Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
7
6
2017
11
01
The effect of Saqez (Pistacia atlantica) ointment on nipple fissure improvement in breastfeeding women during one-month follow-up
477
485
EN
Nayereh
Asadi
Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
nayereh.asadi62@gmail.com
Nourossadat
Kariman
Research Center for Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
n_kariman@yahoo.com
Faraz
Mojab
0000-0003-2415-2175
Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
sfmojab@sbmu.ac.ir
Mohammad Amin
Pourhoseingholi
Liver Department, Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran
amin_phg@yahoo.com
10.22038/ajp.2017.22182.1827
Objective: Painful nipple fissure is a troublesome problem for breastfeeding mothers. This study was conducted to evaluate the effect of saqez (Pistacia atlantica) ointment on the improvement of nipple fissure in breastfeeding women during one-month follow-up.<br /> Materials and Methods: This randomized controlled clinical trial was conducted on 100 eligible women who visited the selected health centers affiliated to Shahid Beheshti University of Medical Sciences, Tehran, Iran, from July 2015 to December 2015 during their postpartum period. A total of 100 subjects were randomly divided into two equal groups of 50 women grouped as saqez ointment group and breast milk group, and followed-up for one month. Both groups received face-to-face instructions on breastfeeding techniques. For severity of nipple fissure, Storr scale and to measure the intensity of pain, visual analog scale (VAS) were used.<br /> Results: The results showed that the two groups were matched in terms of demographic and obstetric characteristics. Mean of nipple fissure severity in ointment group (42.62) was lower than that of the control group (48.02), that was significantly different between the two groups (p=0.047). In addition, Mean nipple pain intensity in ointment group (40.57) was lower than that of the control group (49.81), but there was no significant difference between the two groups (p=0.056).<br /> Conclusion: The present study showed that saqez ointment was more effective than breast milk in healing and controlling nipple fissures during one-month follow-up, without resulting in any side effects.
Nipple fissure,Pain,sagez ointment,Pistacia atlantica,Breast milk
https://ajp.mums.ac.ir/article_9336.html
https://ajp.mums.ac.ir/article_9336_28aea4a7ec0c1a91ebedf2935d687b58.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
7
6
2017
11
01
A review on botanicals with wound healing activity for pemphigus vulgaris: perspective of traditional Persian medicine and conventional medicine
486
494
EN
Fatemeh
Atarzadeh
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
dr.atarzadeh@gmail.com
Amir Mohammad
Jaladat
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
drjaladat@gmail.com
Babak
Daneshfard
0000-0001-6729-9113
Essence of Parsiyan Wisdom Institute, Phytopharmaceutical Technology and Traditional Medicine Incubator, Shiraz University of Medical Sciences, Shiraz, Iran
babakdaneshfard@gmail.com
Ladan
Dastgheib
Shiraz Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran
dastgheibl@sums.ac.ir
Mohammad
Kamalinejad
0009-0006-6373-1320
Department of Pharmacognosy, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
mkamalinejad@yahoo.com
Gholamreza
Amin
Department of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
amin@sina.tums.ac.ir
10.22038/ajp.2017.17889.1695
<strong>Objective:</strong> As a rare autoimmune disease, pemphigus vulgaris has a poor prognosis especially in lack of proper medical support. This blistering disease involves both the skin and mucus membranes. The challenge is improving the healing process of skin lesions of which, superimposed infections are among the main causes of the disease mortality. Accordingly, we aimed to assess the treatment options suggested by traditional Persian medicine (TPM) and compare them with current findings.<br /> <strong>Materials and Methods:</strong> We studied the main clinical and pharmaceutical textbooks of TPM (Kitāb al-hāwīfī al-tibb, the Canon of Medicine, Eksir-e-Aazam, Tuhfat al-mu'minīn, Makhzan al-adviyah (focusing on the skin chapter and respective herbal remedies for the inflamed skin and ulcers. Additionally, scientific databases such as PubMed, Science direct, Scopus, and Google Scholar were searched for the current pharmacological evidence. In the studied books, the term “hot ulcers” was found close to what is known as “Pemphigus vulgaris”.<br /> <strong>Results:</strong> Reported medicinal herbs possess anti-inflammatory, antioxidant, wound healing, and antibacterial activities reported by recent studies. Therefore, they could be introduced as novel natural remedies for pemphigoid wounds.<br /> <strong>Conclusion:</strong> Taken as a whole, the review of traditional remedies for hot ulcers in Persian medical and pharmaceutical literature may open a new window toward developing new topical treatments for this disease.
