TY - JOUR ID - 12741 TI - Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Qadiri, Afsaneh AU - Mirzaei Bavil, Fariba AU - Hamidian, Gholamreza AU - Zavvari Oskuye, Zohreh AU - Ahmadi, Mahdi AU - Oghbaei, Hajar AU - Mehri, Keivan AU - Vatankhah, Amir Mansour AU - Keyhanmanesh, Rana AD - Department of physiology, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran. AD - Department of physiology, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, Iran AD - Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AD - Drug applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Y1 - 2019 PY - 2019 VL - 9 IS - 4 SP - 374 EP - 385 KW - Diabetes KW - Troxerutin KW - Testis KW - Apoposis KW - Stress oxidative KW - Rat DO - 10.22038/ajp.2019.12741 N2 - Objective: The glucose-reducing effects of troxerutin was previously proven. This study was conducted to evaluate troxerutin effect on testicular structure and spermatozoid parameters in type-1 diabetic adult male rats. Materials and Methods: Fifty male Wistar rats were randomly classified into 5 groups as follows: control (C), troxerutin (T), diabetic (DM), troxerutin-treated DM (DT) and insulin-treated DM (DI). Testicular structure, apoptosis, lipid peroxidation and antioxidant activity, and spermatozoid parameters were assessed 4 weeks after initiation of the interventions. Results: The results revealed that diabetes caused testicular stereological changes and significantly increased blood glucose level, testicular MDA content and apoptosis but decreased insulin level, testicular GPX activity, and sperm parameters compared to controls (p Conclusion: Taken together, troxerutin, comparable to insulin, effectively improved DM-induced testicular dysfunction and sperm parameters in diabetic rats and these effects might be mediated through troxerutin’s anti-apoptotic effects. UR - https://ajp.mums.ac.ir/article_12741.html L1 - https://ajp.mums.ac.ir/article_12741_42f5452102d9eef12a47ec3e38cece8a.pdf ER -