%0 Journal Article %T Semen quality, hormone profile and histological changes in male albino rats treated with Corchorus olitorius leaf extract %J Avicenna Journal of Phytomedicine %I Mashhad University of Medical Sciences %Z 2228-7930 %A Orieke, Daniel %A Ohaeri, Obioma Christopher %A Ijeh, Ifeoma %A Nnah, Ijioma Solomon %D 2019 %\ 11/01/2019 %V 9 %N 6 %P 551-562 %! Semen quality, hormone profile and histological changes in male albino rats treated with Corchorus olitorius leaf extract %K Corchorus olitorius %K Anti-fertility %K Hormonal %K Sperm sample %K Histology %R 10.22038/ajp.2019.13426 %X Objective: In this study, the anti-fertility effect of Corchorus olitorius leaf extract (COLE) was evaluated in adult male rats. Materials and Methods: Forty rats assigned to 4 groups of 10 rats each, were orally given COLE for 28 days. Group 1 was the control group but groups 2, 3 and 4 were administered with 250, 500 and 1000 mg/kg body weight, respectively and were considered the test groups. Blood collection from the animals was performed at the end of treatments and blood samples were used for reproductive hormone assays. Also, sperm sample quality was ascertained, and basic organs were evaluated histologically for all groups. Results: A significant fall in relative organ weights for the testes and prostate was observed following high-dose treatment (p<0.05). Sperm sample pH, and individual sperm motility, viability, progressiveness and concentration decreased, while total abnormalities increased following high-dose (1000 mg/kg) treatment (p<0.05). Serum concentration of FSH significantly increased at 500 and 1000 mg/kg dose levels while LH and testosterone concentrations were significantly higher than control at all dose levels (p<0.05) except estrogen which was higher than control at 250 and 500 mg/kg but lower at 1000 mg/kg dose level. Control testes showed intact histological architecture with mature spermatid density of 300 cells per tubule and well differentiated Leydig cells, while those animals treated with 250 and 500 mg/kg of the extract, were without significant pathology but had average spermatid densities of 200 and 280 cells per tubule, respectively. Significant azoospermia and spermatid density of only 30 cells per tubule and prostatic degeneration were seen in the group treated with 1000 mg/kg body weight of the extract. Conclusion: Consumption of high amounts of C. olitorius may inhibit reproductive functions in males. %U https://ajp.mums.ac.ir/article_13426_963a604358faeaa7b1c1bb19a90d94ec.pdf