TY - JOUR ID - 14575 TI - Grape seed extract alleviates radiation-induced damages in human blood lymphocytes JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Ghasemnezhad Targhi, Reza AU - Saba, Valiallah AD - Department of Radiology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Radiology, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran Y1 - 2020 PY - 2020 VL - 10 IS - 4 SP - 398 EP - 406 KW - grape seed extract KW - Ionizing radiation KW - Micronucleus KW - Lymphocyte and Radioprotective Agents DO - 10.22038/ajp.2020.14575 N2 - Objective: Ionizing radiation induces deleterious effects in the biological systems by producing free radicals. Grape Seed Extract (GSE) as a free radical scavenger could protect the body against the damages. Materials and Methods: In this study, 12 healthy male volunteers were divided into Groups 1, 2, 3 and 4 and received 100, 300, 600 and 1000 mg GSE, respectively. Peripheral blood samples were collected from each volunteer 15 min before, and 1, 2, and 5 hr after GSE oral administration. Blood samples were then irradiated with 150 cGy of 100 kvp X-ray (Irradiated control group, was treated with only 1.5 Gy of X-rays). Cytogenic damages were detected by micronucleus assay. Results: Results showed that irradiation significantly increased the incidence of micronuclei (p Conclusion: Consumption of GSE before undergoing radiation protects human lymphocytes against X-rays by reducing radiation-induced genotoxicity. UR - https://ajp.mums.ac.ir/article_14575.html L1 - https://ajp.mums.ac.ir/article_14575_ed316c580e17fb1bb6365dde0d121d34.pdf ER -