samples, were increased in GM-treated rats compared to the controls. The serum levels of TBARS (p&lt;0.001) and carbonyl increased in serum and renal tissue (p&lt;0.001) of GM-treated animals. Conversely, arbutin attenuated serum creatinine, urea and 8-hydroxyguanosine, and TBARS (p&lt;0.001). Administration of arbutin significantly decreased carbonyl levels in serum and renal tissue samples (p&lt;0.001). Furthermore, the levels of FRAP increased in the serum (p&lt;0.01) and renal tissue samples (p&lt;0.001) of arbutin-treated animals. Histological staining showed that arbutin significantly inhibits kidney damages.Conclusion: Our data suggest that arbutin attenuates GM-induced nephrotoxicity through its free radicals-scavenging activity.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Gentamicin, Nephrotoxicity, Arbutin, Antioxidant, Histopathology</keyword>
				<start_page>210</start_page>
				<end_page>217</end_page>
				<web_url>https://ajp.mums.ac.ir/article_16776.html</web_url>
			<author_list><author>
				<first_name>Elnaz</first_name>
				<middle_name></middle_name>
				<last_name>Emadi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>elnaz_emadi@yahoo.com</email>
				<code>71594</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mahdi</first_name>
				<middle_name></middle_name>
				<last_name>Pouramir</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>pouramirmahdi96@gmail.com</email>
				<code>71595</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Maryam</first_name>
				<middle_name></middle_name>
				<last_name>Ghasemi-Kasman</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>maryam.ghasemi65@gmail.com</email>
				<code>71596</code>
				<coreauthor>No</coreauthor>
				<affiliation>Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Farideh</first_name>
				<middle_name></middle_name>
				<last_name>Feizi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>feizif@gmail.com</email>
				<code>71597</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Anatomy, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sohrab</first_name>
				<middle_name></middle_name>
				<last_name>Halalkhor</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>halalkhors43@gmail.com</email>
				<code>71598</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ali Akbar</first_name>
				<middle_name></middle_name>
				<last_name>Moghadamnia</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>moghadamnia67@gmail.com</email>
				<code>71599</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>