%0 Journal Article %T Effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference in mice %J Avicenna Journal of Phytomedicine %I Mashhad University of Medical Sciences %Z 2228-7930 %A Hosseinzadeh, Hossein %A Imenshahidi, Mohsen %A Arasteh, Alireza %D 2011 %\ 12/01/2011 %V 2 %N 1 %P 24-30 %! Effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference in mice %K Aqueous saffron extract %K Crocus sativus L %K CPP (conditioned place preference) %K Morphine %K Mice %R 10.22038/ajp.2011.25 %X Objective: In the present study, the effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) in mice were investigated. Materials and Methods: Subcutaneous administration of morphine (40 mg/kg for four days) produced place preference. Intraperitoneal administration of aqueous extract (40 and 80 mg/kg for four days) 30 min before the morphine administration decreased the acquisition of morphine CPP. In other groups of animal, following extinction of a place preference induced by morphine (40 mg/kg), single administration of morphine (10 mg/kg) reinstated the place reference. The aqueous extract (80 mg/kg) 30 min before this priming dose of morphine blocked morphine-induced reinstatement of place preference. Results: These results show that aqueous saffron extract can reduce the acquisition and reinstatement of morphine-induced conditioned place preference. %U https://ajp.mums.ac.ir/article_25_5b54fdffe88748310af6ed44f248c8b2.pdf