TY - JOUR ID - 13899 TI - Cinnamon extract supplementation improves inflammation and oxidative stress induced by acrylamide: An experimental animal study JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Haidari, Fatemeh AU - Mohammadshahi, Majid AU - Abiri, Behnaz AU - Zarei, Mehdi AU - Fathi, Mojdeh AD - Nutrition and Metabolic Diseases Research Center, Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. AD - Hyperlipidemia Research Center, Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. AD - Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. AD - Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Y1 - 2020 PY - 2020 VL - 10 IS - 3 SP - 243 EP - 252 KW - Cinnamon extract KW - Acrylamide KW - Oxidative stress KW - Liver Enzyme KW - Inflammation DO - 10.22038/ajp.2019.13899 N2 - Objective: Toxic effects of acrylamide on body organs incline researches to prevent or decrease these effects. The objective of the present study was to evaluate the effects of cinnamon extract (CE) supplementation on inflammation and oxidative stress induced by acrylamide in rats. Materials and Methods: Thirty two rats were divided into four groups as follow 1) The control group received distilled water, 2) Acrylamide- intoxicated group was administrated with 35 ml/kg/day acrylamide for two weeks, 3) Acrylamide- intoxicated rats treated with CE 250 mg/kg/day for 28 days, and 4) Acrylamide- intoxicated rats treated with CE 500 mg/kg day for 28 days. Fasting blood sample was obtained for subsequent analysis. Results: The results showed that acrylamide- intoxicated group had significantly higher levels of malondialdehyde, tumor necrosis factor alpha, high sensitive C reactive protein, leptin and alanine transaminase (p0.05). Conclusion: This study suggests that cinnamon extract may potentially be effective as a dietary source of bioactive compounds for managing acrylamide intoxication. UR - https://ajp.mums.ac.ir/article_13899.html L1 - https://ajp.mums.ac.ir/article_13899_880e554cd07e44bc660d92f12a6da180.pdf ER -