TY - JOUR ID - 18113 TI - Gastroprotective effect of Berberis vulgaris on ethanol-induced gastric mucosal injury: Histopathological evaluations JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Kapitonova, Marina AU - Gupalo, Sergey AU - Alyautdin, Renad AU - Ibrahim, Ibrahim Abdel Aziz AU - Salim, Norita AU - Ahmad, Azhar AU - Talip, Saiful Bahri AU - Nwe, Tin Moe AU - Morokhina, Svetlana AD - Faculty of Medicine and Health Sciences, UNIMAS, Kota Samarahan, Sarawak, Malaysia AD - Faculty of Medicine MAHSA University, Bandar Saujana Putra, Jenjarom, Selangor, Malaysia AD - Medicinal Products Safety, Scientific Centre for Expert Evaluation of Medicinal Products, Moscow, Russia. Department of Pharmacology, Sechenov University, Moscow, Russia AD - Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia AD - Institute of Medical Molecular Biotechnology, and Faculty of Medicine, UiTM, Sungai Buloh, Selangor, Malaysia AD - Department of Pharmacognosy, Sechenov University, Moscow, Russia Y1 - 2022 PY - 2022 VL - 12 IS - 1 SP - 30 EP - 41 KW - Berberis vulgaris KW - Stomach ulcer KW - Prostaglandin E2 DO - 10.22038/ajp.2021.18113 N2 - Objective: Modern treatment of peptic ulcers includes antibacterial and gastroprotective medications. However, current anti-ulcer drugs possess severe side effects. Therefore, all attempts to find new effective medications free from side effects are justified. Though Berberis vulgaris is a medicinal plant commonly used for the treatment of numerous disorders, gastroprotective effect of its leaf extract was not investigated before.Materials and Methods: Gastric ulcer was modelled in Sprague-Dawley rats after treatment with B. vulgaris leaf extract containing 0.07% of alkaloids, 0.48% of flavonoids and 8.05% of tanning substances, 10 or 50 mg of dry extract/kg, changes in the stomach mucosa were assessed semi-quantitatively, and the gastric wall was evaluated for prostaglandin E2 level using ELISA and assessed histologically by calculation of the lesion index.Results: B. vulgaris leaf extract at the dose of 50 mg/kg reduced the macroscopic ulcer score and the microscopic lesion index, increased prostaglandin E2 concentration in the gastric wall significantly higher than atropine and B. vulgaris leaf extract 10 mg/kg.Conclusion: The gastroprotective effect of the high dose of B. vulgaris leaf extract may be due to stimulation of prostaglandin E2 secretion in the stomach, and anti-oxidative and anti-inflammatory properties of polyphenolic complex of flavonoids and tannins present in the leaves of this plant. UR - https://ajp.mums.ac.ir/article_18113.html L1 - https://ajp.mums.ac.ir/article_18113_5deff6517b27b067ababa526230b69f5.pdf ER -