ORIGINAL_ARTICLE
Black henbane and its toxicity – a descriptive review
Black henbane (BH) or Hyoscyamus niger, has been used as a medicine since last centuries and has been described in all traditional medicines. It applies as a herbal medicine, but may induce intoxication accidentally or intentionally. All part of BH including leaves, seeds and roots contain some alkaloids such as Hyoscyamine, Atropine, Tropane and Scopolamine. BH has pharmacological effects like bronchodilating, antisecretory, urinary bladder relaxant, spasmolytic, hypnotic, hallucinogenic, pupil dilating, sedative and anti-diarrheal properties. Clinical manifestations of acute BH poisoning are very wide which include mydriasis, tachycardia, arrhythmia, agitation, convulsion and coma, dry mouth, thirst, slurred speech, difficulty speaking, dysphagia, warm flushed skin, pyrexia, nausea, vomiting, headache, blurred vision and photophobia, urinary retention, distension of the bladder, drowsiness, hyper reflexia, auditory, visual or tactile hallucinations, confusion, disorientation, delirium, aggressiveness, and combative behavior. The main treatment of BH intoxicated patients is supportive therapies including gastric emptying (not by Ipecac), administration of activated charcoal and benzodiazepines. Health care providers and physicians particularly emergency physicians and clinical toxicologists should know the nature, medical uses, clinical features, diagnosis and management of BH poisoning.
https://ajp.mums.ac.ir/article_3187_9fea6ca64012de61ba4898272e8c3b65.pdf
2014-09-01
297
311
10.22038/ajp.2014.3187
Black henbane
Hyoscyamus niger
Anticholinergic
Benzodiazepine
Poisoning
Physostigmine
Atropine
Hyoscyamine
Anahita
Alizadeh
Alizadehan@mums.ac.ir
1
Pediatrician- Fellowship of clinical Toxicology Imam Reza Hospital, Mashhad University of Medical Science, Mashhad, I. R. Iran
AUTHOR
Mohammad
Moshiri
2
Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Science, Mashhad, I. R. Iran
AUTHOR
Javad
Alizadeh
3
Mechanical Engineer, Hydro mechanical designer BS, Department of Dam and hydropower plant Hydromechanics of Tooss Ab Company, Mashhad, I. R. Iran
AUTHOR
Mahdi
Balali Mood
balalimoodm@mums.ac.ir
4
Medical Toxicology Research Centre, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
LEAD_AUTHOR
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ORIGINAL_ARTICLE
Protective effect of Petroselinum crispum extract in abortion using prostadin-induced renal dysfunction in female rats
Objective: Present study investigated the effects of parsley extract on pregnant rat kidneys which have undergone clinical abortion using prostaglandins. The renal protective effect of parsley extract was evaluated in pregnant rats which had an abortion. Parsley was used due to its antioxidant properties. Materials and Methods: Fifty-four female rats were divided in 9 groups of 6: control pregnant, two pregnant groups which received parsley extract and prostadin, two non-pregnant groups treated with parsley extract and prostadin, a group administered with both treatments, and three groups which received parsley extract in pre-implantation, implantation, and post-implantation periods of embryos. Ethanolic extract (5 mg/kg) was given daily to animals for 18 days of pregnancy period. Parameters such as malondialdehyde (MDA), total antioxidant statues (TAS), creatinine, and urea were measured using biochemical assays. Histopathologic studies were also done with Hematoxylin-Eosin staining method. Results: After 18 days of treatment, significant differences were observed in serum creatinine, urea, and MDA and TAS levels. Kidney cross-sections showed edema in prostadin-treated rats while improvements in parsley + prostadin -treated rats were observed. Conclusion: These results suggested that ethanolic extract of Petroselinum crispum reduced the dysfunction in rats kidney caused by prostadin-induced abortion and could have beneficial effect in reducing the progression of prostaglandin-induced edema.
https://ajp.mums.ac.ir/article_2318_8ac79437198cf5ba3c5dd2511b7ca1ee.pdf
2014-09-01
312
319
10.22038/ajp.2014.2318
Abortion
Dysfunction
Kidney
Petroselinum crispum
Maryam
Rezazad
fereshtesb@yahoo.com
1
Department of Biology, Urmia University, Urmia, I.R.Iran
AUTHOR
Farah
Farokhi
f.farokhi@urmia.ac.ir
2
Department of Biology, Urmia University, Urmia, I.R.Iran
LEAD_AUTHOR
Alderson NL, Chachich ME, Frizzell N, Canning P, Metz TO et al. 2004. Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in streptozotocin diabetic rat. Diabetologia, 47: 1385-1395.