Pemphigus vulgaris,Traditional Persian Medicine,Herbal remedies
https://ajp.mums.ac.ir/article_8261.html
https://ajp.mums.ac.ir/article_8261_d29eea9e3b30e5040af2ef15d3b55269.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
7
6
2017
11
01
Effects of Musa sapientum stem extract on experimental models of anxiety
495
501
EN
Aditya
Jielella Reddy
Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India
adityareddy.jilella@gmail.com
Ashok
Kumar Dubey
Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India
ak.dubey@sharda.ac.in
Shailendra
Handu
Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India
shailendra.handu@sharda.ac.in
Sachin
Manocha
Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India
sachin.manocha@sharda.ac.in
Pramod
Kumari Mediratta
Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India
pramod.kumari@shrada.ac.in
Qazi
Ahmed Mushtaq
Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India
qm.ahmed@sharda.ac.in
10.22038/ajp.2017.8822
Objective: The Musa sapientum (banana) plant extract has shown antioxidant activity in previous studies. Oxidative stress is one of the important factors implicated in the pathogenesis of anxiety disorders. The present study aimed to evaluate the anxiolytic activity of aqueous extract of M. sapientum stem (MSSE) in experimental models in mice.<br /> Material and Methods: Elevated Plus Maze method and locomotor monitoring by photoactometer were used. Animals were divided into five different groups (n=6/group). The vehicle, standard and the experimental groups were given distilled water (10 ml/kg), diazepam (1 mg /kg intraperitoneally) and incremental doses of 25, 50 and 100 mg/kg of MSSE, respectively, prior to the experiment. The standard group received diazepam.<br /> Results: The number of open arm entries and the duration of time spent in the open arms in the MSSE-treated groups increased significantly in a dose-dependent manner as compared to that of control group. The duration of time spent in closed arms in the MSSE-treated groups decreased significantly in a dose-dependent manner as compared to that of the control group. MSSE also decreased the locomotor activity significantly at all three test doses.<br /> Conclusion: The results of this study suggest an anxiolytic activity for MSSE, which make it a potential natural compound for treatment of anxiety disorders.
Musa sapientum,Anxiety,Oxidative stress,Elevated plus maze,Mice
https://ajp.mums.ac.ir/article_8822.html
https://ajp.mums.ac.ir/article_8822_0c9114227428ef9aac2a0bd6ec53fa63.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
7
6
2017
11
01
Thymoquinone restores liver fibrosis and improves oxidative stress status in a lipopolysaccharide-induced inflammation model in rats
502
510
EN
Fereshteh
Asgharzadeh
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
asgharzadehf931@mums.ac.ir
Rahimeh
Bargi
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
bargir931@mums.ac.ir
Farimah
Beheshti
0000-0003-1524-2339
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
beheshtif1@thums.ac.ir
Seyed Mahmoud
Hosseini
0000-0001-6425-5123
Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
hosseinim@mums.ac.ir
Mehdi
Farzadnia
Departments of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
farzadniam@mums.ac.ir
Majid
Khazaei
0000-0002-5247-4043
Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
khazaeim@mums.ac.ir
10.22038/ajp.2017.21744.1815
Objective: Liver fibrosis is the primary sign of chronic liver injury induced by various causes. Thymoquinone (TQ) is the major ingredient of Nigella sativa with several beneficial effects on the body. In the present study, we aimed to investigate the effect of TQ on liver fibrosis in a lipopolysaccharide (LPS)-induced inflammation in male rats.<br /> Materials and methods: Fifty male Wistar rats were randomly divided into five groups (n=10 in each group) as follow: (1) control; (2) LPS (1 mg/kg/day; i.p); (3) LPS+TQ 2 mg/kg/day (i.p) (LPs+TQ2); (4) LPS+TQ 5 mg/kg/day (LPS+TQ5); (5) LPS+ TQ 10 mg/kg/day (LPS+ TQ10). After three weeks, blood samples were taken for evaluation of liver function tests. Then, the livers were harvested for histological evaluation of fibrosis and collagen content and measurement of oxidative stress markers including malondialdehyde (MDA), total thiol groups, superoxide dismutase (SOD) and catalase activity in tissue homogenates.<br /> Results: LPS group showed higher levels of fibrosis and collagen content stained by Masson’s trichrome in liver tissue with impaired liver function test and increased oxidative stress markers (p<0.05). Treatment by TQ restored liver fibrosis, improved liver function tests and increased the levels of anti-oxidative enzymes (SOD and catalase), while reduced MDA concentration (p<0.05).<br /> Conclusion: Treatment by TQ restores inflammation-induced liver fibrosis possibly through affecting oxidative stress status. It seems that administration of TQ can be considered as a part of liver fibrosis management.
