<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Avicenna Journal of Phytomedicine</title>
			<title_fa></title_fa>
			<short_title></short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://ajp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn>2228-7930</journal_id_issn>
			<journal_id_issn_online>2228-7949</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2020</year>
				<month>11</month>
				<day>1</day>
			</pubdate>
			<volume>10</volume>
			<number>6</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Phytochemical, anti-inflammatory and analgesic properties of stembark extract and fractions of Lonchocarpus sericeus Poir. (Papilionaceae) in albino mice</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>Original Research Article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Objective: Lonchocarpus sericeusstembark decoction has been extensively employed in folkloric medicine in many parts of Nigeria as a remedy for pain as well as inflammation. The plant was studied for its anti-inflammatory as well as analgesic potency using standard biological models. Materials and Methods: The stembark of L. sericeus was evaluated for anti-inflammatory properties using egg albumin and xylene-induced oedema models. The pain-relieving property was evaluated using acetic acid-induced writhing and thermally-induced pain models. Median lethal dose determination (intraperitoneal LD50), quantification of some phytochemicals as well as phytochemical screening were also performed. Results: The LD50 of stembark extract of L. sericeus was found to be 3,100 mg/kg (i. p). The crude extract and fractions (310-930 mg/kg) effectively reduced oedema caused by egg albumin and xylene and exhibited high analgesic properties in inhibiting pain induced by acetic acid and heat. These reductions were dose-dependent and statistically significant (p &lt;0.05-0.001) when compared to distilled water and similar to prototype drugs employed. Quantitative determinations of some bio-active constituents of the plant showed a higher flavonoid content (0.52±0.02 mg/100 g) compared to alkaloids (0.36±0.02 mg/100 g) and flavonoids (0.49±0.03 mg/100 g). Phytochemical screening of the stembark showed the presence of alkaloids, cardiac glycosides, flavonoids terpenes, tannins and saponins. Conclusion: These  results  imply  that  the stembark  extract  of L. sericeus  possesses anti-inflammatory  and analgesic potency and these data validate its  wide use  in folkloric medicine for inflammation and pain management.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Analgesia, Inflammation, Lonchocarpus sericeus, Phytochemicals</keyword>
				<start_page>584</start_page>
				<end_page>593</end_page>
				<web_url>https://ajp.mums.ac.ir/article_15622.html</web_url>
			<author_list><author>
				<first_name>Uwemedimo</first_name>
				<middle_name>Emmanuel</middle_name>
				<last_name>UDO</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>uwemedimoudo@uniuyo.edu.ng</email>
				<code>66333</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Chemistry, Faculty of Science, University of Uyo, Uyo, Nigeria</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Johnbull</first_name>
				<middle_name>Onyekachi</middle_name>
				<last_name>ECHEME</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>jb.tbulle@gmail.com</email>
				<code>66334</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Chemistry, College of Physical and Applied Sciences,Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Okenwa</first_name>
				<middle_name>Uchenna</middle_name>
				<last_name>IGWE</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>okenwauigwe@gmail.com</email>
				<code>66335</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Chemistry, College of Physical and Applied Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>