TY - JOUR ID - 115 TI - Zataria multiflora Boiss inhibits muscarinic receptors of incubated tracheal smooth muscle with propranolol JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Jafari, Zahra AU - Boskabady, Mohammad Hossein AU - Pouraboli, Iran AU - Babazade, Beheshteh AD - Department of Physiology and Pharmaceutical Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran AD - Department of Biology, School of Sciences, Shahid Bahonar University, Kerman, I. R. Iran Y1 - 2011 PY - 2011 VL - 1 IS - 1 SP - 7 EP - 13 KW - Zataria multiflora Boiss KW - Labiatae KW - Methacholine KW - Anti cholinergic effect KW - Trachea KW - Guinea pig DO - 10.22038/ajp.2011.115 N2 - Objective(s): In the present study, the effect of tissue incubation with propranolol on functional antagonism of Zataria multiflora Boiss (Z. multiflora) at muscarinic receptors of tracheal smooth muscle was examined.  Materials and Methods: The effects of three concentrations of aqueous-ethanolic extract, 10 nM atropine, and saline on muscarinic receptors were tested on incubated tracheal smooth muscle with propranolol (n=5). Results: The EC50 of all concentration of the extract and atropine was significantly higher than that of saline. There was parallel right ward shift in concentration response curves obtained in the presence of all concentrations of the extract. There was not any significant difference in the maximum response and slope obtained in the presence of different concentrations of extract compared to saline. There was significant positive correlation between the concentrations and the values of EC50 (p<0.001). The value of (CR-1) obtained in the presence of highest concentration of the extract was significantly higher than that of atropine (p<0.05). Conclusion: These results indicated that functional antagonism of Z. multiflora at muscarinic receptors of tracheal smooth muscle was mainly due to b-adrenoceptor stimulatory effect of plant.   UR - https://ajp.mums.ac.ir/article_115.html L1 - https://ajp.mums.ac.ir/article_115_a4f4f7eb60a2ea07c7dc33bb89b7b381.pdf ER -