1
Al-Howiniry T, Al-Sohaibani M, El-Tahir K, Rafatullah S. 2003. Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "parsley", Petroselinum crispum. Am J Chim Med, 31: 699-711.
2
Ashraf H, Heidari R, Nejati V, Ilkhanipoor M. 2013. Aqueous extract of Berberis integerrima root improves renal dysfunction in streptozotocin induced diabetic rats. Avicenna J Phytomed, 3: 82-90
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16
Sener GK, Sacan O, Yanardag R, Ayanoglu-Du Lger G.L. 2003. Effects of Parsley (Petroselinum crispum) on the Aorta and Heart of Stz Induced Diabetic Rats, P Foods Hum Nut 58: 1-7.
17
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Spraul MH, Nitz S, Drawert F. 1991. The chemical composition of parsley root and seed extracts. Chem Microbial Tech lebensm, 13: 179-182.
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20
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21
Yanardag R, Bolkent S, Tabakoglu-Ogluz A, Ozoy-Sacan O. 2003. Effects of Petroselinum crispum extract on pancreatic B cells and blood glucose of streptozotocin-induced diabetic rats. Biol Pharm Bull 26: 1206-1210.
22
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23
ORIGINAL_ARTICLE
Evaluation of antibacterial and anthelmintic activities with total phenolic contents of Piper betel leaves
Objective: The study was conducted to investigate the antibacterial and anthelmintic activities and to determine total phenolic contents of methanolic extract of Piper betel leaves. Materials and Methods: The extract was subjected to assay for antibacterial activity using both gram positive and gram negative bacterial strains through disc diffusion method; anthelmintic activity with the determination of paralysis and death time using earthworm (Pheritima posthuma) at five different concentrations and the determination of total phenolic contents using the Folin-ciocalteau method. Results: The extract showed significant (p<0.01) zone of inhibitions against gram positive Staphylococcus aureus [(6.77±0.25) mm] and Gram negative Escherichia coli [(8.53±0.25) mm], Salmonella typhi [(5.20±0.26) mm], Shigella dysenteriae [(11.20±0.26) mm] compared to positive control Azithromycin (ranging from 20.10±0.17 to 25.20±0.35 mm) while no zone inhibitory activity was found for both the extract and the standard drug against Gram positive Bacillus cereus. The extract also showed potent anthelmintic activity requiring less time for paralysis and death compared to the standard drug albendazole (10 mg/ml). At concentrations 10, 20, 40, 60 and 80 mg/ml, leaves extract showed paralysis at mean time of 9.83±0.60, 8.50±0.29, 6.60±0.17, 6.20±0.44 and 4.16±0.60; death at 11.33±0.88, 9.67±0.33, 7.83±0.17, 7.16±0.60 and 5.16±0.72 minutes, respectively. Whereas the standard drug showed paralysis and death at 19.33±0.71 and 51.00±0.23 minutes respectively. The extract confirmed the higher concentration of phenolic contents (124.42±0.14 mg of GAE /g of extract) when screened for total phenolic compounds. Conclusion: Asresults confirmed potential antibacterial and anthelmintic activities of Piper betel leaves extract, therefore it may be processed for further drug research.