Inflammation,Thymoquinone,Liver,Fibrosis
https://ajp.mums.ac.ir/article_8932.html
https://ajp.mums.ac.ir/article_8932_d99f0126132ab630157206dbbc8e15db.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
7
6
2017
11
01
The effect of hydro-alcoholic of Phoenix Dactylifera extract on sleep and EEG in rat
511
518
EN
Sahar
Rahimi
Department of Physiology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
rahimi.8844@yahoo.com
Hojjatollah
Alaie
Department of Physiology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
alaei@med.mui.ac.ir
Parham
Reisi
Department of Physiology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
p_reisi@med.mui.ac.ir
Zahra
Siahmard
Department of Physiology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
pagrom_qeshm@yahoo.com
Behzad
Zolfaghari
0000-0001-7087-2590
Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Science, Isfahan, Iran
behzadz@gmail.com
Aliasghar
Pourshanazari
Department of Physiology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
dagh_sabz@yahoo.com
10.22038/ajp.2017.12730.1522
Objective: Hard envelope of date palm pollen is used as a sedative and calmative compounds in Iranian traditional medicine. We tried to study the effects of Phoenix dactylifera (Tarooneh) extract on sleep time and Brian waves.<br /> Materials and Methods: Rats were divided into control and test groups in sleep experiment. Control groups included intact group (without any injection), negative control group (saline) and positive control group (midazolam 0.1 mg/kg). Test groups received three doses of Tarooneh extract (62.5, 125 and 250 mg/kg). Rat were placed in sleep physiograph system and recording started 20 min after 2-hr calming down. Four parameters including sleep time, awakening, most activity period and main sleep time interval were measured. In EEG experiment electrodes were placed under the cranium for EEG recording and waves were compared with their baselines.<br /> Results: All doses of the extract increased sleeping time (p< 0.05) but just the dose of 250 mg/kg (p<0.05) and midazolam (p< 0.001) decreased the awakening time. EEG results showed that the dose of 125 mg/kg increased the low frequency waves (p< 0.05) and the dose of 250 mg/kg decreased high frequency waves of alpha and beta (p< 0.05).<br /> Conclusion: Due to these effect on sleeping time and EEG, Tarooneh extract consumption can be useful as a sedative agent in Iranian traditional medicine. According to this study, the doses of 125 and 250 mg/kg of the extract would be the appropriate doses to be further studied.
insomnia,Sleep,EEG,Tarooneh
https://ajp.mums.ac.ir/article_9055.html
https://ajp.mums.ac.ir/article_9055_66f204dae6ccbe0b147a1b54662a15a2.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
7
6
2017
11
01
In vitro and in vivo effects of Peganum harmala L. seeds extract against influenza A virus
519
530
EN
Mohammad-Taghi
Moradi
0000-0002-3103-3740
Students Research Committee, Medical Plants Research Center, Shahrekord University of Medical Science, Shahrekord, Iran
mtmoradi65@gmail.com
Ali
Karimi
0000-0003-1554-3668
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
kakarimi42@gmail.com
Fatemeh
Fotouhi
Department of Influenza and other Respiratory Viruses, Pasteur Institute of Iran, Tehran, Iran
fotouhi@pasteur.ac.ir
Soleiman
Kheiri
Department of Epidemiology and Biostatistics, Shahrekord University of Medical Sciences, Shahrekord, Iran
mtmoradi51@gmail.com
Ali
Torabi
Department of Influenza and other Respiratory Viruses, Pasteur Institute of Iran, Tehran, Iran
alitorabi@pasteur.ac.ir
10.22038/ajp.2017.22265.1830
Objective: Influenza A virus infections are still a major health problem and the choices available for the control and treatment of the disease are limited. This research evaluated in vitro and in vivo antiviral effects of Peganum harmala L. seeds (PHS) extract against influenza A virus.<br /> Materials and Methods: In this research, in vitro anti-influenza A virus activity of the extract was assessed in Madin-Darby canine kidney (MDCK) cells. In order to evaluate anti-influenza activity of PHS extract in vivo, BALB/c mice were infected with 5LD<sub>50</sub> of mouse-adapted influenza virus (H1N1; PR8) and received 200 mg/kg/day of PHS extract or 20 mg/kg/day oseltamivir. Lungs of seven mice per group were removed on day 3 post-infection and lung virus titers were determined by qRT-PCR. Mice survival, body weights and general conditions were observed for up to 14 days post-infection.<br /> Results: The results demonstrated that, the ethanolic extract of PHS possesses high activity against influenza virus with IC<sub>50</sub> value of 15.7 (CI95%:11.7-21) μg/ml in MDCK cells. Our results also showed that, oral administration of PHS extract (200 mg/kg/day) or oseltamivir (20 mg/kg/day) to infected mice, increased the survival rate, reduced body weight loss, and decreased lung virus titer.<br /> Conclusion: Based on our findings, P. harmala seeds extract can inhibit influenza A virus replication in vitro and in vivo. Therefore, isolation and characterization of the plant’s active compounds and investigation of the underlying mechanisms of its antiviral action are highly suggested.
