TY - JOUR ID - 21872 TI - Falcaria vulgaris L. hydroalcoholic extract protects against harmful effects of mercuric chloride on the rat kidney JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Ghanbari, Ali AU - Jalili, Cyrus AU - Abdolmaleki, Amir AU - Zhaleh, Mohsen AU - Zarinkhat, Armin AU - Akhshi, Nasim AD - Department of Anatomical Sciences, Kermanshah University of Medical Sciences, School of Medicine, Kermanshah, Iran AD - Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran Y1 - 2023 PY - 2023 VL - 13 IS - 4 SP - 442 EP - 453 KW - Antioxidants KW - Kidney KW - Mercuric chloride KW - Nitric oxide KW - Oxidative stress DO - 10.22038/ajp.2023.21872 N2 - Objective: Mercuric chloride (Merc; HgCl2) is toxic to humans and animals and contributes to environmental pollution, which usually results in nerve and systemic harm to different organs. Falcaria vulgaris (FV) is a medicinal plant rich in antioxidants. This research aimed to assess the FV hydroalcoholic extract effects on kidney toxicity induced by Merc.Materials and Methods: Forty-eight male rats were divided into eight groups: the control group: received saline; the Merc group: received 0.5 ml/day of 0.5 ppm aqueous Merc; FV1, 2, and 3 groups: received 50, 100, 150 mg/kg FV, respectively; and Merc + FV1, 2, and 3 groups: received Merc and FV at three doses. The administration period was 14-days. Subsequently, kidneys and sera were cumulated from each group for the analysis. Samples were analyzed via hematoxylin-eosin staining and biochemical tests.Results: The rats that received Merc displayed significant decrement in the kidney index, the diameter of renal corpuscles, total antioxidant capacity levels, superoxide dismutase activity (all, p<0.01), and 150 mg/kg FV mitigated these outcomes (all, p<0.05). Urea, creatinine, nitric oxide, and the level of apoptosis revealed a significant increment in the kidney of the rats that received Merc (all, p<0.01), and 150 mg/kg FV decreased these results. Furthermore, FV ameliorated histological changes induced by Merc (all, p<0.05). Conclusion: The FV hydroalcoholic extract protects the kidneys against Merc-induced nephrotoxicity. Antioxidant and anti-apoptotic FV hydroalcoholic extract properties were involved in this healing effect. UR - https://ajp.mums.ac.ir/article_21872.html L1 - https://ajp.mums.ac.ir/article_21872_5f2337619a2b3b1452cad507a8dc52fd.pdf ER -