TY - JOUR ID - 16821 TI - Topical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healing JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Dias, Fernanda Gosuen Gonçalves AU - Pereira, Lucas de Freitas AU - Furtado, Ricardo Andrade AU - Magalhães, Geórgia Modé AU - Miguel, Marina Pacheco AU - Dias, Luis Gustavo Gosuen Gonçalves AU - Jorge, Adriana Torrecilhas AU - Honsho, Cristiane dos Santos AU - Ambrósio, Sérgio Ricardo AU - Bastos, Jairo Kenupp AU - Carrijo, Micaela Silva AU - Tavares, Denise Crispim AD - Department of Veterinary Medicine, Universidade de Franca, Franca (SP), Brazil AD - Department of Veterinary Medicine, Instituto Federal do Sul de Minas Gerais, Muzambinho (MG), Brazil AD - Department of Veterinary Medicine, Universidade Federal de Goiás, Goiânia (GO), Brazil AD - Department of Veterinary Medicine, Universidade Estadual Paulista, Jaboticabal (SP), Brazil AD - Department of Sciences, Universidade de Franca, Franca (SP), Brazil AD - Department of Pharmacy, Universidade de São Paulo, Ribeirão Preto (SP), Brazil Y1 - 2021 PY - 2021 VL - 11 IS - 2 SP - 120 EP - 133 KW - Cutaneous wound healing KW - Copaifera duckei Dwyer oleoresin KW - Toxicity DO - 10.22038/ajp.2020.16821 N2 - Objective: Evaluation of the healing and toxicological effects of Copaifera duckei Dwyer oleoresin (CDO).Materials and Methods: Rodents with skin lesions were divided into nine groups, including daily treatments with 1, 3 and 10% CDO, collagenase, antibiotic ointment and control groups, for 14 days.Results: Treatment with 10% CDO reduced skin edema and hyperplasia, demonstrating anti-inflammatory effect of the oil. Reduction in the wound area was observed, indicating the healing effect of CDO. Histopathological analysis showed increases in angiogenesis and re-epithelialization in animals treated with the highest concentration. On the other hand, no alterations in ulcerations, inflammatory infiltrate, hemorrhage, congestion, degeneration, percentage of collagen fibers, number of cells stained with anti-macrophage migration inhibitory factor, or density of area stained with anti-collagen I and III were found. Toxicogenetic analysis revealed no differences in micronucleus frequencies or in the ratio of polychromatic erythrocytes to total erythrocytes between treated and negative control, demonstrating the absence of genotoxicity and cytotoxicity, respectively. There was no difference in levels of liver enzymes among groups, indicating the absence of hepatotoxicity.Conclusion: Formulations of CDO exerted beneficial effects on the stages of cutaneous wound healing and are promising options for the treatment of wounds.  UR - https://ajp.mums.ac.ir/article_16821.html L1 - https://ajp.mums.ac.ir/article_16821_22533dd98ea5cf2a88760b8e27972c43.pdf ER -