TY - JOUR ID - 8699 TI - Effects of ethanolic extract of Jasminum grandiflorum Linn. flowers on wound healing in diabetic Wistar albino rats JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Hirapara, Hiren AU - Ghori, Vishal AU - Anovadiya, Ashish AU - Baxi, Seema AU - Tripathi, Chandrabhanu AD - GMERS Medical College, Junagadh, Gujarat, India AD - Billev Pharma East , Ljubljana, Slovenia AD - Government Medical College, Bhavnagar, Gujarat, India Y1 - 2017 PY - 2017 VL - 7 IS - 5 SP - 401 EP - 408 KW - Jasminum grandiflorum Linn. flowers KW - Streptozotocin induced diabetes KW - Granulation tissue DO - 10.22038/ajp.2017.14406.1580 N2 - Objective: To evaluate wound healing activity of ethanolic extract of Jasminum grandiflorum Linn. (J. grandiflorum) flowers in diabetic rats. Materials and Methods: Streptozotocin-induced diabetic Wistar albino rats were divided into six groups (n=6).Three groups – diabetic control, positive control (that received Glibenclamide) and treatment (that received J. grandiflorum Linn. Flower extract) were operated for excision wounds (EW). These groups were evaluated for wound contraction and re-epithelization. The other three groups were operated for incision wounds (IW) and dead space wounds (DW). Incision and dead space wounds were produced in the same rats. IWs were analyzed for wound breaking strength and the granulation tissues from DWs were analyzed for dry weight, hydroxyproline content, and histology. Results: IWs and DWs showed significant improvement in wound breaking strength (265.8±10.4 vs 332.5±8.2; p<0.05), granulation tissue dry weight (26.1±0.6vs 40.4±0.3; p<0.01) and hydroxyproline content (19.3±0.5 vs 32.6±0.8; p<0.01) in treatment group as compared to control group. Neo-angiogenesis was also high in treatment group. Wound contraction was earlier (day 14) in treatment group compared to diabetic control (day 20). No significant improvement was seen in re-epithelization in treatment group. Conclusion: Ethanolic extract of J. grandiflorum Linn. flowers increases granulation tissue formation as well as neo-angiogenesis. It also enhances wound contraction; however, re-epithelization was not significantly affected. J. grandiflorum Linn. flowers could be potentially effective in promotion of diabetic wounds healing by increasing granulation tissue formation and enhancing wound contraction; however, further studies are required for its clinical application. . UR - https://ajp.mums.ac.ir/article_8699.html L1 - https://ajp.mums.ac.ir/article_8699_b995ea83ae2cc62557f48f8d0f8b2281.pdf ER -