https://ajp.mums.ac.ir/article_2777_0d0d9a7c2b8b7bd216ecdb13c2890c40.pdf
2014-09-01
320
329
10.22038/ajp.2014.2777
Anthelmintic activity
Antibacterial activity
Leaf extract
Piper betel
Total phenolic contents
Kazi
Akter
nahidphar@gmail.com
1
Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814
AUTHOR
Palash
Karmakar
pknstu@gmail.com
2
Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh
LEAD_AUTHOR
Abhijit
Das
abhi.nstu@gmail.com
3
Department of Pharmacy, Noakhali Science and technology University, Sonapur, Noakhali-3814
AUTHOR
Shamima
Anonna
onu.bd87@yahoo.com
4
Department of Pharmacy, Noakhali Science and Technology university, Sonapur, Noakhali-3814
AUTHOR
Sharmin
Shoma
shoma.pharmnstu@gmail.com
5
Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814
AUTHOR
Mohammad
Sattar
maf@juniv.edu
6
Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh
AUTHOR
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49
ORIGINAL_ARTICLE
Hepatoprotective effect of Crocus sativus (saffron) petals extract against acetaminophen toxicity in male Wistar rats
Objectives: Acetaminophen (APAP) toxicity is known to be common and potentially fatal. This study aims to investigate the protective effects of hydroalcoholic extract, remaining from Crocus sativus petals (CSP) against APAP-induced hepatotoxicity by measuring the blood parameters and studying the histopathology of liver in male rats. Materials and Methods: Wister rats (24) were randomly assigned into four groups including: I) healthy, receiving normal saline; II) Intoxicated, receiving only APAP (600 mg/kg); III) pre-treated with low dose of CSP (10 mg /kg) and receiving APAP (600 mg/kg); IV) pre-treated with high dose of CSP (20 mg/kg) and receiving APAP (600 mg/kg). Results: The APAP treatment resulted in higher levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and bilirubin, along with lower total protein and albumin concentration than the control group. The administration of CSP with a dose of 20 mg/kg was found to result in lower levels of AST, ALT and bilirubin, with a significant higher concentration of total protein and albumin. The histopathological results regarding liver pathology, revealed sever conditions including cell swelling, severe inflammation and necrosis in APAP-exposed rats, which was quiet contrasting compared to the control group. The pre-treated rats with low doses of CSP showed hydropic degeneration with mild necrosis in centrilobular areas of the liver, while the same subjects with high doses of CSP appeared to have only mild hepatocyte degeneration. Conclusions: Doses of 20 mg/kg of CSP ameliorates APAP–induced acute liver injury in rats. It was concluded that the antioxidant property of CSP resulted in reducing the oxidative stress complications of toxic levels of APAP in intoxicated rats.
https://ajp.mums.ac.ir/article_3010_fdf4489f08a19667d77289658a54dba7.pdf
2014-09-01
330
336
10.22038/ajp.2014.3010
Acetaminophen (APAP)
Crocus sativus (CS)
Flowers
Hepatotoxicity
Rats
Arash
Omidi
aomidi@shirazu.ac.ir
1
Department of Animal Health Management, School of Veterinary Medicine, Shiraz University, I. R. Iran
LEAD_AUTHOR
Narges
Riahinia
narges_riahinai@yahoo.com
2
Department of Animal Sciences, Agriculture Faculty, Birjand University, Birjand, I. R. Iran
AUTHOR
Mohammad Bagher
Montazer Torbati
3
Department of Animal Sciences, Agriculture Faculty, Birjand University, Birjand, I. R. Iran
AUTHOR
Mohammad-Ali
Behdani
behdani_m@yahoo.com
4
Saffron Research Group, Birjand University, Birjand, I. R. Iran
AUTHOR
Abdullaev FI. 2002. Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.). Exp Biol Med, 227: 20-25.
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Arnaiz S. 1995. Oxidative stress by acute acetaminophen administration in mouse liver. Free Radical Bio Med, 19:303–310.
3
Azizi-Zohan A, Kamgar-Haghighi AA, Sepaskhah AR. 2008. Crop and pan coefficients for saffron in a semi-arid region of Iran. J Arid Environ, 72: 270–278.
4
Babaei A, Arshami J, Haghparast A, Daneshmesgharan M. 2014. Effects of saffron (Crocus sativus) petal ethanolic extract on hematology, antibody response, and spleen histology in rats. Avicenna J Phytomed, 4: 130-109.
5
Barle H, Hammarqvist F, Westman B, Klaude M, Rooyackers O, Garlick PJ, et al. 2006. Synthesis rates of total liver protein and albumin are both increased in patients with an acute inflammatory response. Clin sci, 110: 93–99.
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Bunchorntavakul C, Reddy KR. 2013. Acetaminophen-related Hepatotoxicity. Clin Liver Dis,17: 587–607.