Influenza A virus,Antiviral activity,Peganum harmala L
https://ajp.mums.ac.ir/article_9060.html
https://ajp.mums.ac.ir/article_9060_8c85287ee87c018b0e0d0c74f53ba5c0.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
7
6
2017
11
01
The effect of Zataria multiflora and carvacrol on wheezing, FEV1 and plasma levels of nitrite in asthmatic patients
531
541
EN
Azam
Alavinezhad
Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
alavina901@mums.ac.ir
Mahdiyeh
Hedayati
Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
hedayatim912@mums.ac.ir
Mohammad Hossein
Boskabady
0000-0001-5736-9755
Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
boskabadymh@mums.ac.ir
10.22038/ajp.2017.24102.1883
Objective: The preventive effect of Zataria multiflora in animal models of asthma has been reported. In the present study, its effect on wheezing, forced expiratory volume in 1 second, and plasma nitrite (NO<sup>2-</sup>) in asthmatic patients was studied.<br /> Materials and Methods: In this study, forty asthmatic patients including 15 males and 25 females (aged 45.8±6.21 years) were randomly allocated in four groups including placebo group (P), and three treatment groups which received two doses of Z. multiflora (groups Z low and Z high that received 5 and 10 mg/kg/day, respectively) and carvacrol (group C treated with 1.2 mg/kg/day). All patients were treated for two months in a double-blind manner. At three time points (before starting the treatment (pretreatment), and one and two month after treatment), wheezing during day and exercise, forced expiratory volume in 1 second and NO<sup>2-</sup> were measured.<br /> Results: Day wheeze and exercise wheeze were significantly reduced in treated groups with carvacrol and both doses of Z. multiflora compared to pretreatment (p1% was significantly increased in treated groups with carvacrol and both doses of Z. multiflora (p2- was also significantly decreased in Z high and carvacrol groups after two months of treatment (p Conclusion: Z. multiflora and its constituent, carvacrol, improved FEV<sub>1</sub>% while reduced wheezing and plasma level of NO<sup>2-</sup> in asthmatic patients. Therefore, a possible therapeutic potential for this plant and its constituent, carvacrol could be suggested to be used against asthma.
Asthma,Zataria multiflora,Carvacrol,Forced expiratory volume in one second,Wheezing,Nitrite
https://ajp.mums.ac.ir/article_9099.html
https://ajp.mums.ac.ir/article_9099_6448cf37376be1b5a6ab620772e25943.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
7
6
2017
11
01
The protective effect of hydroalcoholic extract of Ginger (Zingiber officinale Rosc.) against iron-induced functional and histological damages in rat liver and kidney
542
553
EN
Firouzeh
Gholampour
Department of Biology, School of Sciences, Shiraz University, Shiraz, Iran
gholampour@shirazu.ac.ir
Fatemeh
Behzadi Ghiasabadi
Department of Biology, School of Sciences, Shiraz University, Shiraz, Iran
frzhgholampour@yahoo.com
Seyed Mohammad
Owji
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
smowji@yahoo.com
Jaafar
Vatanparast
Department of Biology, School of Sciences, Shiraz University, Shiraz, Iran
jafarvatanparast@gmai.com
10.22038/ajp.2017.22297.1831
Objective: Iron overload in the body is related with toxic effects and threatens the health. The aim of this study was to evaluate the protective role of hydroalcoholic extract of ginger (Zingiber officinale) against ferrous sulfate-induced hepatic and renal functional disorders and histological damages in rats.<br /> Materials and Methods: The rats were divided into four groups (n=7): Sham, Sham + G.E (ginger extract, 400 mg/kg/day for 14 days), FS (ferrous sulfate, 30 mg/kg/day for 14 days), FS+G.E (ferrous sulfate, 30 mg/kg/day for 14 days; ginger extract, 400 mg/kg/day for 11 days from the fourth day of ferrous sulfate injection). After 24 hr, blood, urine and tissue samples were collected.<br /> Results: Compared with Sham and Sham + G.E groups, administration of ferrous sulfate resulted in liver and kidney dysfunction as evidenced by significantly higher levels of serum hepatic markers and bilirubin, and lower levels of serum albumin, total protein, triglyceride, cholesterol and glucose, as well as lower creatinine clearance and higher fractional excretion of sodium (p<0.001). This was accompanied by increased malondialdehyde levels and histological damages (p<0.001). In the FS + G.E, ginger extract significantly (p<0.01) reversed the levels of serum hepatic markers, renal functional markers and lipid peroxidation marker. Furthermore, it restored the levels of serum total protein, albumin, glucose, triglycerides and cholesterol and decreased bilirubin concentration in the blood. All these changes were corroborated by histological observations of liver and kidney.<br /> Conclusion: In conclusion, ginger extract appears to exert protective effects against ferrous sulfate-induced hepatic and renal toxicity by reducing lipid peroxidation and chelating iron.
