TY - JOUR ID - 19491 TI - Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Azizi, Zahra AU - Majlessi, Nahid AU - Choopani, Samira AU - Naghdi, Nasser AD - Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran. Y1 - 2022 PY - 2022 VL - 12 IS - 4 SP - 371 EP - 387 KW - Carvacrol KW - Alzheimer’s disease KW - Neurodegenerative KW - Neuroprotection DO - 10.22038/ajp.2022.19491 N2 - Objective: Neurodegenerative diseases are considered an important cause of cognitive deficit and morbidity in old ages. Alzheimer’s disease (AD) is one of these disorders affecting about 40 million people in the world at the present time. Available drug therapy is mostly symptomatic and does not modify or stop disease progression. Recently, biologically active chemicals from herbs have been studied to develop new therapeutic drugs. Carvacrol has shown positive properties on many neurological diseases. This compound is expected to have the ability to affect AD pathogenesis and therefore, it is considered an anti-AD agent.Materials and Methods: This review was conducted using PubMed, Google Scholar and Science Direct bibliographic databases until November 2021. For data collection, the following keywords were used: carvacrol, neuroprotective, cognition, anti-inflammatory, antioxidant, Acetylcolinesterase inhibitor (AChEI), Alzheimer's, Parkinson’s, epilepsy, stroke, ischemic brain injury, and neurodegenerative diseases.Results: This review summarizes in vitro and in vivo studies on protective potential of carvacrol in neurodegenerative disorders and various underlying mechanisms, such as anti-inflammatory, antioxidant, and anticholinesterase effects. Conclusion: We gave an overview of available literature concerning neuroprotective effects of carvacrol in ameliorating the neurodegenerative diseases symptoms in vivo and in vitro. Particular attention is given to AD. Several neuro-pharmacological actions of carvacrol have been summarized in the current review article including anti-inflammatory, antioxidant, and AChEI properties. UR - https://ajp.mums.ac.ir/article_19491.html L1 - https://ajp.mums.ac.ir/article_19491_fccc900f7f81805431f5e95a60c2715d.pdf ER -