@article { author = {Emadi, Elnaz and Pouramir, Mahdi and Ghasemi-Kasman, Maryam and Feizi, Farideh and Halalkhor, Sohrab and Moghadamnia, Ali Akbar}, title = {Arbutin attenuates nephrotoxicity induced by gentamicin}, journal = {Avicenna Journal of Phytomedicine}, volume = {11}, number = {3}, pages = {210-217}, year = {2021}, publisher = {Mashhad University of Medical Sciences}, issn = {2228-7930}, eissn = {2228-7949}, doi = {10.22038/ajp.2020.16776}, abstract = {Objective: In this study, the impact of arbutin was examined in a gentamicin (GM)-induced nephrotoxicity model.Materials and Methods: Forty adult male Wistar rats were randomly assigned to five groups including control group; GM group, and three groups of GM+arbutin (25, 50 and 75 mg/kg). One day after the last injection of GM, creatinine, urea, carbonyl, thiobarbituric acid-reacting substance (TBARs), ferric reducing antioxidant power (FRAP) and 8-hydroxyguanosine levels were assessed in serum samples. Left and right kidneys were used for biochemical assays and histological evaluation, respectively.Results: Our data showed that the FRAP level (p<0.05), urea (p<0.001), creatinine (p<0.001), and 8-hydroxyguanosine (p<0.001) levels of serum samples, were increased in GM-treated rats compared to the controls. The serum levels of TBARS (p<0.001) and carbonyl increased in serum and renal tissue (p<0.001) of GM-treated animals. Conversely, arbutin attenuated serum creatinine, urea and 8-hydroxyguanosine, and TBARS (p<0.001). Administration of arbutin significantly decreased carbonyl levels in serum and renal tissue samples (p<0.001). Furthermore, the levels of FRAP increased in the serum (p<0.01) and renal tissue samples (p<0.001) of arbutin-treated animals. Histological staining showed that arbutin significantly inhibits kidney damages.Conclusion: Our data suggest that arbutin attenuates GM-induced nephrotoxicity through its free radicals-scavenging activity.}, keywords = {Gentamicin,Nephrotoxicity,Arbutin,Antioxidant,Histopathology}, url = {https://ajp.mums.ac.ir/article_16776.html}, eprint = {https://ajp.mums.ac.ir/article_16776_5070343cae4a1ed471f0578c499c2418.pdf} }