TY - JOUR ID - 15622 TI - Phytochemical, anti-inflammatory and analgesic properties of stembark extract and fractions of Lonchocarpus sericeus Poir. (Papilionaceae) in albino mice JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - UDO, Uwemedimo Emmanuel AU - ECHEME, Johnbull Onyekachi AU - IGWE, Okenwa Uchenna AD - Department of Chemistry, Faculty of Science, University of Uyo, Uyo, Nigeria AD - Department of Chemistry, College of Physical and Applied Sciences,Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria. AD - Department of Chemistry, College of Physical and Applied Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria Y1 - 2020 PY - 2020 VL - 10 IS - 6 SP - 584 EP - 593 KW - Analgesia KW - Inflammation KW - Lonchocarpus sericeus KW - Phytochemicals DO - 10.22038/ajp.2020.15622 N2 - Objective: Lonchocarpus sericeusstembark decoction has been extensively employed in folkloric medicine in many parts of Nigeria as a remedy for pain as well as inflammation. The plant was studied for its anti-inflammatory as well as analgesic potency using standard biological models. Materials and Methods: The stembark of L. sericeus was evaluated for anti-inflammatory properties using egg albumin and xylene-induced oedema models. The pain-relieving property was evaluated using acetic acid-induced writhing and thermally-induced pain models. Median lethal dose determination (intraperitoneal LD50), quantification of some phytochemicals as well as phytochemical screening were also performed. Results: The LD50 of stembark extract of L. sericeus was found to be 3,100 mg/kg (i. p). The crude extract and fractions (310-930 mg/kg) effectively reduced oedema caused by egg albumin and xylene and exhibited high analgesic properties in inhibiting pain induced by acetic acid and heat. These reductions were dose-dependent and statistically significant (p <0.05-0.001) when compared to distilled water and similar to prototype drugs employed. Quantitative determinations of some bio-active constituents of the plant showed a higher flavonoid content (0.52±0.02 mg/100 g) compared to alkaloids (0.36±0.02 mg/100 g) and flavonoids (0.49±0.03 mg/100 g). Phytochemical screening of the stembark showed the presence of alkaloids, cardiac glycosides, flavonoids terpenes, tannins and saponins. Conclusion: These  results  imply  that  the stembark  extract  of L. sericeus  possesses anti-inflammatory  and analgesic potency and these data validate its  wide use  in folkloric medicine for inflammation and pain management. UR - https://ajp.mums.ac.ir/article_15622.html L1 - https://ajp.mums.ac.ir/article_15622_8207bd31f637a49b83fb1ba7c323ceb6.pdf ER -