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Goli SAH, Mokhtari F, Rahimmalek M. 2012. Phenolic Compounds and Antioxidant Activity from Saffron (Crocus sativus L.) Petal. J Agr Sci, 4: 175.
9
Hinson J, Roberts D, James L. 2010. Mechanisms of Acetaminophen-Induced Liver Necrosis. In: Uetrecht J, editor. Adverse Drug Reactions. vol. 196 of Handbook of Experimental Pharmacology. Berlin, Heidelberg: Springer Berlin Heidelberg. p. 369–405.
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Lu Y, Sun J, Petrova K, Yang X, Greenhaw J, Salminen WF, et al. 2013. Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice. Food Chem Ttoxicol, 62: 707–721.
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Melnyk JP, Wang S, Marcone MF. 2010. Chemical and biological properties of the world’s most expensive spice: Saffron. Food Res Int, 43: 1981–1989.
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Moshiri E, Basti AA, Noorbala AA, Jamshidi AH, Hesameddin Abbasi S, Akhondzadeh S. 2006. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: A double-blind, randomized and placebo-controlled trial. Phytomedicine, 13: 607–611.
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Nam KN, Park YM, Jung HJ, Lee JY, Min BD, Park SU, et al. 2010. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. Eur J Pharmacol, 648: 110–116.
18
Olaleye MT, Rocha BTJ. 2008. Acetaminophen-induced liver damage in mice: Effects of some medicinal plants on the oxidative defense system. Exp Toxicol Pathol, 59: 319–327.
19
Omidi A, Torabi Z, Hassanpoorfard M, Zardast M. 2013. Evaluation of protective effect of hydroalcoholic extract of Crocus sativus petals on preventing of gentamicin induced peliosishepatis and hepatic telangiectasis in rats: short communication. J Birjand Uni Med Scie, 19 : 455-462. [persian].
20
Pimple BP, Kadam PV, Badgujar NS, Bafna AR, Patil MJ. 2007. Protective effect of Tamarindus indica linn against paracetamol-induced hepatotoxicity in rats. Indian J Pharm Sci, 69: 827.
21
Poma A, Fontecchio G, Carlucci G, Chichiriccò G. 2012. Anti-inflammatory properties of drugs from saffron crocus. Antiinflamm Antiallergy Agents Med Chem, 11: 37–51.
22
Reitman S, Frankel SA. 1957. Chlorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvate transaminases. Am J Clin Pathol, 28: 56-63.
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Schmidt M, Betti G, Hensel A. 2007. Saffron in phytotherapy: Pharmacology and clinical uses. Wien Med Wochenschr, 157: 315–319
24
Shah AD, Wood DM, Dargan PI. 2011. Understanding lactic acidosis in paracetamol (acetaminophen) poisoning. British J Clin Pharmaco,71: 20–28.
25
Tamaddonfard E, Farshid AA, Maroufi S, Kazemi-Shojaei S, Erfanparast A, Asri-Rezaei S, et al. 2014. Effects of safranal, a constituent of saffron, and vitamin E on nerve functions and histopathology following crush injury of sciatic nerve in rats. Phytomedicine, 21: 717-723.
26
Tan SC, New LS, Chan ECY. 2008. Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine. Toxicol Lett, 180: 174–181.
27
Termentzi A, Kokkalou E. 2008. LC-DAD-MS (ESI+) analysis and antioxidant capacity of crocus sativus petal extracts. Planta Med, 74: 573–581.
28
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29
ORIGINAL_ARTICLE
Evaluating the effects of galbanic acid on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes
Objective: Ferula szowitsiana has been widely used for medicinal purposes around the world. The anti-oxidant effect of F.szowitsiana had been proved. The current study aims to determine the protective effects of galbanic acid, a sesquiterpene coumarin from F. szowitsiana, against hydrogen peroxide (H2O2) - induced oxidative DNA damage in human lymphocytes. Materials and Methods: Human lymphocytes were incubated with H2O2 (0, 25, 50, 100, and 200 µM), galbanic acid (200 and 400 µM) and a combination of galbanic acid (200 and 400 µM) and H2O2 (25 µM) at 4 C for 30 minutes. Solvents of galbanic acid without H2O2 were used as negative controls. Results: The findings of this study demonstrated that H2O2 exposure leads to a significant concentration-dependent increase in DNA damage. Galbanic acid did not cause DNA damage compared with the control cells. Data showed that galbanic acid does not have a protective effect against H2O2-induced oxidative DNA damage in human lymphocytes. Conclusion: According to the results, it is concluded that the capability of F. szowitsiana in reducing reactive oxygen species and the anti-inflammatory property of its methanolic extract may be due to its other ingredients.
