TY - JOUR ID - 4667 TI - Effect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Hosseini, Azar AU - Mousavi, Seyed Hamed AU - Ghanbari, Anis AU - Homaei-Shandiz, Fatemeh AU - Raziee, Hamid-Reza AU - Pezeshki-Rad, Masoud AU - Mousavi, Seyed Hadi AD - Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Oncology, Omid Hospitsal, Mashhad, Iran. AD - Department of Oncology, Emam Reza Hospitsal, Mashhad, Iran. AD - Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Y1 - 2015 PY - 2015 VL - 5 IS - 5 SP - 434 EP - 440 KW - Saffron KW - Cancer KW - Liver Metastases DO - 10.22038/ajp.2015.4667 N2 - Objective: Cancer represents the second cause of mortality in the world. Saffron as a medicinal plant is known for its anti-cancer and anti-depressant properties. In this randomized double blind clinical trial, the effects of saffron on response to treatment in patients suffering from liver metastasis were evaluated. Materials and Methods: Thirteen patients suffering from liver metastases who referred to Ghaem and Imam Reza hospital, Mashhad, Iran were included in this study and then divided into two different groups. Both groups received chemotherapy regimen. Patients in group one were treated with saffron capsule (50 mg, twice daily) during chemotherapy periods whereas patients in group two received placebo. A sum of the longest diameter were calculated and compared for all lesions in IV contrast CT scan before and after the treatment. Results: from 13 patients included in this study, six patients quit and seven continued until the end. In saffron-treated group, two patients showed partial and complete response (50%) whereas in placebo group, no response was seen. Also, two deaths in placebo and one in saffron group occurred. Conclusion: This research suggests that saffron might be useful in patients suffering from liver metastasis. However, further investigations with larger sample size are required. UR - https://ajp.mums.ac.ir/article_4667.html L1 - https://ajp.mums.ac.ir/article_4667_a0fdf5b066a0beb302df9a0c5ea98136.pdf ER -