Albumin,Ferrous sulfate,Kidney,Lipid Peroxidation,Liver,Zingiber officinale
https://ajp.mums.ac.ir/article_9113.html
https://ajp.mums.ac.ir/article_9113_aa5b6d082c2ea61eda154515969892d7.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
7
6
2017
11
01
Effect of Apium graveolens and Trachyspermum copticom on clinical symptoms of patients with functional dyspepsia
554
564
EN
Maryam
Azimi
Department of Traditional Medicine, School of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran
dr.azim@gmail.com
Mohammad Javad
Zahedi
Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran
zahedimj@yahoo.com
Mitra
Mehrabani
Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran
mmehrabani@hotmail.com
Haleh
Tajadini
Department of Traditional Medicine, School of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran
dr_haleh@yahoo.com
Farzaneh
Zolala
Associate Professor of Biostatistics Modeling in Health Research Center Institute for Futures Studies in Health Kerman University of Medical Sciences, Kerman, Iran
zolalafarzaneh@gmail.com
Mohammad
Baneshi
Biostatistics and Epidemiology Department, Modeling in Health Research Center, Institute for Futures Studies in Health Kerman University of Medical Sciences, Kerman, Iran
rbaneshi@gmail.com
Rasool
Choopani
Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
rchoopani@hotmail.com
Fariba
Sharififar
Herbal and Traditional Medicines Center, Kerman University of Medical Science, Kerman, Iran
fsharififar@kmu.ac.ir
Ali
Asadipour
Herbal and Traditional Medicines Center, Kerman University of Medical Science, Kerman, Iran
aliasadipour@yahoo.com
Mohammad
Hayatbakhsh
Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran
m24672@yahoo.com
Bijan
Ahmadi
Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran
ay-bijan@yahoo.com
10.22038/ajp.2017.20630.1786
Objectives:This study aimed at investigating the effect of Iranian traditional remedy prepared from Apium graveolens and Trachyspermum copticom (AT) on the severity and frequency of symptoms in patients with functional dyspepsia (FD).<br /> Material and Methods:In total, 150 FD patients were included in this randomized double-blind trial, based on the ROME III diagnostic criteria, and they were divided into three intervention groups namely, AT, Placebo and omeprazole. Then, severity and frequency of symptoms during this eight-week trial were measured. Obtained information was analyzed using Chi-square test and repeated measures test.<br /> Result:In general, the severity and frequency of symptoms after the 4th week significantly decreased in the AT group as compared to the omeprazole and placebo groups, and continued to reduce by the end of the eighth week. General reduction of symptom severity and frequency in the omeprazole group was significantly different from the placebo group by the end of the 4th and 8th weeks. With respect to each individual symptom, AT markedly improved symptoms, such as burning, pain, early satiation, fullness, bloating, belching and nausea, as compared to placebo-treated group. Moreover, AT significantly improved symptoms, like vomiting, and nausea, except for pain, as compared to omeprazole-treated subjects.<br /> Conclusion:According to the results, AT, as Iranian traditional remedy, was more effective than omeprazole and placebo in reducing the symptoms in FD patients.
IranianTraditional medicine,Apium Graveolens,Trachyspermum Copticom,Functional Dyspepsia
https://ajp.mums.ac.ir/article_9131.html
https://ajp.mums.ac.ir/article_9131_e201cea3de0f63f9d6899c46fda920d1.pdf