https://ajp.mums.ac.ir/article_3040_a47ba978854f7300a83c2d014fe48782.pdf
2014-09-01
337
342
10.22038/ajp.2014.3040
Comet assay
DNA damage
Galbanic acid
Ferula szowitsiana
Kobra
Shirani
shiranik911@mums.ac.ir
1
Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
AUTHOR
Javad
Behravan
behravanj@mums.ac.ir
2
Biotechnology Research Center and Pharmacy School, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
AUTHOR
Fatemeh
Mosaffa
mosaffaf@mums.ac.ir
3
Biotechnology Research Center and Pharmacy School, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
AUTHOR
Mehrdad
Iranshahi
iranshahim@mums.ac.ir
4
Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mashhad University of Medical Sciences, I. R. Iran
AUTHOR
Babak
Mehmankhah
mehmankhahb@mums.ac.ir
5
Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
AUTHOR
Kamal
Razavi-Azarkhiavi
razavik901@mums.ac.ir
6
Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
AUTHOR
Gholamreza
Karimi
karimig@mums.ac.ir
7
Medical Toxicology Research Center and Pharmacy School, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
LEAD_AUTHOR
Biswas M, Haldar PK and Ghosh AK. 2010. Antioxidant and free-radical-scavenging effects of fruits of Dregea volubilis. J Nat Sci Biol Med, 1: 29-34.
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4
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Lee HJ, Jeong SJ, Lee HJ, Lee EO, Kim HS, Zhang Y, Ryu SY, Lee MH, Lü J, Kim SH. 2011. Galbanic acid isolated from Ferula assafoetida exerts in vivo anti-tumor activity in association with anti-angiogenesis and anti-proliferation .Pharm Res, 28: 597-609.
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Shahverdi AR, Fakhimi A, Zarrini G, Dehghan G and Iranshahi M. 2007. Galbanic acid from Ferula szowitsiana enhanced the antibacterial activity of penicillin G and cephalexin against Staphylococcus aureus. Biol Pharm Bull, 30: 1805-1807.
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22
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23
ORIGINAL_ARTICLE
Free radical scavenging capacity and antioxidant activity of methanolic and ethanolic extracts of plum (Prunus domestica L.) in both fresh and dried samples
Objectives: Consumption of fruits, such as plums and prunes, is useful in treating blood circulation disorder, measles, digestive disorder, and prevention of cancer, diabetes, and obesity. The paper presents a description of antioxidant and antiradical capacity of plum (Prunus domestica L.) in both fresh and dried samples. Materials and Methods: Samples were mixed with methanol and ethanol (as solvents) and were extracted on magnetic shaker, separately. The experiments were carried out to measure the Total Phenolic Content (TPC), Total Flavonoid Content (TFC), Total Antioxidant Capacity (TAC), Reducing Power Assay (RPA), Chain Breaking Activity (CBA), and quantity of Malondialdehyde (MDA), 2,2-Diphenyl-1-Picrylhydrazyl (DPPH),Nitric Oxide (NO),Hydrogen peroxide (H2O2) and superoxide(O2-) radicals inhibition. Results: The results showed that the highest values for the TPC, TFC,TAC, RPA, CBA, DPPH, and NO were related to ethanolic extractsof dried sample which showed statistically significant differences (p2O2 and O2-were related to ethanolic extracts of fresh sample. The correlations data were analyzed among all parameters and the TPC and TFC had a significant correlation (r2=0.977). Moreover, it was found that methanol was more successful in extraction procedure than ethanol (p<0.01). Conclusion: Findings suggest that the fresh samples are more successful in collecting oxygen free radicals such as superoxide (O2-) and peroxy radicals (ROO.) than dried.
