@article { author = {Columba-Palomares, María C. and Montiel-Ruiz, Rosa Mariana and Corona Sánchez, Lucia and Palafox-Gante, Daniel and Rodríguez-López, Verónica}, title = {Anti-inflammatory, antioxidant and antinociceptive activities of Russelia coccinea (L.) Wettst.}, journal = {Avicenna Journal of Phytomedicine}, volume = {11}, number = {2}, pages = {101-108}, year = {2021}, publisher = {Mashhad University of Medical Sciences}, issn = {2228-7930}, eissn = {2228-7949}, doi = {10.22038/ajp.2020.16718}, abstract = {Objective: Some species of the Russelia genus have been used  different illnesses associated with pain and inflammation. The aim of this work was to characterize the biological activities (anti-inflammatory and analgesic) and antioxidant capacity of methanol and dichloromethane extracts of Russelia coccinea.Materials and Methods: In this study, topical anti-inflammatory activity was tested in an in vivo model of 12-O-tetradecanoylphorbol acetate (TPA) induced mouse ear edema of organic extracts (doses: 0.03, 0.1, and 0.3 mg/ear). The antinociceptive activity was assessed using the formalin test in mice of organic extracts (doses: 56, 100 and 300 mg/kg ). Moreover, the antioxidant capacity of the extracts was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis(3-ethylbenzothiaziline-6-sulfonate) (ABTS) and ferric reducing antioxidant power (FRAP) assays.Results: Methanol (RcM) and dichloromethane (RcD) extracts of the R. coccinea aerial parts were found to inhibit ear edema (48.95 and 40.13%, respectively) at a dose of 0.3 mg/ear. Acute treatment with RcM produced a significant antinociceptive effect in the late phase of formalin-induced nociception. Moreover, RcM at doses of 56, 100 and 300 mg/kg showed a significant antinociceptive effect through the early and late phases in the formalin test. RcM and RcD showed weak antioxidant capacities in the ABTS and DPPH assays; however, when their reducing capacity was evaluated by the FRAP assay, RcM showed a reducing activity similar to Camellia sinensis standard at the proven concentration of 1000 μg/ml.Conclusion: According to the experimental findings, the organic extracts of R. coccinea display remarkable antinociceptive and anti-inflammatory activities.}, keywords = {Russelia coccinea,Plantaginaceae,Anti-inflammatory activity,Antinociceptive activity,Organic extracts,Antioxidant}, url = {https://ajp.mums.ac.ir/article_16718.html}, eprint = {https://ajp.mums.ac.ir/article_16718_db893852756eb6b99ecd9f2b2d316b4e.pdf} }