%0 Journal Article %T Evaluation of the anti–depressant activity of Myristica fragrans (Nutmeg) in male rats %J Avicenna Journal of Phytomedicine %I Mashhad University of Medical Sciences %Z 2228-7930 %A Moinuddin, Ghulam %A Devi, Kshama %A Kumar Khajuria, Deepak %D 2012 %\ 03/01/2012 %V 2 %N 2 %P 72-78 %! Evaluation of the anti–depressant activity of Myristica fragrans (Nutmeg) in male rats %K Antidepressant activity %K Imipramine %K Myristica fragrans %R 10.22038/ajp.2012.33 %X Objective: The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans(MS). Materials and Methods: Male Wistar rats were subjected to imipramine and herbal extract ofMS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST). Results: Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST. Conclusion: Our study demonstrated the potential antidepressant activity of MS. %U https://ajp.mums.ac.ir/article_33_2b1e89476c706346ee7f1fe81c7408ef.pdf