https://ajp.mums.ac.ir/article_2827_6b24fc32620867466229f7ed2625529b.pdf
2014-09-01
343
353
10.22038/ajp.2014.2827
Antioxidant activity
correlation
Phenolic compounds
Prunusdomestica L
Amin
Morabbi Najafabad
amin_morabbi@yahoo.com
1
Department of Biology, Faculty of Science, Urmia University, Urmia, I. R. Iran
AUTHOR
Rashid
Jamei
r.jamei@urmia.ac.ir
2
Department of Biology, Faculty of Science, Urmia University, Urmia, I. R. Iran
LEAD_AUTHOR
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44
ORIGINAL_ARTICLE
Lipid-lowering activity of Cow urine ark in guinea pigs fed with a high cholesterol diet
Objectives: Cow urine ark (CUA), known as “Amrita” as mentioned in Ayurveda, contains anti-hyperglycemic and antioxidant effects. Therefore, we designed the present study to evaluate the lipid lowering activity of CUA and its possible implication in metabolic syndrome. Materials and Methods: Thirty guinea pigs of either sex were divided into five groups: Group 1 and 2 serving as a vehicle and sham control, received normal and high fat diet for 60 days respectively; Group 3, 4 and 5 received high fat diet for 60 days with CUA 0.8 ml/kg, 1.6 ml/kg and rosuvastatin (1.5 mg/kg) on thelast 30 days of study period, respectively. Serum lipid profile (total cholesterol, triglycerides, LDL-C, VLDL-C, HDL-C, total Cholesterol/HDL-C) and serum enzymes (ALT, AST, ALP, LDH and CK-MB) were performed in each group at the beginning and end of the study. Histological study of liver and kidney was done in each group. Results: CUA (0.8 ml/kg) significantly decreased the serum triglycerides and VLDL-C, but CUA (1.6 ml/kg) decreased the total serum Cholesterol, triglycerides and VLDL-C (p < 0.05). Higher dose (1.6 ml/kg) of CUA also increased HDL-C level, significantly (p < 0.05). CUA reduced serum AST, ALP and LDH level, which was statistically significant as well, while it also decreased the accumulation of lipid in hepatocytes as compared to sham control. Conclusions: CUA reduced triglycerides, increased HDL-C and found to be hepatoprotective in animals that are on a high fat diet.
https://ajp.mums.ac.ir/article_3036_5ea5e4f5477ef42adb14345f8571582e.pdf
2014-09-01
354
363
10.22038/ajp.2014.3036
Antioxidant activity
Cow urine ark
Dyslipidemia
Hypolipidemia
Guinea pig
Statin
Hiren Manubhai
Chawda
hiren_chawda1987@yahoo.co.in
1
Department of Pharmacology, Government Medical College, Bhavnagar-364001, Gujarat, India
AUTHOR
Divyesh Rasiklal
Mandavia
drdivyeshmandavia@gmail.com
2
Department of Pharmacology, Government Medical College, Bhavnagar-364001, Gujarat, India
AUTHOR
Seema Natvarlal
Baxi
seemabaxi@gmail.com
3
Department of Pathology, Government Medical College, Bhavnagar-364001, Gujarat, India
AUTHOR
Vishalkumar Kishorbhai
Vadgama
dr.vishalvadgama@gmail.com
4
Department of Pharmacology, Government Medical College, Bhavnagar-364001, Gujarat, India
AUTHOR
Chandrabhanu Rajkishor
Tripathi
cbrtripathi@yahoo.co.in
5
Department of Pharmacology, Government Medical College, Bhavnagar-364001, Gujarat, India
LEAD_AUTHOR
Achliya GS, Kotagale NR, Wadodkar SG, Dorle AK. 2003. Hepatoprotective activity of panchagavyaghrita against carbon tetrachloride induced hepatotoxicity in rats. Indian J Pharmacol, 35: 308-311.
