@article { author = {Khodadadi, Hadi and Pakdel, Roghayeh and Khazaei, Majid and Niazmand, Saeed and Bavarsad, Kowsar and Hajzadeh, Mousa-al-reza}, title = {A comparison of the effects of Portulaca oleracea seeds hydro-alcoholic extract and Vitamin C on biochemical, hemodynamic and functional parameters in cardiac tissue of rats with subclinical hyperthyroidism}, journal = {Avicenna Journal of Phytomedicine}, volume = {8}, number = {2}, pages = {161-169}, year = {2018}, publisher = {Mashhad University of Medical Sciences}, issn = {2228-7930}, eissn = {2228-7949}, doi = {10.22038/ajp.2017.21556.1812}, abstract = {Objective: The present study was performed to evaluate the effects of hydro-alcoholic extract of Portulaca oleracea (P. oleracea) seeds and Vitamin C on biochemical and hemodynamic parameters in cardiac tissue of rats with subclinical hyperthyroidism. Materials and Methods: Forty eight male rats were divided into six groups of 8 and treated for 4 weeks. T4 group received daily injection of levothyroxine sodium (20 μg/kg) and control group was given daily injection of saline. T4-Po groups were given T4 plus 100, 200, and 400 mg/kg of P. oleracea seeds extract in drinking water daily. T4-Vit C group received T4 plus daily injection of Vitamin C (100 mg/kg). At the end of the experiment, body weight, serum free T4 level, left ventricular developed pressure (LVDP), malondialdehyde (MDA) and total thiol levels were measured. Results: Free T4 levels were increased in all groups that were treated with T4. Weight gain was decreased in T4 and T4-Po100 groups compared to control group (p Conclusion: The results showed that P. oleracea extract has a protective effect on cardiac dysfunction due to subclinical hyperthyroidism induced by levothyroxine sodium in rats.}, keywords = {Portulaca oleracea seeds,Vitamin C,Heart,Subclinical hyperthyroidism,Rat}, url = {https://ajp.mums.ac.ir/article_9965.html}, eprint = {https://ajp.mums.ac.ir/article_9965_492b546fa2352e5bea0f9851c4699e87.pdf} }