@article { author = {Hajhashemi, Valiollah and Dashti, Gholamreza and Saberi, Salabali and Malekjamshidi, Parvin}, title = {The effect of hydroalcoholic extract and essential oil of Heracleum persicum on lipid profile in cholesterol-fed rabbits}, journal = {Avicenna Journal of Phytomedicine}, volume = {4}, number = {3}, pages = {144-150}, year = {2014}, publisher = {Mashhad University of Medical Sciences}, issn = {2228-7930}, eissn = {2228-7949}, doi = {10.22038/ajp.2014.2274}, abstract = {Objective: This study was designed to investigate the effect of hydroalcoholic extract and essential oil of Heracleum persicum (Apiaceae) on lipid profile of male hyperlipidemic rabbits. Materials and Methods: Thirty rabbits were randomly divided into six groups of five each. One group received normal diet and the other groups fed with a high cholesterol (2% W/W) diet for 7 weeks. Vehicle, hydroalcoholic extract (500 and 1000 mg/kg), essential oil (200 ml/kg), and lovastatin (5 mg/kg) were administered orally to animals and their effects on lipid profile were evaluated. Results: Essential oil of H. perscum significantly (p<0.05) lowered serum triglyceride level and increased HDL-cholesterol concentration. Moreover, hydroalcoholic extract (1000 mg/kg), essential oil (200 ml/kg), and lovastatin significantly (p<0.01) reduced serum concentration of total cholesterol and LDL-cholesterol. Conclusion: These findings suggest that essential oil of the plant fruits may have some benefits in reducing cardiovascular risk factors.}, keywords = {Essential oil,Heracleum persicum,Hyperlipidemia}, url = {https://ajp.mums.ac.ir/article_2274.html}, eprint = {https://ajp.mums.ac.ir/article_2274_0f4392f00f9c758950e8c4fd44d0fa9e.pdf} }