TY - JOUR ID - 10014 TI - The effect of Ficus carica latex on 7, 12-dimethylbenz (a) anthracene-induced breast cancer in rats JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Fatemi, Mahnoosh AU - Ghandehari, Fereshte AD - Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran AD - Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran Y1 - 2018 PY - 2018 VL - 8 IS - 4 SP - 286 EP - 295 KW - Breast Cancer KW - Ficus carica latex KW - hematological parameters KW - Histopathology KW - Rat DO - 10.22038/ajp.2017.10014 N2 - Objective: In traditional medicine, Ficus carica (also known as fig) latex is recognized as a remedy with various therapeutic effects. Recently, in vitro studies have reported the anticancer effect of this latex on cancer cell lines. This study evaluated the effect of this latex on breast cancer growth, hematological parameters, and histopathology in rats. Materials and Methods: Twenty-four female rats were randomly divided into 3 groups. In cancerous group, 0.5 ml 7, 12-dimethylbenz (a) anthracene was injected to nipple for breast cancer induction. The control group received sesame oil at the same volume through similar route. In fig latex treated group (Fle), breast cancer was induced and then 0.5 ml of fig latex was intratumorally injected on a daily basis for 4 weeks. Tumor size was measured at the 2nd, 4th and 6th weeks of the experiment. Blood samples were used for investigation of the hematological parameters and livers, kidneys and tumor tissues were removed for histopathological analysis. Results: The tumor size in Fle group was significantly decreased compared to the cancerous group. Haematocrit, hemoglobin, RBC and their indices were significantly decreased, whereas platelet, leukocyte and white blood cell numbers were significantly increased in cancerous group compared to the control group. There were no changes in these parameters in the Fle group compared to the control group. There were severe pathological changes in the livers and kidneys of cancerous group, but not in Fle group. Conclusion: These results suggest that fig latex could decrease tumor growth without having any adverse effect on hematological and histological factors. However, further investigation is required in this field. UR - https://ajp.mums.ac.ir/article_10014.html L1 - https://ajp.mums.ac.ir/article_10014_34cdd5cce770f8dafdcca2954484fec6.pdf ER -