@article { author = {Kahkeshani, Niloofar and Gharedaghi, Milad and Hadjiakhoondi, Abbas and Sharifzadeh, Mohammad and Khanavi, Mahnaz}, title = {Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts}, journal = {Avicenna Journal of Phytomedicine}, volume = {7}, number = {1}, pages = {73-79}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2228-7930}, eissn = {2228-7949}, doi = {10.22038/ajp.2016.7073}, abstract = {Objective: The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. Marrubium astracanicum Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various extracts of aerial parts of M. astracanicum.Materials and Methods: Antinociceptive activities of total hydroalcoholic extract (THE) and its n-hexane (non-polar) and residual partition (polar) fractions were analyzed using formalin test in mice. Morphine (5 mg/kg) and normal saline were used as positive and negative controls, respectively.Results: Intraperitoneal administration of THE (50, 100 and 200 mg/kg), non-polar fraction (200 mg/kg) and polar fraction (100 and 200 mg/kg), 30 min before formalin injection, caused significant analgesic activity in acute phase (0-5 min after formalin injection) of formalin test (p0.05 in comparison with morphine).  In chronic phase (15–60 min after formalin injection), non-polar and polar fractions (50, 100 and 200 mg/kg) showed significant analgesic activity (p0.05 in comparison with morphine).Conclusion: Different extracts of M. astracanicum demonstrated antinociceptive activity that support the traditional usage of Marrubium genus for the treatment of arthritis, gout and other inflammatory diseases.}, keywords = {Marrubium astracanicum,Pain measurment,Analgesic}, url = {https://ajp.mums.ac.ir/article_7073.html}, eprint = {https://ajp.mums.ac.ir/article_7073_99ed75e0ba13f29aed48fadd9603f491.pdf} }