@article { author = {Norouzi, Fatemeh and Abareshi, Azam and Anaeigoudari, Akbar and Shafei, Mohammad Naser and Gholamnezhad, Zahra and Saeedjalali, Mohsen and Mohebati, Reza and Hosseini, Mahmoud}, title = {The effects of Nigella sativa on sickness behavior induced by lipopolysaccharide in male Wistar rats}, journal = {Avicenna Journal of Phytomedicine}, volume = {6}, number = {1}, pages = {104-116}, year = {2016}, publisher = {Mashhad University of Medical Sciences}, issn = {2228-7930}, eissn = {2228-7949}, doi = {10.22038/ajp.2016.6205}, abstract = {Objective: Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. Materials and Methods: The rats were divided into five groups (n=10 in each): (1) control (saline), (2) LPS (1 mg/kg, administered two hours before behavioral tests), (3-5) LPS-Nigella sativa 100 , 200 and 400 mg/kg (LPS-NS 100, LPS-NS 200 and LPS-NS 400, respectively). Open- field (OF), elevated plus maze (EPM) and forced swimming test (FST) were performed. Results: In OF, LPS reduced the peripheral crossing, peripheral distance, total crossing and total distance compared to control (pConclusion: The results of the present study showed that the hydro-alcoholic extract of NS reduced the LPS-induced sickness behaviors in rats. Further investigations are required for better understanding the responsible compound (s) and the underlying mechanism(s).}, keywords = {Rat,Lipopolysaccharide,Nigella Sativa,Sickness behavior}, url = {https://ajp.mums.ac.ir/article_6205.html}, eprint = {https://ajp.mums.ac.ir/article_6205_ef004867d586346ccda0eb116b2165fd.pdf} }