TY - JOUR ID - 14644 TI - Glucose-lowering potential of Guiera senegalensis roots in a diabetic rat model JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Miaffo, David AU - Ntchapda, Fid&egrave;le AU - Guessom Kamgue, Oulianovie AU - Talba Abba, Mahamad AU - Kamanyi, Albert AD - Laboratory of Physiology, Department of Life and Earth Sciences, Higher Teachers’ Training College, University of Maroua. P.O. Box 55 Maroua, Cameroun AD - Department of Biological Sciences, Faculty of Science, University of Ngaound&eacute;r&eacute;, Ngaound&eacute;r&eacute;, Cameroon AD - Department of Animal Biology, University of Dschang, Dschang, Cameroon AD - Department of Biological Sciences, Faculty of Sciences, University of Maroua, Cameroon AD - Department of Animal Biology, Faculty of Science, Animal Physiology and Phytopharmacology Laboratory, University of Dschang, P.O. BOX 67, Dschang, Cameroon. Y1 - 2020 PY - 2020 VL - 10 IS - 6 SP - 653 EP - 663 KW - Guiera senegalensis KW - lipid profile KW - glycaemia KW - Diabetes Mellitus KW - phytochemical analysis DO - 10.22038/ajp.2020.14644 N2 - Objective: Guiera senegalensis is distributed in the Sudano-Sahelian zone and used traditionally for the treatment of diabetes. This study was designed to assess the hypoglycemic effects of G. senegalensis in Wistar diabetic rats. Materials and Methods: Phytochemical analysis was carried out on aqueous and methanolic extracts of G. senegalensis. Type 2 diabetes was induced in male rats using nicotinamide/streptozotocin (65 mg/kg/110 mg/kg, i.p.). After diabetes induction, normal and negative control groups received distilled water, positive control group received glibenclamide (0.25 mg/kg) and the others group received aqueous and methanolic extracts (200 and 400 mg/kg, each) orally for 4 weeks. Glycaemia, body weight, insulin level, total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), triglycerides (TG), aspartate amino transferase (AST) and alanine amino transferase (ALT) activities, urea and creatinine (Cr) were evaluated.  Results: The content of phenols, flavonoids and tannins were 34.54 mg gallic acid equivalent (GAE)/gE, 4.86 mg quercetin equivalent (QE)/gE and 16.81 mg catechin equivalent (EC)/gE in the aqueous extract, respectively. Phenol (26.01 mg GAE/gE), flavonoid (4.47 mg QE/gE) and tannin (7.67 mg EC/gE) contents were also obtained for the methanolic extract.  G. senegalensis and glibenclamide resulted in a significant increase (p <0.001) in body weight and HDL-c in diabetic group rats receiving glibenclamide and different doses of extracts. . The level of insulin, glycaemia, TG, TC, LDL-c, urea and creatinine significantly decreased (p G. senegalensis extracts. Conclusion: These results confirm the potential of G. senegalensis for the treatment of diabetes and its complications. UR - https://ajp.mums.ac.ir/article_14644.html L1 - https://ajp.mums.ac.ir/article_14644_726b9c77b24d8d69a03d83566310ef34.pdf ER -