@article { author = {Pourtaqi, Narjes and Imenshahidi, Mohsen and Razavi, Bibi Marjan and Hosseinzadeh, Hossein}, title = {Effect of linalool on the acquisition and reinstatement of morphine-induced conditioned place preference in mice}, journal = {Avicenna Journal of Phytomedicine}, volume = {7}, number = {3}, pages = {242-249}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2228-7930}, eissn = {2228-7949}, doi = {10.22038/ajp.2016.15567.1615}, abstract = {Objective: The effect of linalool, a terpene alcohol found in many plants, which inhibits NMDA receptors, on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) was evaluated in mice.Material and Methods: The effects of different doses of linalool (12.5, 25 and 50 mg/kg, i.p.), memantine (20 mg/kg, an NMDA receptor antagonist) and saline, in CPP induced by 40 mg/kg of morphine were investigated in mice. In another experiment, a single injection of morphine (10 mg/kg) reinstated the place reference following extinction of a place preference induced by morphine (40 mg/kg). Linalool (12.5, 25 and 50 mg/kg, i.p.), memantine (20 mg/kg) and saline were administrated 30 min before this priming dose of morphine.Results: In the first experiment, linalool (12.5 and 50 mg/kg) was able to decrease morphine-induced CPP. In the second part, linalool (25 and 50 mg/kg) reduced morphine-induced reinstatement of place preference. Both acquisition and reinstatement of morphine-induced CPP, were considerably decreased by memantine.Conclusion: The present study showed that linalool is able to reduce the acquisition and reinstatement of morphine-induced CPP which might be due tothrough NMDA receptors blocking.}, keywords = {Conditioned place preference (CPP),Linalool,Memantine,Mice,Morphine}, url = {https://ajp.mums.ac.ir/article_8170.html}, eprint = {https://ajp.mums.ac.ir/article_8170_42827344d5db9b5b5e30530ff3fd41a7.pdf} }