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31
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35
ORIGINAL_ARTICLE
Ethnobotanical studies on plant resources of Mangowal, District Gujrat, Punjab, Pakistan
Abstract Objective: This study was conducted to collect indigenous traditional knowledge about the medicinal plants and their uses in Mangowal, District Gujrat, Punjab, Pakistan. Materials and Methods: The ethnomedicinal data were gathered through questionnaires and extensive personal dialogues with native individuals comprising 40 males and 20 females of diverse age groups between 50 to 80 years and also tabibs and hakims. Ethnobotanical investigations were directed from January 2013 to March 2013 under the acquiescence of university of Gujrat (UOG), Punjab, Pakistan. Results: About 40 plant species belonging to 22 families were investigated which are utilized by native people to cure various disorders and ailments such as asthma, ulcer, gonorrhea, piles, stomach pain, and skin diseases. Medicinal plants comprises of combination of active compounds which are side effect neutralizing and synergistic. Herbal medicines were prepared from different part of plants. Mostly used plant parts were leaves, fruits, barks, roots, seeds, and sometimes whole plant. Conclusion: The results demonstrated that the area is rich in vegetation but remained botanically virgin and not explored extensively and intensively.
https://ajp.mums.ac.ir/article_2158_3327bfa3a6be5b323591a621a5bffc2a.pdf
2014-09-01
364
370
10.22038/ajp.2014.2158
Ethnomedicinal surveys
Mangowal
Medicinal uses
Pakistan
Punjab
UOG
Muhammad
Parvaiz
parvaiz.botanist@gmail.com
1
Department of Botany, Institute of Chemical and Biological Sciences (ICBS), University of Gujrat (UOG), Hafiz Hayat Campus (HHC), Gujrat 50700, Punjab, Pakistan
AUTHOR
Amiri MS, Joharchi MR. 2013. Ethnobotanical investigation of traditional medicinal plants commercialized in the markets of Mashhad, Iran. Avicenna J Phytomed, 3: 254-271.
1
Hussain K., Nisar MF, Majeed A, Nawaz K, Bhatti KH. 2010. Ethnomedicinal survey for important plants of Jalalpur Jattan, District Gujrat, Punjab, Pakistan. Eth Leaflets, 14: 807-25.
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Khan J, Khan R, Qureshi RA. 2013. Ethnobotanical Study of Commonly Used Weeds of District Bannu, Khyber Pakhtunkhwa (Pakistan). J Med Plants Stud, 1: 6.
3
Khan MA, Khan MA, Mujtaba G, Hussain M. 2012. Ethnobotanical study about medicinal plants of Poonch valley Azad Kashmir. J animal plant Sci, 22: 493-500.
4
Mahmood A, Aqeel M, Hamayun S, Rizwana AQ, Yasmin S, Syed AG. 2011. Ethno medicinal survey of plants from district Bhimber Azad Jammu and Kashmir, Pakistan. J Med Plants Res, 5: 2348-2360.
5
Mahmood A, Mahmood A, Mujtaba G, Mumtaz MS, Kayani WK, Khan MA. 2012. Indigenous medicinal knowledge of common plants from district Kotli Azad Jammu and Kashmir Pakistan. J Med Plant Res, 6: 4961-4967.
6
Mahmood A, Riffat NM, Zabta KS, Aqeel M. 2011. Ethnobotanical survey of plants from Neelum, Azad Jammu and Kashmir, Pakistan. Pak J Bot, 43: 105-110.
7
Nasir E, Ali SI. 1971-1995. Flora of Pakistan. Fakhri printing press Karachi.
8
Qureshi RA, Ghufran MA, Gilani SA, Sultana K, Ashraf M. 2007. Ethnobotanical studies of selected medicinal plants of sudhan gali and ganga chotti hills, district bagh, azad kashmir. Pak J Bot, 39: 2275-2283.
9
Qureshi RM, Maqsood M, Arshad, Chaudhry AK. 2011. Ethnomedicinal uses of plants by the people of Kadhi areas of Khushab, Punjab, Pakistan. Pak J Bot, 43: 121-133.
10
Rahman AHMM. 2013. An ethnobotanical investigation on Asteraceae family at Rajshahi, Bangladesh. J Busin Administr Manag Sci Res, 2: 133-141.
11
Shah A, Marwat SK., Gohar F, Khan A, Bhatti KH, Amin M, Din NU, Ahmad M, Zafar M. 2013. Ethnobotanical study of medicinal plants of semi-tribal area of Makerwal and GullaKhel (Lying between Khyber Pakhtunkhwa and Punjab Provinces), Pakistan. Am J plant Sci, 4: 98-116.
12