TY - JOUR ID - 8032 TI - Protective effect of Tribulus terrestris fruit extract on cerulein-induced acute pancreatitis in mice JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Borran, Mina AU - Minaiyan, Mohsen AU - Zolfaghari, Behzad AU - Mahzuni, Parvin AD - School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran AD - Department of Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran AD - Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran AD - Department of Clinical Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Y1 - 2017 PY - 2017 VL - 7 IS - 3 SP - 250 EP - 260 KW - Acute pancreatitis KW - Inflammation KW - T.terrestris KW - Cerulein KW - Mice DO - 10.22038/ajp.2017.8032 N2 - Objective: Antioxidant, anti-inflammatory, analgesic and antimicrobial activities of Tribulus terrestris (T. terrestris) could be helpful in the treatment of acute pancreatitis; thus, this study was designed to investigate the effects of T. terrestris on cerulein-induced acute pancreatitis in mice. Materials and Methods: Three doses (100, 200 and 400 mg/kg) of T. terrestris hydro-alcoholic extract were administered both orally (60 minutes before pancreatitis induction, p.o.) and intra-peritoneally (30 minutes before pancreatitis induction, i.p.) to different groups of mice (n=6). Pancreatitis was induced by five injections (i.p.) of cerulein 50μg/kg body weight with 1 hr intervals. Animals were euthanized 5 hr after the last injection of cerulein and tissue injures were assessed biochemically and pathologically. Results: T. terrestris extract 200 and 400mg/kg (p.o.) and T. terrestris extract 400 mg/kg (i.p.) reduced pancreatic tissue myeloperoxidase (MPO) activity and serum amylase and lipase levels and alleviated histological parameters. Conclusion: These data suggest that T. terrestris hydro-alcoholic extract was effective in protecting against experimental acute pancreatitis and possibly the efficacy depends on dose and route of administration. UR - https://ajp.mums.ac.ir/article_8032.html L1 - https://ajp.mums.ac.ir/article_8032_b82e3bd78c9c4d3585f386662cf0681a.pdf ER -