%0 Journal Article %T Capparis spinosa L. aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice %J Avicenna Journal of Phytomedicine %I Mashhad University of Medical Sciences %Z 2228-7930 %A Eddouks, Mohamed %A Lemhadri, Ahmed %A Hebi, Morad %A Hidani, Ahmed EL %A Zeggwagh, Naoufel Ali %A EL Bouhali, Bachir %A Hajji, Lhoussaine %A Burcelin, Remy %D 2017 %\ 03/01/2017 %V 7 %N 2 %P 191-198 %! Capparis spinosa L. aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice %K Diabetes %K Streptozotocin %K Insulin sensitivity %K Mice %R 10.22038/ajp.2016.7761 %X Objective: As the aqueous extract of Capparis spinosa (CS) possess antidiabetic effect, he present study aims to reveal the possible  mechanism of action of CS in diabetic mice.Materials and Methods: Both single and repeated oral administrations of aqueous extract of CS were performed in multi-low dose streptozotocin-induced (MLDS) diabetic mice. Euglycemic hyperinsulinemic clamp was used in association with the endogenous glucose production (perfusion rate of 3-3H glucose) to evaluate the effect of CS aqueous extract on insulin sensitivity.Results: Our study showed that aqueous extract of CS possess a potent hypoglycaemic activity in MLDS diabetic mice. Furthermore, the analysis perfusion of 3-3H glucose demonstrated  the parallel decrease of basal endogenous glucose production (EGP) with the hypoglycaemic activity. EGP was lower in CS-Treated group when compared to the control group (p<0.001). The euglycemic hyperinsulinemic clamp technique demonstrated that CS treatment improves insulin sensitivity in peripheral tissues.Conclusion: We conclude that the antihyperglycemic effet CS is probably due to the inhibition of basal endogenous glucose production and the improvement of insulin sensitivity in MLDS diabetic mice. %U https://ajp.mums.ac.ir/article_7761_b203ca4b3cb6490d2d1155e2946bd6b4.pdf