%0 Journal Article %T Effect of linalool on the acquisition and reinstatement of morphine-induced conditioned place preference in mice %J Avicenna Journal of Phytomedicine %I Mashhad University of Medical Sciences %Z 2228-7930 %A Pourtaqi, Narjes %A Imenshahidi, Mohsen %A Razavi, Bibi Marjan %A Hosseinzadeh, Hossein %D 2017 %\ 05/01/2017 %V 7 %N 3 %P 242-249 %! Effect of linalool on the acquisition and reinstatement of morphine-induced conditioned place preference in mice %K Conditioned place preference (CPP) %K Linalool %K Memantine %K Mice %K Morphine %R 10.22038/ajp.2016.15567.1615 %X Objective: The effect of linalool, a terpene alcohol found in many plants, which inhibits NMDA receptors, on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) was evaluated in mice.Material and Methods: The effects of different doses of linalool (12.5, 25 and 50 mg/kg, i.p.), memantine (20 mg/kg, an NMDA receptor antagonist) and saline, in CPP induced by 40 mg/kg of morphine were investigated in mice. In another experiment, a single injection of morphine (10 mg/kg) reinstated the place reference following extinction of a place preference induced by morphine (40 mg/kg). Linalool (12.5, 25 and 50 mg/kg, i.p.), memantine (20 mg/kg) and saline were administrated 30 min before this priming dose of morphine.Results: In the first experiment, linalool (12.5 and 50 mg/kg) was able to decrease morphine-induced CPP. In the second part, linalool (25 and 50 mg/kg) reduced morphine-induced reinstatement of place preference. Both acquisition and reinstatement of morphine-induced CPP, were considerably decreased by memantine.Conclusion: The present study showed that linalool is able to reduce the acquisition and reinstatement of morphine-induced CPP which might be due tothrough NMDA receptors blocking. %U https://ajp.mums.ac.ir/article_8170_42827344d5db9b5b5e30530ff3fd41a7.pdf