TY - JOUR ID - 11100 TI - Histomorphological effects of the oil extract of Sphenocentrum jollyanum seed on benign prostatic hyperplasia induced by exogenous testosterone and estradiol in adult Wistar rats JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Mbaka, Godwin AU - Ogbonnia, Steve AU - Sulaiman, Adeola AU - Osiagwu, Daniel AD - Department of Anatomy, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria AD - Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Idi-Araba, Lagos, Nigeria AD - Department of Anatomy, Olabisi Onabanjo University, Remo Campus, Ogun State, Nigeria AD - Department of Anatomic and Molecular Pathology, College of Medicine of the University of Lagos, Nigeria Y1 - 2019 PY - 2019 VL - 9 IS - 1 SP - 21 EP - 33 KW - Histomorphology KW - Sphenocentrum jollyanum seed KW - Phytotherapy KW - Benign prostatic hyperplasia KW - male rats DO - 10.22038/ajp.2018.24039.1882 N2 - benefits due to its very potent anti-inflammatory and antioxidant properties. Despite its widespread use, it has not been validated for use in the treatment of benign prostatic hyperplasia (BPH). This study was conducted to examine histomorphological effects of SJ seed on BPH that usually causes bladder outlet obstruction. Materials and Methods: There were a total of six groups of animals each comprising 5 adult male rats. Apart from group 1 (normal control), in the remaining five groups, BPH was induced. Group 2 (negative control) was sacrificed immediately after BPH induction; groups 3 and 4 received the extract at 300 and 600 mg/kg respectively by gavages for thirty days; group 5 received finasteride (0.1 mg/kg) for thirty days and group 6 received the extract (600 mg/kg) simultaneously with the steroid administration for thirty days. The animals’ were weighed before the experiment and subsequently every three days until the end of the study. Results: The extract caused marked decrease in prostate weight of rats with BPH with histo-morphology of the tissue showing degenerated stromal and epithelial cells with few epithelial involutions of glandular tissue. Prostate specific antigen (PSA) level as well as testosterone level significantly (p<0.05) decreased in the treated groups compared to negative control.  BPH animals treated with extract/finasteride exhibited remarkable increases in anti-oxidant enzymes level with concurrent decreases in peroxidative activity. Conclusion: SJ effectively ameliorated prostatic hyperplasia in BPH animals causing marked degenerative changes in prostate stromal and epithelial cells and also exhibited marked anti-oxidant effect. UR - https://ajp.mums.ac.ir/article_11100.html L1 - https://ajp.mums.ac.ir/article_11100_9561e8c3eec6e68e853d822ebfddba46.pdf ER -